Primary FRCA Pharmacology: Analgesics & Muscle Relaxants Exam | Most Recent Exam Actual Complete Real Exam 160 Questions And Correct Answers (Verified Answers) Already Graded A+ |Guaranteed Success!! Newest Exam | Just Released!! Revi

Primary FRCA Pharmacology: Analgesics & Muscle
Relaxants Exam 2026-2027 | Most Recent Exam
Actual Complete Real Exam 160 Questions And
Correct Answers (Verified Answers) Already
Graded A+ |Guaranteed Success!! Newest Exam |
Just Released!!


Review opioids, NSAIDs, local anaesthetics, neuromuscular blockers, and
reversal drugs. (160 cards)
1
Q
What feature of fentanyl makes it unsuitable as a total intravenous anaesthetic?

ANSWERS:


Highly lipid soluble (600 times more than morphine), leading to accumulation in
tissues.
This results in a high context-sensitive half-time, making timely wake-up
impractical.
2
Q
What are the benefits of cisatracurium over atracurium?

ANSWERS:


 More potent
 Less histamine release
 Similar duration of action
ONLY degraded by Hofmann degradation.

,3
Q
State the pKa, relative lipid solubility, relative potency, and volume of
distribution of pethidine.

ANSWERS:


 pKa: 8.7
 Relative lipid solubility: 30x morphine
 Relative potency: 0.1x morphine
 Volume of distribution: 4 L/kg
 Protein binding: 60%
4
Q
Which muscle relaxants can be reversed by sugammadex?

ANSWERS:


Aminosteroids: rocuronium, vecuronium
5
Q
How does the train-of-four output relate to receptor occupancy by muscle
relaxants?

ANSWERS:


 All twitches present: < 70% occupancy
 1 twitch lost: 70%
 2 twitches lost: 80%
 3 twitches lost: 90%
 All twitches lost: 95-100%

,6
Q
Describe the inheritance pattern of suxamethonium apnoea.

ANSWERS:


Autosomal recessive mutation on chromosome 3.
7
Q
What mechanism causes opioid tolerance?

ANSWERS:


Uncoupling of opioid receptors from G-proteins leads to decreased receptor
sensitivity.
8
Q
What is the intramuscular dose of suxamethonium for laryngospasm?

ANSWERS:


4 mg/kg
9
Q
Which opioids are associated with reducing seizure threshold?

ANSWERS:


 Pethidine
 Tramadol
10
Q

, How is atracurium metabolised?

ANSWERS:


 60% ester hydrolysis by non-specific esterases
 40% Hofmann degradation (slows in acidosis and cold)
11
Q
What is the dose of atracurium?

ANSWERS:


0.5 mg/kg
12
Q
What dose of sugammadex should be used based on the depth of blockade?

ANSWERS:


 Immediate reversal after RSI: 16 mg/kg
 Deep block (1-2 twitches on post-tetanic count): 4 mg/kg
 Moderate block (2 twitches on ToF): 2 mg/kg
No dose alteration in renal impairment.
13
Q
What is the pKa of alfentanil?

ANSWERS:


6.5
14