1|Page
NURS 5433 FNP II MIDTERM 2026 | FAMILY
NURSE PRACTITIONER | 200+ PRACTICE
QUESTIONS & RATIONALES | HIGH-YIELD |
PASS FIRST ATTEMPT
## Table of Contents
1. **Advanced Health Assessment & Differential Diagnosis** (Q1–
Q25)
2. **Primary Care of Adults – Chronic Disease Management** (Q26–
Q50)
3. **Primary Care of Geriatrics** (Q51–Q65)
4. **Primary Care of Children & Adolescents** (Q66–Q85)
5. **Women’s Health** (Q86–Q105)
6. **Men’s Health** (Q106–Q115)
7. **Pharmacology for FNP Practice** (Q116–Q140)
8. **Preventive Care & Health Promotion** (Q141–Q155)
9. **Mental Health in Primary Care** (Q156–Q170)
10. **Evidence-Based Practice & Clinical Guidelines** (Q171–Q180)
11. **High-Yield NGN/Scenario-Based Questions** (Q181–Q200)
---
,2|Page
# Section 1: Advanced Health Assessment & Differential Diagnosis
(Q1–Q25)
**Q1.** A 55-year-old male presents with substernal chest pressure that
occurs with exertion and is relieved by rest. The pain radiates to the left
arm and jaw. Which diagnosis is most likely?
A. Stable angina
B. Unstable angina
C. Musculoskeletal chest pain
D. Pericarditis
**Correct Answer: A – Stable angina**
*Rationale: Exertion-induced chest pain relieved by rest is classic for
stable angina.*
**Q2.** A 30-year-old female presents with episodic palpitations,
sweating, headache, and hypertension. These episodes occur randomly
and last 10–15 minutes. Which diagnosis should be considered?
A. Pheochromocytoma
B. Panic disorder
C. Hyperthyroidism
D. Cardiac arrhythmia
,3|Page
**Correct Answer: A – Pheochromocytoma**
*Rationale: Paroxysmal hypertension, headache, palpitations, and
diaphoresis are classic for pheochromocytoma.*
**Q3.** A 45-year-old male presents with a painful, red, swollen left
great toe that started suddenly overnight. He denies trauma. Which
diagnosis is most likely?
A. Gout
B. Pseudogout
C. Septic arthritis
D. Osteoarthritis
**Correct Answer: A – Gout**
*Rationale: Sudden onset of monoarticular arthritis of the first MTP
joint is classic for gout.*
**Q4.** A 68-year-old female reports waking up at night with shortness
of breath that improves when she sits up. She has a history of
hypertension. What is the most likely diagnosis?
A. Paroxysmal nocturnal dyspnea (PND) from heart failure
B. COPD
C. Asthma
D. GERD
, 4|Page
**Correct Answer: A – Paroxysmal nocturnal dyspnea (PND) from heart
failure**
*Rationale: PND is a classic symptom of left-sided heart failure.*
**Q5.** On fundoscopic exam, you see sharp optic disc margins,
arteriovenous nicking, and copper-wire arteries. This is consistent with:
A. Hypertensive retinopathy
B. Diabetic retinopathy
C. Papilledema
D. Glaucoma
**Correct Answer: A – Hypertensive retinopathy**
*Rationale: AV nicking and copper/silver wiring are signs of chronic
hypertension.*
**Q6.** A patient has a positive Murphy’s sign (inspiratory arrest on
RUQ palpation). This is most consistent with:
A. Acute cholecystitis
B. Appendicitis
C. Pancreatitis
D. Peptic ulcer disease
**Correct Answer: A – Acute cholecystitis**
NURS 5433 FNP II MIDTERM 2026 | FAMILY
NURSE PRACTITIONER | 200+ PRACTICE
QUESTIONS & RATIONALES | HIGH-YIELD |
PASS FIRST ATTEMPT
## Table of Contents
1. **Advanced Health Assessment & Differential Diagnosis** (Q1–
Q25)
2. **Primary Care of Adults – Chronic Disease Management** (Q26–
Q50)
3. **Primary Care of Geriatrics** (Q51–Q65)
4. **Primary Care of Children & Adolescents** (Q66–Q85)
5. **Women’s Health** (Q86–Q105)
6. **Men’s Health** (Q106–Q115)
7. **Pharmacology for FNP Practice** (Q116–Q140)
8. **Preventive Care & Health Promotion** (Q141–Q155)
9. **Mental Health in Primary Care** (Q156–Q170)
10. **Evidence-Based Practice & Clinical Guidelines** (Q171–Q180)
11. **High-Yield NGN/Scenario-Based Questions** (Q181–Q200)
---
,2|Page
# Section 1: Advanced Health Assessment & Differential Diagnosis
(Q1–Q25)
**Q1.** A 55-year-old male presents with substernal chest pressure that
occurs with exertion and is relieved by rest. The pain radiates to the left
arm and jaw. Which diagnosis is most likely?
A. Stable angina
B. Unstable angina
C. Musculoskeletal chest pain
D. Pericarditis
**Correct Answer: A – Stable angina**
*Rationale: Exertion-induced chest pain relieved by rest is classic for
stable angina.*
**Q2.** A 30-year-old female presents with episodic palpitations,
sweating, headache, and hypertension. These episodes occur randomly
and last 10–15 minutes. Which diagnosis should be considered?
A. Pheochromocytoma
B. Panic disorder
C. Hyperthyroidism
D. Cardiac arrhythmia
,3|Page
**Correct Answer: A – Pheochromocytoma**
*Rationale: Paroxysmal hypertension, headache, palpitations, and
diaphoresis are classic for pheochromocytoma.*
**Q3.** A 45-year-old male presents with a painful, red, swollen left
great toe that started suddenly overnight. He denies trauma. Which
diagnosis is most likely?
A. Gout
B. Pseudogout
C. Septic arthritis
D. Osteoarthritis
**Correct Answer: A – Gout**
*Rationale: Sudden onset of monoarticular arthritis of the first MTP
joint is classic for gout.*
**Q4.** A 68-year-old female reports waking up at night with shortness
of breath that improves when she sits up. She has a history of
hypertension. What is the most likely diagnosis?
A. Paroxysmal nocturnal dyspnea (PND) from heart failure
B. COPD
C. Asthma
D. GERD
, 4|Page
**Correct Answer: A – Paroxysmal nocturnal dyspnea (PND) from heart
failure**
*Rationale: PND is a classic symptom of left-sided heart failure.*
**Q5.** On fundoscopic exam, you see sharp optic disc margins,
arteriovenous nicking, and copper-wire arteries. This is consistent with:
A. Hypertensive retinopathy
B. Diabetic retinopathy
C. Papilledema
D. Glaucoma
**Correct Answer: A – Hypertensive retinopathy**
*Rationale: AV nicking and copper/silver wiring are signs of chronic
hypertension.*
**Q6.** A patient has a positive Murphy’s sign (inspiratory arrest on
RUQ palpation). This is most consistent with:
A. Acute cholecystitis
B. Appendicitis
C. Pancreatitis
D. Peptic ulcer disease
**Correct Answer: A – Acute cholecystitis**
