COMSAE LATEST EXAM PREP QUESTIONS
AND ANSWERS PDF 2026
▶ SERM - Partial agonist at estrogen receptors in hypothalamus.
prevents normal feedback inhibition and increased release of LH and FSH
from pituitary = stimulates ovaries
Used to treat infertility and PCOS
may cause hot flashes, ovarian enlargement, multiple simultaneous
pregnancies and visual disturbances.. Answer: Clomiphene
▶ synthetic androgen that acts as partial agonist at androgen receptors
used clinically in endometriosis and hereditary angioedema.
toxicities include weight gain, edema, acne, hirsutism, masculinization,
decreased HDL levels, hepatotoxicity.. Answer: Danazol
▶ inhibits PDE-5 causing an increase in cGMP
smooth muscle relaxation in the corpus cavernosum, increase in blood flow
and penile erection
treatment of erectile dysfunction.
impaired blue - green color vision
Risk of life threatening hypotension in patients taking nitrates.. Answer:
Sildenafil, Vardenafil
▶ Binds estrogen receptors
Used clinically in hypogonadism or ovarian failure, menstrual abnormalities,
HRT in postmenopausal women
, use in men with androgen-dependent prostate cancer
contraindications - ER - positive breast cancer, history of DVT's. Answer:
Estrogens (Ethinyl Estradiol, DES, mestranol)
▶ decreases the production of leukotrines and prostaglandins by inhibiting
phospholipase A2 and expression of COX. Answer: Glucocorticoids
▶ used to stimulate labor, uterine contractions, milk let down
controls uterine hemorrhage.. Answer: Oxytocin
▶ inhibits neuronal high frequency firing by reducing the ability of SODIUM
channels to recover from inactivation (3). Answer: Phenytoin,
Carbamazapine and Valproic Acid
▶ AST:ALT ratio >2 signifies?. Answer: alcoholic hepatitis
▶ HLA-B8 is associated with. Answer: Graves disease
▶ HLA-B27 is associated with. Answer: ankylosing spondylitis
▶ HLA-A3 is associated with. Answer: hemochromatosis
▶ HLA-DR3 associated with?. Answer: DM type 1
▶ stimulates peristalsis by antagonizing D2 (dopamine) receptors, thereby
increasing resting tone, contractility LES tone, and overall motility
Used to treat Diabetic gastroparesis
SE - extrapyramidal symptoms. Answer: Metoclopramide
▶ antihistamine used for nausea and motion sickness
anticholinergic properties and can thus produce drowsiness and dry mouth.
Answer: Meclizine
▶ Polyostotic fibrous dysplasia. Answer: bone is replaced by fibroblasts,
collagen and irregular bony trabeculae.
AND ANSWERS PDF 2026
▶ SERM - Partial agonist at estrogen receptors in hypothalamus.
prevents normal feedback inhibition and increased release of LH and FSH
from pituitary = stimulates ovaries
Used to treat infertility and PCOS
may cause hot flashes, ovarian enlargement, multiple simultaneous
pregnancies and visual disturbances.. Answer: Clomiphene
▶ synthetic androgen that acts as partial agonist at androgen receptors
used clinically in endometriosis and hereditary angioedema.
toxicities include weight gain, edema, acne, hirsutism, masculinization,
decreased HDL levels, hepatotoxicity.. Answer: Danazol
▶ inhibits PDE-5 causing an increase in cGMP
smooth muscle relaxation in the corpus cavernosum, increase in blood flow
and penile erection
treatment of erectile dysfunction.
impaired blue - green color vision
Risk of life threatening hypotension in patients taking nitrates.. Answer:
Sildenafil, Vardenafil
▶ Binds estrogen receptors
Used clinically in hypogonadism or ovarian failure, menstrual abnormalities,
HRT in postmenopausal women
, use in men with androgen-dependent prostate cancer
contraindications - ER - positive breast cancer, history of DVT's. Answer:
Estrogens (Ethinyl Estradiol, DES, mestranol)
▶ decreases the production of leukotrines and prostaglandins by inhibiting
phospholipase A2 and expression of COX. Answer: Glucocorticoids
▶ used to stimulate labor, uterine contractions, milk let down
controls uterine hemorrhage.. Answer: Oxytocin
▶ inhibits neuronal high frequency firing by reducing the ability of SODIUM
channels to recover from inactivation (3). Answer: Phenytoin,
Carbamazapine and Valproic Acid
▶ AST:ALT ratio >2 signifies?. Answer: alcoholic hepatitis
▶ HLA-B8 is associated with. Answer: Graves disease
▶ HLA-B27 is associated with. Answer: ankylosing spondylitis
▶ HLA-A3 is associated with. Answer: hemochromatosis
▶ HLA-DR3 associated with?. Answer: DM type 1
▶ stimulates peristalsis by antagonizing D2 (dopamine) receptors, thereby
increasing resting tone, contractility LES tone, and overall motility
Used to treat Diabetic gastroparesis
SE - extrapyramidal symptoms. Answer: Metoclopramide
▶ antihistamine used for nausea and motion sickness
anticholinergic properties and can thus produce drowsiness and dry mouth.
Answer: Meclizine
▶ Polyostotic fibrous dysplasia. Answer: bone is replaced by fibroblasts,
collagen and irregular bony trabeculae.
