Psychopharmacology - Wilkes
Actual Questions and Answers
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Multiple-Choice (A–D), For Each Question.
Each Question Includes The Correct Answer
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### 1. What is one form of Naltrexone delivery method limited to inpatient use?
Answer: Implant.
Explanation: Naltrexone implants are administered in a medical setting where patients
require monitoring as the medication is released gradually into the body, ensuring adherence
and minimizing relapse after treatment commencement.
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### 2. What is the mechanism of action of buprenorphine?
Answer: Mu receptor partial agonist for opioid withdrawal.
Explanation: Buprenorphine acts on the mu-opioid receptors as a partial agonist, alleviating
withdrawal symptoms and cravings while providing a ceiling effect that reduces the risk of
respiratory depression, making it safer than full agonists.
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### 3. What medication taken too soon after last opioid use increases the chances of intense
withdrawal that comes on very quickly (precipitated withdrawal)?
Answer: Buprenorphine.
Explanation: Initiating Buprenorphine when significant opioid levels remain can cause rapid
withdrawal due to its partial agonist properties. This leads users into a challenging situation
where withdrawal symptoms may suddenly intensify, necessitating careful planning of
treatments.
,### 4. What is the mechanism of action of Naloxone?
Answer: Naloxone is a pure opioid antagonist that competes and displaces opioids at receptor
sites.
Explanation: Naloxone reverses the effects of opioid overdose by binding to the same mu-
opioid receptors in the central nervous system without activating them, effectively displacing
any opioid present. Its rapid action makes it critical in emergency situations to restore
normal breathing in opioid overdose cases.
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### 5. What medications treat opioid use disorder?
Answer: Methadone; Buprenorphine; Buprenorphine + Naloxone.
Explanation: These medications facilitate recovery from opioid use disorder (OUD).
Methadone is a long-acting opioid agonist, while Buprenorphine is a partial agonist that
lowers the risk of overdose. The combination of Buprenorphine with Naloxone is designed to
prevent misuse by causing withdrawal symptoms if the patient tries to inject it.
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### 6. What medication for opioid use disorder is used with comorbid pain?
Answer: Buprenorphine + Naloxone.
, Explanation: Buprenorphine is a suitable option because it provides adequate relief for opioid
withdrawal and chronic pain through its partial agonist properties without the full’s opioid
effects, hence reducing the potential for dependency.
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### 7. Inappropriate use of what substance may be due to uncontrolled pain?
Answer: Opioids.
Explanation: Patients experiencing unmanaged pain are more likely to misuse opioids to
achieve pain relief. This misuse can lead to addiction and further complications, emphasizing
the importance of effective pain management.
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### 8. What are the Naltrexone delivery methods?
Answer: Tablet; Injectable; Implant.
Explanation: Naltrexone can be administered orally, through injection, or as an implant.
Each method serves to help manage cravings and reduce relapse rates in treating alcohol and
opioid use disorders, with longer-acting forms providing sustained support.
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### 9. What are symptoms of opioid intoxication?