GCSE
OCR GCSE
(9–1)
OCR
Page GCSE
(9–1)
Combined
1TITLE (9–1)
TITLECombined
Science
2025
2025 Combined
TITLE
OCRScience
OCR AGCSE
(Gateway
2025
GCSE Science
APackage
OCR (Gateway
Science)
PackageA (Gateway
GCSE Science)
Deal |J250-08
Package
Deal Science)
J250-08
Biology
Complete
| Complete
Deal J250-08
| ExamBiology
Higher
Complete
Exam Biology
Higher
TierPapers
Question
Question
Exam –
Higher
Tier
June
–
Question
Papers 2025
Tier
with June
with –
PapersMorning
2025
MarkingJune
Marking
with Morning
2025
Complete
Schemes,Morning
Schemes,
Marking Complete
Question
Complete
Foundation
Schemes,
FoundationQuestion
Paper
Question
Foundation
&&Higher
Higher&
Paper
Marking
Tier
&
Tier &
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BundleScheme.pdf
Bundle & Bundle
Tier Marking
Scheme.pdf
Schem
2025 OCR GCSE Combined Science A (Gateway Science)
J250/08 Biology (Higher Tier)
Complete Question paper with Marking Scheme Combined
Monday 9 June 2025 – Morning
GCSE (9–1) Combined Science A
(Gateway Science)
J250/08 Biology (Higher Tier)
Time allowed: 1 hour 10 minutes
You must have:
• a ruler (cm/mm)
You can use:
• a scientific or graphical calculator
• an HB pencil
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be
given for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 60.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 24 pages.
ADVICE
• Read each question carefully before you start your answer.
© OCR 2025 [601/8687/2] OCR is an exempt Charity
DC (EV/CT) 353361/4 Turn over
OCR
OCR
GCSE
GCSE
OCR
(9–1)
GCSE
(9–1)
Combined
(9–1)
Combined
Combined
Science
Science
A Science
(Gateway
A (Gateway
A (Gateway
Science)
Science)
J250-08
Science)
J250-08
Biology
J250-08
Biology
Higher
Biology
Higher
TierHigher
Tier
––
June
Tier
June
2025
–2025
June
Morning
Morning
2025Complete
Morning
Complete
Complete
Question
Question
Paper
Question
Paper
& Marking
&
Paper
Marking
&Scheme
Marking
Scheme.pdf
Schem
, GCSE
OCR GCSE
(9–1)
OCR
Page GCSE
(9–1)
Combined
2TITLE (9–1)
TITLECombined
Science
2025
2025 Combined
TITLE
OCRScience
OCR AGCSE
(Gateway
2025
GCSE Science
APackage
OCR (Gateway
Science)
PackageA (Gateway
GCSE Science)
Deal |J250-08
Package
Deal Science)
J250-08
Biology
Complete
| Complete
Deal J250-08
| ExamBiology
Higher
Complete
Exam Biology
Higher
TierPapers
Question
Question
Exam –
Higher
Tier
June
–
Question
Papers 2025
Tier
with June
with –
PapersMorning
2025
MarkingJune
Marking
with Morning
2025
Complete
Schemes,Morning
Schemes,
Marking Complete
Question
Complete
Foundation
Schemes,
FoundationQuestion
Paper
Question
Foundation
&&Higher
Higher&
Paper
Marking
Tier
&
Tier &
Paper
Marking
Higher
BundleScheme.pdf
Bundle & Bundle
Tier Marking
Scheme.pdf
Schem
2
Section A
You should spend a maximum of 20 minutes on this section.
Write your answer to each question in the box provided.
1 The diagram shows a genetic cross for inheriting cystic fibrosis.
Cystic fibrosis is a recessive inherited condition.
Egg
Cc
Sperm
Cc
C c
C C CC Cc
c c cC cc
What percentage of the offspring will have cystic fibrosis?
A 0%
B 25%
C 75%
D 100%
Your answer [1]
© OCR 2025
OCR
OCR
GCSE
GCSE
OCR
(9–1)
GCSE
(9–1)
Combined
(9–1)
Combined
Combined
Science
Science
A Science
(Gateway
A (Gateway
A (Gateway
Science)
Science)
J250-08
Science)
J250-08
Biology
J250-08
Biology
Higher
Biology
Higher
TierHigher
Tier
––
June
Tier
June
2025
–2025
June
Morning
Morning
2025Complete
Morning
Complete
Complete
Question
Question
Paper
Question
Paper
& Marking
&
Paper
Marking
&Scheme
Marking
Scheme.pdf
Schem
, GCSE
OCR GCSE
(9–1)
OCR
Page GCSE
(9–1)
Combined
3TITLE (9–1)
TITLECombined
Science
2025
2025 Combined
TITLE
OCRScience
OCR AGCSE
(Gateway
2025
GCSE Science
APackage
OCR (Gateway
Science)
PackageA (Gateway
GCSE Science)
Deal |J250-08
Package
Deal Science)
