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DR.LASITH RANASINGHE
Review cardiovascular physiology, including cardiac output, vascular
control, blood pressure regulation, and hemodynamics’. (179 cards)
1
Q
List three adaptations that maximize exchange at capillaries.
ANSWERS:
Low velocity (0.05-0.1 cm/s vs. 25 cm/s in the aorta)
Large surface area (6300 m²)
Thin walls
2
Q
List locations of fenestrated capillaries.
ANSWERS:
Glomerulus
Endocrine glands (e.g., thyroid, pituitary)
3
,Q
Where are discontinuous capillaries found?
ANSWERS:
In liver sinusoids.
4
Q
Which factors cause precapillary sphincters to dilate, allowing blood
flow through the capillary bed?
ANSWERS:
Nitric oxide
Decreased PO₂ or increased PCO₂
Elevated temperature
Rising K⁺
Acidosis (e.g., lactate)
Prostacyclin, thromboxane, and endothelins
5
Q
What colloid oncotic pressure is exerted by albumin in the
intravascular space?
ANSWERS:
26 mm Hg
NOTE: interstitial oncotic pressure is around 17 mm Hg
6
,Q
State the Starling equation for capillary fluid dynamics.
ANSWERS:
Q = Kf (Pc−Pi)−σ(πc−πi)
Where:
Q → net fluid movement
Kf (K) → filtration coefficient (permeability × surface area)
Pc / Pi → capillary & interstitial hydrostatic pressures
πc / πi → capillary & interstitial oncotic pressures
σ (s) → reflection coefficient (protein leakiness)
7
Q
What does the reflection coefficient for albumin indicate?
ANSWERS:
It indicates how much a membrane restricts the passage of albumin
across it.
8
Q
What are the rough capillary hydrostatic pressures at the arteriolar
and venous ends of a capillary?
ANSWERS:
Arteriolar: 32 mm Hg
Venous: 15 mm Hg
, NOTE: interstitial hydrostatic pressure ranges from - 2 mm Hg in the
subcutaneous tissue to +6 mm Hg in the brain.
9
Q
How much fluid is returned to the circulation by the lymphatics every
day?
ANSWERS:
2-4 L/day
NOTE: 20 L/day of fluid leaves the capillaries but about 18 L will be
reabsorbed into the capillaries (due to oncotic pressure).
10
Q
List some factors that increase capillary permeability.
ANSWERS:
Substance P
Histamine
IL1, IL4 and IL6 (in inflammatory responses)
Kinins (e.g. bradykinin)
Accumulation of osmotically active substances in interstitial
space
Burns
Acute lung injury
Reperfusion injury
11