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HESI 400 RN EXIT EXAM – Comprehensive Study Guide with Rationales (Practice Questions)

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This document provides a complete HESI 400 RN Exit Exam study guide covering high-yield nursing content with detailed practice questions and answer rationales. It includes medication calculations, gastrointestinal, cardiovascular, respiratory, neurological, renal, endocrine, pharmacology, pediatrics, maternity, mental health, oncology, safety, delegation, and nursing management topics. Each question is structured in NCLEX-style format with clear explanations to strengthen clinical reasoning and exam readiness. The material is designed to support final-stage nursing students preparing for the RN exit exam by reinforcing prioritization, critical thinking, and safe patient care decision-making.

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HESI 400 RN EXIT EXAM
COMPREHENSIVE
STUDY GUIDE

SECTION 1: MEDICATION CALCULATIONS



QUESTION 1

Potassium chloride 25 mEq in 500 mL D5W to infuse over 6 hours. Available: 10 mEq/5mL.
How many mL to add?

ANSWER

12.5 mL

RATIONALE / EXPLANATION

Using formula D/H × Q: 25 mEq ÷ 10 mEq × 5 mL = 12.5 mL



QUESTION 2

Morphine Sulfate Oral Solution 38 mg PO q4h PRN. Available: 100 mg/5 mL (20 mg/mL).
How many mL?

ANSWER

1.9 mL

RATIONALE / EXPLANATION

38 mg ÷ 20 mg/mL = 1.9 mL



QUESTION 3

Promethazine 0.5 mg/kg IM for 42 lb child. Available: 25 mg/mL. How many mL?

ANSWER

0.4 mL

RATIONALE / EXPLANATION

42 lbs ÷ 2.2 = 19.09 kg. 0.5 mg × 19.09 kg = 9.545 mg. 9.545 mg ÷ 25 mg/mL = 0.38 → 0.4 mL


Page 1 of 31

,QUESTION 4

Heparin protocol 18 units/kg/hr for 144 lb client. Available: 25,000 units/250 mL D5W. mL/hr?

ANSWER

12 mL/hr

RATIONALE / EXPLANATION

144 lbs ÷ 2.2 = 65 kg. 65 kg × 18 units/kg/hr = 1170 units/hr. 25000 units/250 mL = 100 units/mL.
1170 ÷ 100 = 11.7 → 12 mL/hr




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, SECTION 2: GASTROINTESTINAL



QUESTION 5

Older client with chronic constipation on furosemide and laxatives. Suggestions? (Select all)

ANSWER

Include oatmeal with stewed prunes for breakfast
Increase fluid intake by keeping water glass next to recliner
Recommend seeking help with regular shopping and meal preparation

RATIONALE / EXPLANATION

Older adults at higher risk for constipation due to decreased GI muscle tone. Oatmeal/prunes
increase fiber; fluids decrease constipation; meal prep assistance improves diet quality.



QUESTION 6

Client post-cholecystectomy 2 weeks ago with nausea, abdominal distention, pain. First
assessment?

ANSWER

Auscultate all quadrants of the abdomen

RATIONALE / EXPLANATION

Assess bowel sounds first to evaluate GI function before other assessments.



QUESTION 7

Which task can nurse delegate to UAP for client with NG tube?

ANSWER

Disconnect the NG suction so the client can ambulate in the hallway

RATIONALE / EXPLANATION

UAP can disconnect/reconnect NG suction for ambulation. Cannot replace, secure if displaced,
or manipulate tube placement.



QUESTION 8

Page 3 of 31

, Sucralfate (Carafate) scheduled for 0900 after breakfast. Action?

ANSWER

Hold until later - give before next meal

RATIONALE / EXPLANATION

Carafate coats mucosal lining and should be given BEFORE meals, not after.




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