J250-08
Biology
Complete
| Complete
Deal J250-08
| ExamBiology
Higher
Complete
Exam Biology
Higher
TierPapers
Question
Question
Exam –
Higher
Tier
June
–
Question
Papers 2025
Tier
with June
with –
PapersMorning
2025
MarkingJune
Marking
with Morning
2025
Complete
Schemes,Morning
Schemes,
Marking Complete
Question
Complete
Foundation
Schemes,
FoundationQuestion
Paper
Question
Foundation
&&Higher
Higher&
Paper
Marking
Tier
&
Tier &
Paper
Marking
Higher
BundleScheme.pdf
Bundle & Bundle
Tier Marking
Scheme.pdf
Schem
3
2 Which pathway shows how nitrates are used by plants to make proteins?
A Nitrates amino acids proteins
B Nitrates carbohydrates proteins
C Nitrates DNA proteins
D Nitrates fatty acids proteins
Your answer [1]
3 Which term describes the interaction between the biotic and abiotic factors in the environment?
A Community
B Ecosystem
C Habitat
D Species
Your answer [1]
© OCR 2025 Turn over
OCR
OCR
GCSE
GCSE
OCR
(9–1)
GCSE
(9–1)
Combined
(9–1)
Combined
Combined
Science
Science
A Science
(Gateway
A (Gateway
A (Gateway
Science)
Science)
J250-08
Science)
J250-08
Biology
J250-08
Biology
Higher
Biology
Higher
TierHigher
Tier
––
June
Tier
June
2025
–2025
June
Morning
Morning
2025Complete
Morning
Complete
Complete
Question
Question
Paper
Question
Paper
& Marking
&
Paper
Marking
&Scheme
Marking
Scheme.pdf
Schem
, GCSE
OCR GCSE
(9–1)
OCR
Page GCSE
(9–1)
Combined
4TITLE (9–1)
TITLECombined
Science
2025
2025 Combined
TITLE
OCRScience
OCR AGCSE
(Gateway
2025
GCSE Science
APackage
OCR (Gateway
Science)
PackageA (Gateway
GCSE Science)
Deal |J250-08
Package
Deal Science)
J250-08
Biology
Complete
| Complete
Deal J250-08
| ExamBiology
Higher
Complete
Exam Biology
Higher
TierPapers
Question
Question
Exam –
Higher
Tier
June
–
Question
Papers 2025
Tier
with June
with –
PapersMorning
2025
MarkingJune
Marking
with Morning
2025
Complete
Schemes,Morning
Schemes,
Marking Complete
Question
Complete
Foundation
Schemes,
FoundationQuestion
Paper
Question
Foundation
&&Higher
Higher&
Paper
Marking
Tier
&
Tier &
Paper
Marking
Higher
BundleScheme.pdf
Bundle & Bundle
Tier Marking
Scheme.pdf
Schem
4
4 Water is recycled in the environment.
Which process increases the level of water in the atmosphere?
A Condensation
B Precipitation
C Translocation
D Transpiration
Your answer [1]
5 New drugs are tested in clinical trials.
A placebo looks like the drug being tested but has no medical effect.
Which row is the correct description for a double-blind placebo trial?
All patients receive the Patient and doctors know
drug who takes the drug
A no yes
B no no
C yes yes
D yes no
Your answer [1]
© OCR 2025
OCR
OCR
GCSE
GCSE
OCR
(9–1)
GCSE
(9–1)
Combined
(9–1)
Combined
Combined
Science
Science
A Science
(Gateway
A (Gateway
A (Gateway
Science)
Science)
J250-08
Science)
J250-08
Biology
J250-08
Biology
Higher
Biology
Higher
TierHigher
Tier
––
June
Tier
June
2025
–2025
June
Morning
Morning
2025Complete
Morning
Complete
Complete
Question
Question
Paper
Question
Paper
& Marking
&
Paper
Marking
&Scheme
Marking
Scheme.pdf
Schem
OCR GCSE
(9–1)
OCR
Page GCSE
(9–1)
Combined
1TITLE (9–1)
TITLECombined
Science
2025
2025 Combined
TITLE
OCRScience
OCR AGCSE
(Gateway
2025
GCSE Science
APackage
OCR (Gateway
Science)
PackageA (Gateway
GCSE Science)
Deal |J250-08
Package
Deal Science)
J250-08
Biology
Complete
| Complete
Deal J250-08
| ExamBiology
Higher
Complete
Exam Biology
Higher
TierPapers
Question
Question
Exam –
Higher
Tier
June
–
Question
Papers 2025
Tier
with June
with –
PapersMorning
2025
MarkingJune
Marking
with Morning
2025
Complete
Schemes,Morning
Schemes,
Marking Complete
Question
Complete
Foundation
Schemes,
FoundationQuestion
Paper
Question
Foundation
&&Higher
Higher&
Paper
Marking
Tier
&
Tier &
Paper
Marking
Higher
BundleScheme.pdf
Bundle & Bundle
Tier Marking
Scheme.pdf
Schem
2025 OCR GCSE Combined Science A (Gateway Science)
J250/08 Biology (Higher Tier)
Complete Question paper with Marking Scheme Combined
Monday 9 June 2025 – Morning
GCSE (9–1) Combined Science A
(Gateway Science)
J250/08 Biology (Higher Tier)
Time allowed: 1 hour 10 minutes
You must have:
• a ruler (cm/mm)
You can use:
• a scientific or graphical calculator
• an HB pencil
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be
given for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 60.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 24 pages.
