PHM 431 Exam 3 with all Correct & 100% Verified
Answers |Latest Update |Already Graded A+
amphetamine ✔Correct Answer-not a substrate for MAO but it is for VMAT
stored in vesicles as a false transmitter
false transmitter ✔Correct Answer-Released as a transmitter but it cannot activate receptors
NE B receptor ✔Correct Answer-stimulatory G protein receptor, activates Gs, which activates
adenylate cyclase
Gs ✔Correct Answer-activates adenylate cyclase
NE a receptor ✔Correct Answer-produces Gi, which inhibits adenylate cyclase
D1 dopamine receptir ✔Correct Answer-activates Gs which causes an excitatory response by
activating adenylate cyclase
D2 dopamine receptor ✔Correct Answer-activates Gi which causes an inhibitory response
Pseudoephedrine ✔Correct Answer-the active ingredient in sudafed and other nasal
decongestants. it is the stereoisomer of ephedrine
Ephedrine/Pseudoephedrine ✔Correct Answer-the methyl group protects from oxidation and
makes these compounds orally active
not metabolites for MAO or COMT because the hydroxyl groups are missing
Pseudoephrine to methamphetamine ✔Correct Answer-need LiAlH4 or Pd/C
requires hydrogenation of OH groups and dehalogenation
euphoric effects of amphetamine ✔Correct Answer-mediated via activation of the mesolimbic
dopamine system. Causes dopamine release in the nucleus accumbens
drug wanting ✔Correct Answer-correlated with personality traits of exploratory excitability
and novelty seeking
amphetamine and satiety ✔Correct Answer-causes CART peptides to be induced, CART
peptides inhibit feeding behavior caused by neuropeptide Y
increase in NPY ✔Correct Answer-increase in feeding
, CART peptides ✔Correct Answer-found in the mesolimbic dopamine system and the
hypothalamus
contribute to the appetite suppressing effects of amphetamine
5q13-14 locus ✔Correct Answer-a site that has been associated with susceptibility to obesity
ritalin ✔Correct Answer-large bulky substituents make it orally active
increases activity in ventral tegmental area
increases dopamine release in frontal cortex and caudate putamen
helps to focus patient on decision making
MDMA side effects ✔Correct Answer-hyperthermia and hyponatremia
locus ceruleus ✔Correct Answer-Amphetamines increase attention and awareness by the user
of his or her environment. The brain region affected by amphetamine that mediates this
response is the
CART peptides ✔Correct Answer-Weight gain is a predictor for nicotine relapse after a
smoking cessation treatment. Which of the following might be useful as an adjunct treatment
that would minimize weight gain in a subject who is trying to quit cigarettes?
prefrontal cortex ✔Correct Answer-PCP treatment of laboratory rats produces behavioral
changes that mimic schizophrenia. In PCP-treated rats, antipsychotic drugs like chlorpromazine
restore normal functioning of the thalamus but not the:
cross tolerance ✔Correct Answer-Caffeine and theobromine
dimethyltryptamine ✔Correct Answer-Disruption of processing of sensory information in the
thalamus is a mechanism of action of which of the following drugs?
Inhibition of alpha-synuclein aggregation in enteric neurons ✔Correct Answer-It is well
established that coffee consumption protects against Parkinson's disease by an unknown
mechanism. One hypothesis that has been proposed to explain this beneficial effect is:
hypothalamus ✔Correct Answer-amphetamine suppressing appetite
methylphenidate ✔Correct Answer-not a substrate for the VMAT
Amphetamine is a false neurotransmitter because ✔Correct Answer-It is a substrate for VMAT
but it is not an agonist at dopamine receptors
Catechol-O-methyl transferase ✔Correct Answer-an enzyme found in the liver that is
responsible for degradation of catecholamines found in the diet and absorbed from the small
intestine
Answers |Latest Update |Already Graded A+
amphetamine ✔Correct Answer-not a substrate for MAO but it is for VMAT
stored in vesicles as a false transmitter
false transmitter ✔Correct Answer-Released as a transmitter but it cannot activate receptors
NE B receptor ✔Correct Answer-stimulatory G protein receptor, activates Gs, which activates
adenylate cyclase
Gs ✔Correct Answer-activates adenylate cyclase
NE a receptor ✔Correct Answer-produces Gi, which inhibits adenylate cyclase
D1 dopamine receptir ✔Correct Answer-activates Gs which causes an excitatory response by
activating adenylate cyclase
D2 dopamine receptor ✔Correct Answer-activates Gi which causes an inhibitory response
Pseudoephedrine ✔Correct Answer-the active ingredient in sudafed and other nasal
decongestants. it is the stereoisomer of ephedrine
Ephedrine/Pseudoephedrine ✔Correct Answer-the methyl group protects from oxidation and
makes these compounds orally active
not metabolites for MAO or COMT because the hydroxyl groups are missing
Pseudoephrine to methamphetamine ✔Correct Answer-need LiAlH4 or Pd/C
requires hydrogenation of OH groups and dehalogenation
euphoric effects of amphetamine ✔Correct Answer-mediated via activation of the mesolimbic
dopamine system. Causes dopamine release in the nucleus accumbens
drug wanting ✔Correct Answer-correlated with personality traits of exploratory excitability
and novelty seeking
amphetamine and satiety ✔Correct Answer-causes CART peptides to be induced, CART
peptides inhibit feeding behavior caused by neuropeptide Y
increase in NPY ✔Correct Answer-increase in feeding
, CART peptides ✔Correct Answer-found in the mesolimbic dopamine system and the
hypothalamus
contribute to the appetite suppressing effects of amphetamine
5q13-14 locus ✔Correct Answer-a site that has been associated with susceptibility to obesity
ritalin ✔Correct Answer-large bulky substituents make it orally active
increases activity in ventral tegmental area
increases dopamine release in frontal cortex and caudate putamen
helps to focus patient on decision making
MDMA side effects ✔Correct Answer-hyperthermia and hyponatremia
locus ceruleus ✔Correct Answer-Amphetamines increase attention and awareness by the user
of his or her environment. The brain region affected by amphetamine that mediates this
response is the
CART peptides ✔Correct Answer-Weight gain is a predictor for nicotine relapse after a
smoking cessation treatment. Which of the following might be useful as an adjunct treatment
that would minimize weight gain in a subject who is trying to quit cigarettes?
prefrontal cortex ✔Correct Answer-PCP treatment of laboratory rats produces behavioral
changes that mimic schizophrenia. In PCP-treated rats, antipsychotic drugs like chlorpromazine
restore normal functioning of the thalamus but not the:
cross tolerance ✔Correct Answer-Caffeine and theobromine
dimethyltryptamine ✔Correct Answer-Disruption of processing of sensory information in the
thalamus is a mechanism of action of which of the following drugs?
Inhibition of alpha-synuclein aggregation in enteric neurons ✔Correct Answer-It is well
established that coffee consumption protects against Parkinson's disease by an unknown
mechanism. One hypothesis that has been proposed to explain this beneficial effect is:
hypothalamus ✔Correct Answer-amphetamine suppressing appetite
methylphenidate ✔Correct Answer-not a substrate for the VMAT
Amphetamine is a false neurotransmitter because ✔Correct Answer-It is a substrate for VMAT
but it is not an agonist at dopamine receptors
Catechol-O-methyl transferase ✔Correct Answer-an enzyme found in the liver that is
responsible for degradation of catecholamines found in the diet and absorbed from the small
intestine
