NR 293 Endocrine Pharmacology Practice Pack 2026 |Chamberlain
College
1. A patient is prescribed levothyroxine for hypothyroidism. Which instruction
should the nurse provide regarding administration?
A. Take the medication in the morning on an empty stomach.
B. Take the medication at bedtime with a snack.
C. Take the medication with a full meal to avoid GI upset.
D. Take the medication only when symptoms of fatigue occur.
Answer: A
Rationale: Levothyroxine should be taken in the morning on an empty stomach, at least 30
to 60 minutes before breakfast, to ensure optimal absorption.
2. Which type of insulin has the fastest onset of action?
A. Insulin Glargine
B. Regular Insulin
C. NPH Insulin
D. Insulin Lispro
Answer: D
Rationale: Insulin Lispro is a rapid-acting insulin with an onset of 15 minutes, whereas
Regular is short-acting (30-60 mins).
,3. A patient taking long-term prednisone therapy is at risk for which condition if
the drug is stopped abruptly?
A. Thyroid storm
B. Adrenal crisis
C. Hypoglycemic shock
D. Hyperkalemia
Answer: B
Rationale: Abrupt withdrawal of corticosteroids can lead to acute adrenal insufficiency
(adrenal crisis) because the body’s natural cortisol production has been suppressed.
4. Which laboratory value is the most important to monitor for a patient
receiving Metformin?
A. Glomerular Filtration Rate (GFR)
B. Serum Potassium
C. Serum Sodium
D. Platelet count
Answer: A
Rationale: Metformin is excreted by the kidneys; impaired renal function (low GFR)
increases the risk of lactic acidosis.
5. A nurse is teaching a patient about drawing up NPH and Regular insulin in the
same syringe. What is the correct sequence?
A. NPH first, then Regular.
B. It does not matter which is first.
C. Regular first, then NPH.
D. They should never be mixed in the same syringe.
Answer: C
Rationale: To prevent contaminating the short-acting (clear) insulin with the long-acting
(cloudy) insulin, the ‘Clear before Cloudy’ rule is followed.
, 6. What is the primary mechanism of action of Propylthiouracil (PTU)?
A. It destroys the thyroid gland tissue.
B. It stimulates the release of TSH.
C. It inhibits the synthesis of thyroid hormones.
D. It increases the peripheral conversion of T4 to T3.
Answer: C
Rationale: PTU is an antithyroid drug that inhibits the synthesis of thyroid hormones by
blocking the oxidation of iodine.
7. A patient on prednisone is experiencing ‘Cushingoid’ side effects. Which of
the following is a classic sign?
A. Moon face and buffalo hump.
B. Hypotension and bradycardia.
C. Weight loss and hypoglycemia.
D. Increased muscle mass in the extremities.
Answer: A
Rationale: Cushingoid features include fat redistribution resulting in a moon face, buffalo
hump, and truncal obesity.
8. Insulin Glargine (Lantus) is best described as having which peak time?
A. 1 to 2 hours.
B. 4 to 8 hours.
C. No pronounced peak.
D. 12 to 16 hours.
Answer: C
Rationale: Insulin Glargine is a long-acting insulin that provides a basal level of insulin
over 24 hours with no significant peak.
College
1. A patient is prescribed levothyroxine for hypothyroidism. Which instruction
should the nurse provide regarding administration?
A. Take the medication in the morning on an empty stomach.
B. Take the medication at bedtime with a snack.
C. Take the medication with a full meal to avoid GI upset.
D. Take the medication only when symptoms of fatigue occur.
Answer: A
Rationale: Levothyroxine should be taken in the morning on an empty stomach, at least 30
to 60 minutes before breakfast, to ensure optimal absorption.
2. Which type of insulin has the fastest onset of action?
A. Insulin Glargine
B. Regular Insulin
C. NPH Insulin
D. Insulin Lispro
Answer: D
Rationale: Insulin Lispro is a rapid-acting insulin with an onset of 15 minutes, whereas
Regular is short-acting (30-60 mins).
,3. A patient taking long-term prednisone therapy is at risk for which condition if
the drug is stopped abruptly?
A. Thyroid storm
B. Adrenal crisis
C. Hypoglycemic shock
D. Hyperkalemia
Answer: B
Rationale: Abrupt withdrawal of corticosteroids can lead to acute adrenal insufficiency
(adrenal crisis) because the body’s natural cortisol production has been suppressed.
4. Which laboratory value is the most important to monitor for a patient
receiving Metformin?
A. Glomerular Filtration Rate (GFR)
B. Serum Potassium
C. Serum Sodium
D. Platelet count
Answer: A
Rationale: Metformin is excreted by the kidneys; impaired renal function (low GFR)
increases the risk of lactic acidosis.
5. A nurse is teaching a patient about drawing up NPH and Regular insulin in the
same syringe. What is the correct sequence?
A. NPH first, then Regular.
B. It does not matter which is first.
C. Regular first, then NPH.
D. They should never be mixed in the same syringe.
Answer: C
Rationale: To prevent contaminating the short-acting (clear) insulin with the long-acting
(cloudy) insulin, the ‘Clear before Cloudy’ rule is followed.
, 6. What is the primary mechanism of action of Propylthiouracil (PTU)?
A. It destroys the thyroid gland tissue.
B. It stimulates the release of TSH.
C. It inhibits the synthesis of thyroid hormones.
D. It increases the peripheral conversion of T4 to T3.
Answer: C
Rationale: PTU is an antithyroid drug that inhibits the synthesis of thyroid hormones by
blocking the oxidation of iodine.
7. A patient on prednisone is experiencing ‘Cushingoid’ side effects. Which of
the following is a classic sign?
A. Moon face and buffalo hump.
B. Hypotension and bradycardia.
C. Weight loss and hypoglycemia.
D. Increased muscle mass in the extremities.
Answer: A
Rationale: Cushingoid features include fat redistribution resulting in a moon face, buffalo
hump, and truncal obesity.
8. Insulin Glargine (Lantus) is best described as having which peak time?
A. 1 to 2 hours.
B. 4 to 8 hours.
C. No pronounced peak.
D. 12 to 16 hours.
Answer: C
Rationale: Insulin Glargine is a long-acting insulin that provides a basal level of insulin
over 24 hours with no significant peak.
