MOLECULAR CELL BIOLOGY FINAL PAPER
2026 TESTED QUESTIONS WITH FULL
SOLUTION GRADED A+
◉ Which of the following is NOT true about the HGP:
a. Goals were to understand human genome structure, gene
organization, gene regulation, gene variation and disease
susceptibility
b. After many years and completion of the sequencing, the project
has been discontinued
c. Draft of genome sequence was completed ahead of schedule and
under budget
d. All of the above are true about the HGP Answer: b. After many
years and completion of the sequencing, the project has been
discontinued
◉ Most DNA in the human genome includes Answer: transposable
elements
,◉ Thanks to the HGP we now know the functions of all protein
coding genes. This statement is: Answer: False
◉ Which high through put solid surface-based sequencing technique
involves detection of light flashes emitted every time a nucleotide is
added to a growing DNA strand? Answer: Pyrosequencing
◉ Orthologs are: Answer: homologous genes (homologs) in different
species
◉ A particular set of SNPs that tend to be inherited together is called
Answer: haplotype
◉ DNA sequence analysis of whole populations of microorganisms is
called Answer: metagenomics
◉ Used in proteomics studies
a. DNA microarrays
b. RNA-seq
c. 2-D SDS-PAGE Answer: 2-D SDS-PAGE
,◉ Used in transcriptomics studies
a. RNA seq
b. 2-D SDS-PAGE
c. DNA Microarrays
d. Both a. & c. Answer: d. Both a. & c.
◉ DNA microarray data presentation Answer: Heat map
◉ Provides snap shot of gene expression at time of sample
preparation Answer: transcriptomics
◉ Proteomics evaluation of a well-established cell culture is
expected to yield the same results at all time points of sample
extraction. This statement is: Answer: False
◉ Which of the following features of DNA organization do
eukaryotes and prokaryotes have in common?
, a. Electron microscope images reveal a "beads-on-a-string"
appearance
b. DNA is associated with positively charged basic proteins
c. DNA is organized into linear chromosomes
d. DNA compaction of ~850 times is sufficient for packaging within
cells Answer: b. DNA is associated with positively charged basic
proteins
◉ Which of the following is a sequencing method that has allowed
for miniaturization and increased high throughput analysis by
distributing clusters of DNA segments on a solid surface?
a. Automated Sanger method
b. Pyrosequencing method
c. Classical Sanger method
d. Maxam and Gilbert method Answer: Pyrosequencing method
2026 TESTED QUESTIONS WITH FULL
SOLUTION GRADED A+
◉ Which of the following is NOT true about the HGP:
a. Goals were to understand human genome structure, gene
organization, gene regulation, gene variation and disease
susceptibility
b. After many years and completion of the sequencing, the project
has been discontinued
c. Draft of genome sequence was completed ahead of schedule and
under budget
d. All of the above are true about the HGP Answer: b. After many
years and completion of the sequencing, the project has been
discontinued
◉ Most DNA in the human genome includes Answer: transposable
elements
,◉ Thanks to the HGP we now know the functions of all protein
coding genes. This statement is: Answer: False
◉ Which high through put solid surface-based sequencing technique
involves detection of light flashes emitted every time a nucleotide is
added to a growing DNA strand? Answer: Pyrosequencing
◉ Orthologs are: Answer: homologous genes (homologs) in different
species
◉ A particular set of SNPs that tend to be inherited together is called
Answer: haplotype
◉ DNA sequence analysis of whole populations of microorganisms is
called Answer: metagenomics
◉ Used in proteomics studies
a. DNA microarrays
b. RNA-seq
c. 2-D SDS-PAGE Answer: 2-D SDS-PAGE
,◉ Used in transcriptomics studies
a. RNA seq
b. 2-D SDS-PAGE
c. DNA Microarrays
d. Both a. & c. Answer: d. Both a. & c.
◉ DNA microarray data presentation Answer: Heat map
◉ Provides snap shot of gene expression at time of sample
preparation Answer: transcriptomics
◉ Proteomics evaluation of a well-established cell culture is
expected to yield the same results at all time points of sample
extraction. This statement is: Answer: False
◉ Which of the following features of DNA organization do
eukaryotes and prokaryotes have in common?
, a. Electron microscope images reveal a "beads-on-a-string"
appearance
b. DNA is associated with positively charged basic proteins
c. DNA is organized into linear chromosomes
d. DNA compaction of ~850 times is sufficient for packaging within
cells Answer: b. DNA is associated with positively charged basic
proteins
◉ Which of the following is a sequencing method that has allowed
for miniaturization and increased high throughput analysis by
distributing clusters of DNA segments on a solid surface?
a. Automated Sanger method
b. Pyrosequencing method
c. Classical Sanger method
d. Maxam and Gilbert method Answer: Pyrosequencing method
