CMN 548 UNIT 5 EXAM REVIEW;
QUESTIONS WITH DETAILED VERIFIED
ANSWERS; ALREADY GRADED A; 2026
4 major transmitters - correct answer- Dopamine,
Serotonin, GABA, Norepinephrine
A pt reports SE of "visual trails". What does this mean? -
correct answer- Visual trails: seeing an after image when
looking at moving objects or when moving one's head quickly
A single dose of MAOIs may persist in its inhibition of MAO for
how long? - correct answer- because they irreversibly
inactivate MAOs, the therapeutic effect of a single dose of
irreversible MAOIs may persist for as long as 2 weeks
Agonist (full agonist) - correct answer- A drug that binds
to a specific receptor producing an effect identical to that
usually produced by the neurotransmitter affecting that receptor
Although typical antipsychotics are associated w/ EPS
syndromes, their use is still considered as they differ from newer
atypical agents in that they do not have what risk associated
,with them? - correct answer- A reason to still consider
DRAs is their lower risk of causing significant metabolic
abnormalities, such as weight gain, lipid elevations and diabetes
Antagonist - correct answer- A compound that blinds to
a receptor that blocks or reduces the action of another
substance at the receptor site
Anticholinergic effects of TCAs at plasma levels > 300mg/ml can
cause what? - correct answer- Confusion
disorientation
delirium
delusion
hallucinations (more commonly in elderly)
Black Box Warning - correct answer- This warning
reflects that a medication may cause a serious or even life-
threatening side effect
Bupropion (Wellbutrin) action? - correct answer-
bupropion inhibits the reuptake of NE and at higher doses, DA.
This class of medication does not act upon the 5-HT system.
-MOA may involve the presynaptic release of NE and DA
,Children with OCD may be prescribed one of two SSRIs? -
correct answer- Fluvoxamine (favelin, Luvox)
Sertraline (zoloft)
Classification of DRAs? Pharmacological classification? -
correct answer- FIRST generation antipsychotic (LOW
potency):
-chlorpromazine (Thorazine)
-Prochlorperazine (Compazine)-rarely used as antipsychotic
-Thioridazine (Mellaril)
FIRST generation antipsychotic (HIGH potency):
-Fluphenazine (Prolixin)
-Pimozide (Orap)
-Thiothixene (Navane)
-Haloperidol (haldol)
Complications for using MAOIs for pts who have bipolar I and
schizophrenia? - correct answer- induction of mania in
the depressed phase of bipolar I disorder and triggering of a
psychotic decompensation in persons with schizophrenia
, Describe symptoms of central anticholinergic effects that DRAs
can cause? - correct answer- Severe agitation,
disorientation to time, person and place; hallucinations;
seizures; fever and dilated pupils. Stupor and coma may follow
Describe tx resistance in pts with psychotic d/o? What is
recommended for these pts? - correct answer- -10-35%
of persons with schizophrenia don't obtain significant benefit
from antipsychotic drugs
-tx resistance is a failure on at least TWO adequate trials of
antipsychotics from TWO pharmacological classes
-Useful to get plasma concentration b/c it is possible that they
are slow or rapid metabolizers, or are not taking their meds
-Clozapine is a recommended as it has been conclusively shown
to be effective when given to pts who have failed multiple trials
of DRAs.
Discuss potential SE on plasma concentrations with concurrent
use of bupropion and carbamazepine (Tegretol); discuss
potential plasma concentration effects with concurrent use of
bupropion and valproic acid (depakene)? - correct answer-
carbamazepine(Tegretol) may INCREASE plasma concentrations
of bupropion.
QUESTIONS WITH DETAILED VERIFIED
ANSWERS; ALREADY GRADED A; 2026
4 major transmitters - correct answer- Dopamine,
Serotonin, GABA, Norepinephrine
A pt reports SE of "visual trails". What does this mean? -
correct answer- Visual trails: seeing an after image when
looking at moving objects or when moving one's head quickly
A single dose of MAOIs may persist in its inhibition of MAO for
how long? - correct answer- because they irreversibly
inactivate MAOs, the therapeutic effect of a single dose of
irreversible MAOIs may persist for as long as 2 weeks
Agonist (full agonist) - correct answer- A drug that binds
to a specific receptor producing an effect identical to that
usually produced by the neurotransmitter affecting that receptor
Although typical antipsychotics are associated w/ EPS
syndromes, their use is still considered as they differ from newer
atypical agents in that they do not have what risk associated
,with them? - correct answer- A reason to still consider
DRAs is their lower risk of causing significant metabolic
abnormalities, such as weight gain, lipid elevations and diabetes
Antagonist - correct answer- A compound that blinds to
a receptor that blocks or reduces the action of another
substance at the receptor site
Anticholinergic effects of TCAs at plasma levels > 300mg/ml can
cause what? - correct answer- Confusion
disorientation
delirium
delusion
hallucinations (more commonly in elderly)
Black Box Warning - correct answer- This warning
reflects that a medication may cause a serious or even life-
threatening side effect
Bupropion (Wellbutrin) action? - correct answer-
bupropion inhibits the reuptake of NE and at higher doses, DA.
This class of medication does not act upon the 5-HT system.
-MOA may involve the presynaptic release of NE and DA
,Children with OCD may be prescribed one of two SSRIs? -
correct answer- Fluvoxamine (favelin, Luvox)
Sertraline (zoloft)
Classification of DRAs? Pharmacological classification? -
correct answer- FIRST generation antipsychotic (LOW
potency):
-chlorpromazine (Thorazine)
-Prochlorperazine (Compazine)-rarely used as antipsychotic
-Thioridazine (Mellaril)
FIRST generation antipsychotic (HIGH potency):
-Fluphenazine (Prolixin)
-Pimozide (Orap)
-Thiothixene (Navane)
-Haloperidol (haldol)
Complications for using MAOIs for pts who have bipolar I and
schizophrenia? - correct answer- induction of mania in
the depressed phase of bipolar I disorder and triggering of a
psychotic decompensation in persons with schizophrenia
, Describe symptoms of central anticholinergic effects that DRAs
can cause? - correct answer- Severe agitation,
disorientation to time, person and place; hallucinations;
seizures; fever and dilated pupils. Stupor and coma may follow
Describe tx resistance in pts with psychotic d/o? What is
recommended for these pts? - correct answer- -10-35%
of persons with schizophrenia don't obtain significant benefit
from antipsychotic drugs
-tx resistance is a failure on at least TWO adequate trials of
antipsychotics from TWO pharmacological classes
-Useful to get plasma concentration b/c it is possible that they
are slow or rapid metabolizers, or are not taking their meds
-Clozapine is a recommended as it has been conclusively shown
to be effective when given to pts who have failed multiple trials
of DRAs.
Discuss potential SE on plasma concentrations with concurrent
use of bupropion and carbamazepine (Tegretol); discuss
potential plasma concentration effects with concurrent use of
bupropion and valproic acid (depakene)? - correct answer-
carbamazepine(Tegretol) may INCREASE plasma concentrations
of bupropion.
