NR546 Midterm Exam Question and
Answer | Grade A+ | Trusted
Answers Pack
• Neuroscience matters -✓✓Neuroscience is the foundation for mental health
prescribing, especially as the future moves toward symptom-based prescribing
rather than selecting a drug class based on a diagnosis. Know what area of the
brain is associated with presenting symptoms AND how the medication works on
that area of the brain to treat that symptom (the medication mechanism of action)
• Functional neuroanatomy -✓✓Classifying how regions within the nervous system
relate to psychology and behavior.
If a particular area of the brain is affected, what is the expected response? What
symptoms would you expect to see? Link the assessment to the affected brain area.
• Ethical Issues -✓✓course Explore section and readings
• Epigenetics -✓✓the study of influences on gene expression that occur without a
DNA change
• Why is epigenetics important? -✓✓Involved in switching genes on and off
i.e. controlling transcription/translation
• How does epigenetics impact a person's mental health? -✓✓
• Genetics -✓✓The scientific study of heredity
• How does the CYP450 affect pharmacodynamics and pharmacokinetics? -✓✓
• What are some very common/concerning interactions? -✓✓Also see Stahl Ch 2.
• Incidence of mental illness -✓✓what factors are increasing the incidence? This is
covered in the course Explore section
• CYP450 -✓✓-Enzyme family most important in metabolizing drugs
, -Always available in the liver
-Evolved to eliminate toxic chemicals from plants
-Function can be altered by alcohol & barbiturates
• CYP450 inducers -✓✓Kenytoin Rides Shotgun in Barbie's Crazy Girly Motor
Car
phenytoin
rifampin
st. john's wart
barbiturates
chronic alcohol use
griseofulvan
modafinil
carbamazepine
• How does an inhibitor or inducer affect medication efficacy? -✓✓
• CYP450 inhibitors -✓✓CRACK AMIGOS
Cimetidine
Ritonavir (protease inhibitor)
Amiodarone
Ciprofloxacin
Ketocanazole (and other azoles)
Acute alcohol use
Macrolides
Isoniazid
Grapefruit Juice
Omeprazole
Sulfonamides
• Carbamazepine (Tegretol) -✓✓INDUCER: anticonvulsant/mood stabilizer
• How does combining carbamazepine with another medication affect your
prescribing? -✓✓
• What happens if you prescribe an inducer or an inhibitor with a substrate? -✓✓
Answer | Grade A+ | Trusted
Answers Pack
• Neuroscience matters -✓✓Neuroscience is the foundation for mental health
prescribing, especially as the future moves toward symptom-based prescribing
rather than selecting a drug class based on a diagnosis. Know what area of the
brain is associated with presenting symptoms AND how the medication works on
that area of the brain to treat that symptom (the medication mechanism of action)
• Functional neuroanatomy -✓✓Classifying how regions within the nervous system
relate to psychology and behavior.
If a particular area of the brain is affected, what is the expected response? What
symptoms would you expect to see? Link the assessment to the affected brain area.
• Ethical Issues -✓✓course Explore section and readings
• Epigenetics -✓✓the study of influences on gene expression that occur without a
DNA change
• Why is epigenetics important? -✓✓Involved in switching genes on and off
i.e. controlling transcription/translation
• How does epigenetics impact a person's mental health? -✓✓
• Genetics -✓✓The scientific study of heredity
• How does the CYP450 affect pharmacodynamics and pharmacokinetics? -✓✓
• What are some very common/concerning interactions? -✓✓Also see Stahl Ch 2.
• Incidence of mental illness -✓✓what factors are increasing the incidence? This is
covered in the course Explore section
• CYP450 -✓✓-Enzyme family most important in metabolizing drugs
, -Always available in the liver
-Evolved to eliminate toxic chemicals from plants
-Function can be altered by alcohol & barbiturates
• CYP450 inducers -✓✓Kenytoin Rides Shotgun in Barbie's Crazy Girly Motor
Car
phenytoin
rifampin
st. john's wart
barbiturates
chronic alcohol use
griseofulvan
modafinil
carbamazepine
• How does an inhibitor or inducer affect medication efficacy? -✓✓
• CYP450 inhibitors -✓✓CRACK AMIGOS
Cimetidine
Ritonavir (protease inhibitor)
Amiodarone
Ciprofloxacin
Ketocanazole (and other azoles)
Acute alcohol use
Macrolides
Isoniazid
Grapefruit Juice
Omeprazole
Sulfonamides
• Carbamazepine (Tegretol) -✓✓INDUCER: anticonvulsant/mood stabilizer
• How does combining carbamazepine with another medication affect your
prescribing? -✓✓
• What happens if you prescribe an inducer or an inhibitor with a substrate? -✓✓
