NR 293 Pharmacology - Week 1 Comprehensive Quiz 2026
|Chamberlain College
1. Which phase of pharmacokinetics involves the movement of a drug from its
site of administration into the blood?
A. Metabolism
B. Absorption
C. Distribution
D. Excretion
Answer: B
Rationale: Absorption is the process of a drug moving from the administration site into the
bloodstream.
2. A nurse is preparing to administer an oral medication. Which factor
significantly reduces the amount of drug available to the systemic circulation?
A. Plasma protein binding
B. First-pass effect
C. Drug-drug interaction
D. Glomerular filtration
Answer: B
Rationale: The first-pass effect occurs in the liver where oral drugs are metabolized before
reaching systemic circulation, reducing bioavailability.
,3. A drug has a half-life of 4 hours. If a dose of 100 mg is given, how much drug
remains in the body after 12 hours?
A. 50 mg
B. 25 mg
C. 12.5 mg
D. 6.25 mg
Answer: C
Rationale: After 4 hours (1 half-life), 50mg remains; after 8 hours (2 half-lives), 25mg
remains; after 12 hours (3 half-lives), 12.5mg remains.
4. Which route of medication administration provides the fastest onset of
action?
A. Intravenous
B. Subcutaneous
C. Intramuscular
D. Oral
Answer: A
Rationale: Intravenous administration enters the bloodstream directly, bypassing
absorption barriers and providing immediate onset.
5. A patient with low serum albumin levels is at risk for which complication
when taking protein-bound drugs?
A. Drug toxicity
B. Reduced drug effectiveness
C. Rapid excretion
D. Increased first-pass metabolism
Answer: A
Rationale: Low albumin means fewer binding sites, resulting in more free, active drug in
the blood, which increases the risk of toxicity.
, 6. The nurse is teaching a patient how to take a sublingual medication. Which
instruction is correct?
A. Swallow the tablet with a full glass of water.
B. Crush the tablet and mix it with applesauce.
C. Chew the tablet before swallowing to speed up absorption.
D. Place the tablet under the tongue and let it dissolve completely.
Answer: D
Rationale: Sublingual medications must dissolve under the tongue to be absorbed through
the highly vascular mucosa directly into the bloodstream.
7. A drug that mimics the action of a receptor by binding to it is known as an:
A. Agonist
B. Antagonist
C. Inhibitor
D. Enzyme inducer
Answer: A
Rationale: An agonist binds to a receptor and produces a response that mimics the
endogenous substance.
8. Which schedule of controlled substances has the highest potential for abuse
and no currently accepted medical use?
A. Schedule III
B. Schedule II
C. Schedule I
D. Schedule V
Answer: C
Rationale: Schedule I drugs have high abuse potential and no accepted medical use (e.g.,
heroin, LSD).
|Chamberlain College
1. Which phase of pharmacokinetics involves the movement of a drug from its
site of administration into the blood?
A. Metabolism
B. Absorption
C. Distribution
D. Excretion
Answer: B
Rationale: Absorption is the process of a drug moving from the administration site into the
bloodstream.
2. A nurse is preparing to administer an oral medication. Which factor
significantly reduces the amount of drug available to the systemic circulation?
A. Plasma protein binding
B. First-pass effect
C. Drug-drug interaction
D. Glomerular filtration
Answer: B
Rationale: The first-pass effect occurs in the liver where oral drugs are metabolized before
reaching systemic circulation, reducing bioavailability.
,3. A drug has a half-life of 4 hours. If a dose of 100 mg is given, how much drug
remains in the body after 12 hours?
A. 50 mg
B. 25 mg
C. 12.5 mg
D. 6.25 mg
Answer: C
Rationale: After 4 hours (1 half-life), 50mg remains; after 8 hours (2 half-lives), 25mg
remains; after 12 hours (3 half-lives), 12.5mg remains.
4. Which route of medication administration provides the fastest onset of
action?
A. Intravenous
B. Subcutaneous
C. Intramuscular
D. Oral
Answer: A
Rationale: Intravenous administration enters the bloodstream directly, bypassing
absorption barriers and providing immediate onset.
5. A patient with low serum albumin levels is at risk for which complication
when taking protein-bound drugs?
A. Drug toxicity
B. Reduced drug effectiveness
C. Rapid excretion
D. Increased first-pass metabolism
Answer: A
Rationale: Low albumin means fewer binding sites, resulting in more free, active drug in
the blood, which increases the risk of toxicity.
, 6. The nurse is teaching a patient how to take a sublingual medication. Which
instruction is correct?
A. Swallow the tablet with a full glass of water.
B. Crush the tablet and mix it with applesauce.
C. Chew the tablet before swallowing to speed up absorption.
D. Place the tablet under the tongue and let it dissolve completely.
Answer: D
Rationale: Sublingual medications must dissolve under the tongue to be absorbed through
the highly vascular mucosa directly into the bloodstream.
7. A drug that mimics the action of a receptor by binding to it is known as an:
A. Agonist
B. Antagonist
C. Inhibitor
D. Enzyme inducer
Answer: A
Rationale: An agonist binds to a receptor and produces a response that mimics the
endogenous substance.
8. Which schedule of controlled substances has the highest potential for abuse
and no currently accepted medical use?
A. Schedule III
B. Schedule II
C. Schedule I
D. Schedule V
Answer: C
Rationale: Schedule I drugs have high abuse potential and no accepted medical use (e.g.,
heroin, LSD).
