USMLE STEP 2 CK PRACTICE LATEST EXAM 2026
UPDATE 100 QUESTIONS AND DETAILED VERIFIED
ANSWERS FROM ACTUAL EXAMS TEST GRADE A+
1. A 65-year-old man presents with chest pain radiating to the left arm,
diaphoresis, and nausea. ECG shows ST elevation in leads II, III, and aVF. What is
the most likely diagnosis?
Answer: Inferior wall myocardial infarction
Rationale: ST elevation in II, III, aVF indicates inferior MI, usually due to RCA
occlusion.
2. A 23-year-old woman has fever, dysuria, and flank pain. CVA tenderness is
present. What is the most likely diagnosis?
Answer: Acute pyelonephritis
Rationale: Fever + CVA tenderness + urinary symptoms indicates kidney infection.
3. A newborn has a holosystolic murmur at the left lower sternal border and
Down syndrome. Diagnosis?
Answer: Atrioventricular septal defect (AV canal defect)
Rationale: Strong association between Down syndrome and AV septal defects.
4. A patient has tremor, weight loss, heat intolerance, and exophthalmos.
Diagnosis?
Answer: Graves disease
Rationale: Hyperthyroidism with eye findings indicates Graves disease.
,5. A 45-year-old alcoholic presents with epigastric pain radiating to the back.
Diagnosis?
Answer: Acute pancreatitis
Rationale: Alcohol use + epigastric pain radiating to back is classic pancreatitis.
6. A child has barking cough and inspiratory stridor. Diagnosis?
Answer: Croup (laryngotracheobronchitis)
Rationale: Parainfluenza virus causes barking cough and stridor.
7. A woman presents with butterfly rash worsened by sunlight. Diagnosis?
Answer: Systemic lupus erythematosus (SLE)
Rationale: Photosensitive malar rash is classic for SLE.
8. A patient has chronic cough, night sweats, and hemoptysis. Diagnosis?
Answer: Tuberculosis
Rationale: Constitutional symptoms + hemoptysis suggests TB.
9. A man has resting tremor, bradykinesia, and shuffling gait. Diagnosis?
Answer: Parkinson disease
Rationale: Dopamine deficiency causes movement disorder.
10. A woman has severe right lower quadrant pain and missed period.
Pregnancy test positive. Diagnosis?
Answer: Ectopic pregnancy
Rationale: Positive pregnancy test + RLQ pain suggests tubal pregnancy.
, 11. A child has a “slapped cheek” rash. Diagnosis?
Answer: Erythema infectiosum (Parvovirus B19)
Rationale: Classic facial rash in children.
12. A patient has painless hematuria and smoking history. Most likely diagnosis?
Answer: Bladder cancer
Rationale: Painless gross hematuria is bladder cancer until proven otherwise.
13. A newborn has microcephaly, rash, and cataracts after maternal infection.
Cause?
Answer: Congenital rubella syndrome
Rationale: Rubella causes congenital cataracts and deafness.
14. A patient has chronic diarrhea and weight loss; stool shows fat. Diagnosis?
Answer: Celiac disease
Rationale: Malabsorption with steatorrhea.
15. A woman has tremor, palpitations, and heat intolerance. TSH is low.
Diagnosis?
Answer: Hyperthyroidism
Rationale: Low TSH indicates thyroid overactivity.
16. A patient has severe crushing chest pain relieved by nitroglycerin. Diagnosis?
Answer: Angina pectoris
Rationale: Stable angina improves with nitrates.
UPDATE 100 QUESTIONS AND DETAILED VERIFIED
ANSWERS FROM ACTUAL EXAMS TEST GRADE A+
1. A 65-year-old man presents with chest pain radiating to the left arm,
diaphoresis, and nausea. ECG shows ST elevation in leads II, III, and aVF. What is
the most likely diagnosis?
Answer: Inferior wall myocardial infarction
Rationale: ST elevation in II, III, aVF indicates inferior MI, usually due to RCA
occlusion.
2. A 23-year-old woman has fever, dysuria, and flank pain. CVA tenderness is
present. What is the most likely diagnosis?
Answer: Acute pyelonephritis
Rationale: Fever + CVA tenderness + urinary symptoms indicates kidney infection.
3. A newborn has a holosystolic murmur at the left lower sternal border and
Down syndrome. Diagnosis?
Answer: Atrioventricular septal defect (AV canal defect)
Rationale: Strong association between Down syndrome and AV septal defects.
4. A patient has tremor, weight loss, heat intolerance, and exophthalmos.
Diagnosis?
Answer: Graves disease
Rationale: Hyperthyroidism with eye findings indicates Graves disease.
,5. A 45-year-old alcoholic presents with epigastric pain radiating to the back.
Diagnosis?
Answer: Acute pancreatitis
Rationale: Alcohol use + epigastric pain radiating to back is classic pancreatitis.
6. A child has barking cough and inspiratory stridor. Diagnosis?
Answer: Croup (laryngotracheobronchitis)
Rationale: Parainfluenza virus causes barking cough and stridor.
7. A woman presents with butterfly rash worsened by sunlight. Diagnosis?
Answer: Systemic lupus erythematosus (SLE)
Rationale: Photosensitive malar rash is classic for SLE.
8. A patient has chronic cough, night sweats, and hemoptysis. Diagnosis?
Answer: Tuberculosis
Rationale: Constitutional symptoms + hemoptysis suggests TB.
9. A man has resting tremor, bradykinesia, and shuffling gait. Diagnosis?
Answer: Parkinson disease
Rationale: Dopamine deficiency causes movement disorder.
10. A woman has severe right lower quadrant pain and missed period.
Pregnancy test positive. Diagnosis?
Answer: Ectopic pregnancy
Rationale: Positive pregnancy test + RLQ pain suggests tubal pregnancy.
, 11. A child has a “slapped cheek” rash. Diagnosis?
Answer: Erythema infectiosum (Parvovirus B19)
Rationale: Classic facial rash in children.
12. A patient has painless hematuria and smoking history. Most likely diagnosis?
Answer: Bladder cancer
Rationale: Painless gross hematuria is bladder cancer until proven otherwise.
13. A newborn has microcephaly, rash, and cataracts after maternal infection.
Cause?
Answer: Congenital rubella syndrome
Rationale: Rubella causes congenital cataracts and deafness.
14. A patient has chronic diarrhea and weight loss; stool shows fat. Diagnosis?
Answer: Celiac disease
Rationale: Malabsorption with steatorrhea.
15. A woman has tremor, palpitations, and heat intolerance. TSH is low.
Diagnosis?
Answer: Hyperthyroidism
Rationale: Low TSH indicates thyroid overactivity.
16. A patient has severe crushing chest pain relieved by nitroglycerin. Diagnosis?
Answer: Angina pectoris
Rationale: Stable angina improves with nitrates.
