Primary FRCA Pharmacology: Emergency & Miscellaneous
Drugs Exam 2026-2027 | Most Recent Exam Actual Complete
Real Exam 251 Questions And Correct Answers (Verified
Answers) Already Graded A+ |Guaranteed Success!! Newest
Exam | Just Released!!
Understand emergency drugs (adrenaline, atropine, amiodarone),
antiemetics, and other perioperative medications. (251 cards)
1
Q
What is the vasoconstrictive mechanism of action of methylene blue?
ANSWERS:
Inhibits nitric oxide induced cGMP activity resulting
in vasoconstriction.
2
Q
How does vancomycin work?
ANSWERS:
Glycopeptide antibiotic: Inhibit cell wall synthesis by binding to and
interfering with the ongoing synthesis of peptidoglycan cell wall.
3
Q
What is carboprost?
ANSWERS:
,Prostaglandin F2-alpha analogue used in management of PPH. It can
precipitate bronchospasm.
4
Q
What is the mechanism of action of nicorandil?
ANSWERS:
Potassium channel activator
Activation of ATP-sensitive potassium channels within the walls of
arterioles causes hyperpolarisation, which reduces intracellular
calcium. In turn, this leads to arteriolar vasodilation and subsequent
reduced blood pressure.
5
Q
Describe the pKa, protein binding and relative solubility of prilocaine.
ANSWERS:
pKa: 7.7
Protein Binding: 55%
Solubility: 50 times the solubility of procaine
6
Q
Which class of antibiotics exhibits concentration-dependent killing?
ANSWERS:
,Aminoglycosides
(the higher the concentration, the greater the bactericidal action)
Beta-lactams are time-dependent.
7
Q
What is the mechanism of action of aminoglycoside antibiotics?
ANSWERS:
Prevent protein synthesis by binding to the 30S ribosomal subunit
8
Q
Which classes of antibiotics work by inhibiting bacterial protein
synthesis?
ANSWERS:
50S: macrolides, clindamycin, chloramphenicol
30S: aminoglycosides, tetracycline
9
Q
Which intravenous antiviral agent causes obstructive crystal
nephropathy?
ANSWERS:
Aciclovir
10
Q
, What is a structural isomer of dobutamine used in anaesthetics?
ANSWERS:
Dihydrocodeine
11
Q
What dose of intralipid should be used in local anaesthetic toxicity?
ANSWERS:
1: Bolus Dose at 1.5 ml/kg over 1 min
2: Infusion at 15 mL/kg/hour
3: Second Bolus + Increase Infusion to 30 mL/kg/hour (if
cardiovascular instability not sorted)
12
Q
List the absolute contraindications for parecoxib.
ANSWERS:
History of ischaemic heart disease
Active GI bleeding
Active GI ulceration
Cerebrovascular disease
CABG
IBD
Heart failure
Peripheral vascular disease
Drugs Exam 2026-2027 | Most Recent Exam Actual Complete
Real Exam 251 Questions And Correct Answers (Verified
Answers) Already Graded A+ |Guaranteed Success!! Newest
Exam | Just Released!!
Understand emergency drugs (adrenaline, atropine, amiodarone),
antiemetics, and other perioperative medications. (251 cards)
1
Q
What is the vasoconstrictive mechanism of action of methylene blue?
ANSWERS:
Inhibits nitric oxide induced cGMP activity resulting
in vasoconstriction.
2
Q
How does vancomycin work?
ANSWERS:
Glycopeptide antibiotic: Inhibit cell wall synthesis by binding to and
interfering with the ongoing synthesis of peptidoglycan cell wall.
3
Q
What is carboprost?
ANSWERS:
,Prostaglandin F2-alpha analogue used in management of PPH. It can
precipitate bronchospasm.
4
Q
What is the mechanism of action of nicorandil?
ANSWERS:
Potassium channel activator
Activation of ATP-sensitive potassium channels within the walls of
arterioles causes hyperpolarisation, which reduces intracellular
calcium. In turn, this leads to arteriolar vasodilation and subsequent
reduced blood pressure.
5
Q
Describe the pKa, protein binding and relative solubility of prilocaine.
ANSWERS:
pKa: 7.7
Protein Binding: 55%
Solubility: 50 times the solubility of procaine
6
Q
Which class of antibiotics exhibits concentration-dependent killing?
ANSWERS:
,Aminoglycosides
(the higher the concentration, the greater the bactericidal action)
Beta-lactams are time-dependent.
7
Q
What is the mechanism of action of aminoglycoside antibiotics?
ANSWERS:
Prevent protein synthesis by binding to the 30S ribosomal subunit
8
Q
Which classes of antibiotics work by inhibiting bacterial protein
synthesis?
ANSWERS:
50S: macrolides, clindamycin, chloramphenicol
30S: aminoglycosides, tetracycline
9
Q
Which intravenous antiviral agent causes obstructive crystal
nephropathy?
ANSWERS:
Aciclovir
10
Q
, What is a structural isomer of dobutamine used in anaesthetics?
ANSWERS:
Dihydrocodeine
11
Q
What dose of intralipid should be used in local anaesthetic toxicity?
ANSWERS:
1: Bolus Dose at 1.5 ml/kg over 1 min
2: Infusion at 15 mL/kg/hour
3: Second Bolus + Increase Infusion to 30 mL/kg/hour (if
cardiovascular instability not sorted)
12
Q
List the absolute contraindications for parecoxib.
ANSWERS:
History of ischaemic heart disease
Active GI bleeding
Active GI ulceration
Cerebrovascular disease
CABG
IBD
Heart failure
Peripheral vascular disease
