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Review renal, hepatic, and gastrointestinal physiology to understand
metabolism, drug clearance, and perioperative fluid balance. (63
cards)
1
Q
What does pancreatic lipase do?
ANSWERS:
Converts triglycerides to free fatty acids and 2-monoglycerides with
the help of colipase.
2
Q
Which cells secrete gastric acid, gastrin, pepsinogen,
and somatostatin in the stomach?
ANSWERS:
Gastric Acid: Parietal cells
Gastrin: G-cells
Pepsinogen: Chief cells
Somatostatin: D-cells
,3
Q
How much of the hepatic oxygen requirement and blood flow is
supplied by the hepatic portal vein?
ANSWERS:
Hepatic portal vein supplies 75% of blood flow and 50% of oxygen.
The common hepatic artery is a branch of the coeliac trunk.
4
Q
Describe the hepatic artery buffer response mechanism.
ANSWERS:
Compensatory mechanism where the hepatic artery vasodilates
due to reduced portal venous flow.
Adenosine is secreted at a constant rate into the space of Mall.
Reduced portal flow leads to adenosine accumulation,
causing vasodilation of the hepatic artery.
5
Q
Which kidney cells respond to increased pCO₂ by upregulating acid
secretion?
ANSWERS:
Alpha intercalated cells in the collecting duct.
Most H⁺ removal in urine occurs via the H⁺/K⁺ antiporter in the distal
convoluted tubule.
, 6
Q
List the parts of a nephron and the diuretics that act on each.
ANSWERS:
PCT: carbonic anhydrase inhibitors
Ascending limb: osmotic and loop diuretics
Early DCT: thiazide diuretics
DCT: potassium-sparing diuretics
Late DCT and Collecting Duct: aldosterone antagonists