RED BLOOD CELL INDICES, ERYTHROPOIESIS,
HAEMOGLOBIN SYNTHESIS
COURSE LECTURER: DR. AKANINYENE
, ERYTHROPOIESIS
•Erythropoiesis is the process which encompasses the origin,
development, maturation and release of erythrocytes into
the circulation.
•The burst-forming unit erythroid (BFUE) which is committed
to the red blood cell line pass through different stages and
finally become the matured RBCs
•During these stages four important changes are noticed.
Reduction in diameter of Disappearance of Appearance of
cell from about 20 to 7.2 μ nucleoli and nucleus hemoglobin
Change in the staining
properties of the cytoplasm
, STAGES OF ERYTHROPIESIS
•Various stages between CFU-E cells and matured RBCs are:
, Proerythroblast (Megaloblast)
•Proerythroblast or megaloblast is the first cell derived
from CFU-E.
•It is very large in size with a diameter of about 20 μ. Its
nucleus is large and occupies the cell almost completely.
•The nucleus has two or more nucleoli and a reticular
network.
•Proerythroblast does not contain hemoglobin. The
cytoplasm is basophilic in nature. Proerythroblast multiplies
several times and finally forms the cell of next stage called
early normoblast.
HAEMOGLOBIN SYNTHESIS
COURSE LECTURER: DR. AKANINYENE
, ERYTHROPOIESIS
•Erythropoiesis is the process which encompasses the origin,
development, maturation and release of erythrocytes into
the circulation.
•The burst-forming unit erythroid (BFUE) which is committed
to the red blood cell line pass through different stages and
finally become the matured RBCs
•During these stages four important changes are noticed.
Reduction in diameter of Disappearance of Appearance of
cell from about 20 to 7.2 μ nucleoli and nucleus hemoglobin
Change in the staining
properties of the cytoplasm
, STAGES OF ERYTHROPIESIS
•Various stages between CFU-E cells and matured RBCs are:
, Proerythroblast (Megaloblast)
•Proerythroblast or megaloblast is the first cell derived
from CFU-E.
•It is very large in size with a diameter of about 20 μ. Its
nucleus is large and occupies the cell almost completely.
•The nucleus has two or more nucleoli and a reticular
network.
•Proerythroblast does not contain hemoglobin. The
cytoplasm is basophilic in nature. Proerythroblast multiplies
several times and finally forms the cell of next stage called
early normoblast.
