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Apply principles of physics and measurement to anaesthesia,
including pressure, flow, gas laws, vaporizers, electrical safety, and
monitoring. (232 cards)
1
Q
State the combined gas law.
ANSWERS:
PV = nRT
The product of pressure and volume is proportional to the absolute
temperature.
2
Q
Demonstrate the working going from the combined gas law to the
universal gas law.
ANSWERS:
PV/T = Constant (R)
Constant is proportional to the no. of moles of gas:
PV/T = nR
,Rearrange the equation to get universal gas equation:
PV = nRT
3
Q
What is the molar gas constant?
ANSWERS:
8.31 J/K/mol
4
Q
Define:
diffusion
ANSWERS:
Movement of a substance from an area of high concentration to an
area of lower concentration.
5
Q
What is the difference between diffusion and flow?
ANSWERS:
Flow is the bulk movement of fluid driven by pressure differences.
Diffusion is the passive, random movement of molecules resulting in
net transport from high to low concentration.
6
Q
,State Fick’s Law of Diffusion.
ANSWERS:
States that the rate of transfer of a gas through the membrane is:
Proportional to tissue area
Proportional to difference in gas partial pressure between two
sides
Inversely proportional to tissue thickness
7
Q
State the equation for velocity of diffusion across a membrane.
ANSWERS:
This is Fick’s law multiplied by a diffusion constant.
8
Q
State Graham’s law of diffusion.
ANSWERS:
Rates at which gases diffuse are inversely proportional to the square
root of their densities.
9
Q
Which two factors affect the diffusion constant of a gas in a liquid?
ANSWERS:
, Solubility
Molecular Mass (Square Root)
10
Q
What is the thickness of the respiratory membrane in a normal
healthy lung?
ANSWERS:
0.5-1.0 µm
11
Q
What is the transit time for a red blood cell to pass through a
pulmonary capillary?
ANSWERS:
0.75 s
NOTE: CO2 diffusion is complete in 0.10 s and O2 diffusion is complete
in 0.30-0.40 s.
12
Q
State the steps to derive the equation for lung diffusion capacity.
ANSWERS:
Diffusion capacity incorporates the structural factors that affect
diffusion (i.e. diffusion coefficient, area and thickness).
Based on the Fick equation: