CPPS 304 EXAM SCRIPT 2026
COMPLETE QUESTIONS ACCURATE
ANSWERS
◉ What gene is a characteristic of poor drug metabolizers? Answer:
CYP 450 2D6
◉ What type of receptors facilitate actions of growth factors in
stimulating cell division? Answer: Tyrosine Kinase Receptors
◉ What type of inhibitors are used as growth factor inhibitors in various
cancers? Answer: Tyrosine Kinase Inhibitors
◉ What happens to a patient if they have a TKR mutation (T790M)?
Answer: The binding site for the drug changes and the patient stops
responding
◉ What are 3 barriers to pharmacogenetic implementation? (List format)
Answer: 1. Redundancy
2. Drugs with PK and PD polymorphisms (ex. warfarin)
3. Information overload
◉ Personalized medicine is not just about pharmacogenetics. It also
deals more broadly with the idea that drug therapy should be be tailored
,to each patient. What is the term for this idea? Answer: Precision
Medicine
◉ What common feature do all new approaches in drug therapy have in
common? Answer: They are made/inspired from biologics
◉ What are three examples of biologics? (List format) Answer: 1.
peptides
2. proteins
3. antibodies
◉ What are MAbs? Answer: monoclonal antibodies
◉ What were early MAbs derived from? Answer: animals (murines)
◉ What are Chimeric MAbs? Answer: mixed animal/human
◉ What are Humanized MAbs? Answer: mostly human (95%)
◉ What are Fully Human MAbs? Answer: fully human (100%)
◉ True or False? MAbs typically bind either to a receptor or bind a
ligand. Answer: True
, ◉ What are the 4 pieces of nomenclature in MAbs? (List format)
Answer: 1. Up to imagination
2. Therapeutic target
3. Source
4. Monoclonal antibody
◉ All MAbs end in what? Answer: mab
◉ What is Bevacizumab? Answer: A MAb that is used to treat colon
cancer
◉ What is the brand name for Bevacizumab? Answer: Avastin
◉ What does VEGF stand for? Answer: vascular endothelial growth
factor
◉ Why is VEGF an issue in tumours? Answer: It is an angiogenic
growth factor that is overexpressed in tumours
◉ How does bevacizumab work? Answer: it binds VEGF and inhibits
angiogenesis
◉ What are 3 applications for MAbs? Answer: immune system
disorders, cancers, many others
COMPLETE QUESTIONS ACCURATE
ANSWERS
◉ What gene is a characteristic of poor drug metabolizers? Answer:
CYP 450 2D6
◉ What type of receptors facilitate actions of growth factors in
stimulating cell division? Answer: Tyrosine Kinase Receptors
◉ What type of inhibitors are used as growth factor inhibitors in various
cancers? Answer: Tyrosine Kinase Inhibitors
◉ What happens to a patient if they have a TKR mutation (T790M)?
Answer: The binding site for the drug changes and the patient stops
responding
◉ What are 3 barriers to pharmacogenetic implementation? (List format)
Answer: 1. Redundancy
2. Drugs with PK and PD polymorphisms (ex. warfarin)
3. Information overload
◉ Personalized medicine is not just about pharmacogenetics. It also
deals more broadly with the idea that drug therapy should be be tailored
,to each patient. What is the term for this idea? Answer: Precision
Medicine
◉ What common feature do all new approaches in drug therapy have in
common? Answer: They are made/inspired from biologics
◉ What are three examples of biologics? (List format) Answer: 1.
peptides
2. proteins
3. antibodies
◉ What are MAbs? Answer: monoclonal antibodies
◉ What were early MAbs derived from? Answer: animals (murines)
◉ What are Chimeric MAbs? Answer: mixed animal/human
◉ What are Humanized MAbs? Answer: mostly human (95%)
◉ What are Fully Human MAbs? Answer: fully human (100%)
◉ True or False? MAbs typically bind either to a receptor or bind a
ligand. Answer: True
, ◉ What are the 4 pieces of nomenclature in MAbs? (List format)
Answer: 1. Up to imagination
2. Therapeutic target
3. Source
4. Monoclonal antibody
◉ All MAbs end in what? Answer: mab
◉ What is Bevacizumab? Answer: A MAb that is used to treat colon
cancer
◉ What is the brand name for Bevacizumab? Answer: Avastin
◉ What does VEGF stand for? Answer: vascular endothelial growth
factor
◉ Why is VEGF an issue in tumours? Answer: It is an angiogenic
growth factor that is overexpressed in tumours
◉ How does bevacizumab work? Answer: it binds VEGF and inhibits
angiogenesis
◉ What are 3 applications for MAbs? Answer: immune system
disorders, cancers, many others