ADVICE
• Read each question carefully before you start your answer.
© OCR 2025 [601/8687/2] OCR is an exempt Charity
DC (EV/CT) 353361/4 Turn over
OCR
OCR
GCSE
GCSE
OCR
(9–1)
GCSE
(9–1)
Combined
(9–1)
Combined
Combined
Science
Science
A Science
(Gateway
A (Gateway
A (Gateway
Science)
Science)
J250-08
Science)
J250-08
Biology
J250-08
Biology
Higher
Biology
Higher
TierHigher
Tier
––
June
Tier
June
2025
–2025
June
Morning
Morning
2025Complete
Morning
Complete
Complete
Question
Question
Paper
Question
Paper
& Marking
&
Paper
Marking
&Scheme
Marking
Scheme.pdf
Schem
, GCSE
OCR GCSE
(9–1)
OCR
Page GCSE
(9–1)
Combined
2TITLE (9–1)
TITLECombined
Science
2025
2025 Combined
TITLE
OCRScience
OCR AGCSE
(Gateway
2025
GCSE Science
APackage
OCR (Gateway
Science)
PackageA (Gateway
GCSE Science)
Deal |J250-08
Package
Deal Science)
J250-08
Biology
Complete
| Complete
Deal J250-08
| ExamBiology
Higher
Complete
Exam Biology
Higher
TierPapers
Question
Question
Exam –
Higher
Tier
June
–
Question
Papers 2025
Tier
with June
with –
PapersMorning
2025
MarkingJune
Marking
with Morning
2025
Complete
Schemes,Morning
Schemes,
Marking Complete
Question
Complete
Foundation
Schemes,
FoundationQuestion
Paper
Question
Foundation
&&Higher
Higher&
Paper
Marking
Tier
&
Tier &
Paper
Marking
Higher
BundleScheme.pdf
Bundle & Bundle
Tier Marking
Scheme.pdf
Schem
2
Section A
You should spend a maximum of 20 minutes on this section.
Write your answer to each question in the box provided.
1 The diagram shows a genetic cross for inheriting cystic fibrosis.
Cystic fibrosis is a recessive inherited condition.
Egg
Cc
Sperm
Cc
C c
C C CC Cc
c c cC cc
What percentage of the offspring will have cystic fibrosis?
A 0%
B 25%
C 75%
D 100%
Your answer [1]
© OCR 2025
OCR
OCR
GCSE
GCSE
OCR
(9–1)
GCSE
(9–1)
Combined
(9–1)
Combined
Combined
Science
Science
A Science
(Gateway
A (Gateway
A (Gateway
Science)
Science)
J250-08
Science)
J250-08
Biology
J250-08
Biology
Higher
Biology
Higher
TierHigher
Tier
––
June
Tier
June
2025
–2025
June
Morning
Morning
2025Complete
Morning
Complete
Complete
Question
Question
Paper
Question
Paper
& Marking
&
Paper
Marking
&Scheme
Marking
Scheme.pdf
Schem
, GCSE
OCR GCSE
(9–1)
OCR
Page GCSE
(9–1)
Combined
3TITLE (9–1)
TITLECombined
Science
2025
2025 Combined
TITLE
OCRScience
OCR AGCSE
(Gateway
2025
GCSE Science
APackage
OCR (Gateway
Science)
PackageA (Gateway
GCSE Science)
Deal |J250-08
Package
Deal Science)
J250-08
Biology
Complete
| Complete
Deal J250-08
| ExamBiology
Higher
Complete
Exam Biology
Higher
TierPapers
Question
Question
Exam –
Higher
Tier
June
–
Question
Papers 2025
Tier
with June
with –
PapersMorning
2025
MarkingJune
Marking
with Morning
2025
Complete
Schemes,Morning
Schemes,
Marking Complete
Question
Complete
Foundation
Schemes,
FoundationQuestion
Paper
Question
Foundation
&&Higher
Higher&
Paper
Marking
Tier
&
Tier &
Paper
Marking
Higher
BundleScheme.pdf
Bundle & Bundle
Tier Marking
Scheme.pdf
Schem
3
2 Which pathway shows how nitrates are used by plants to make proteins?
A Nitrates amino acids proteins
B Nitrates carbohydrates proteins
C Nitrates DNA proteins
D Nitrates fatty acids proteins
Your answer [1]
3 Which term describes the interaction between the biotic and abiotic factors in the environment?
A Community
B Ecosystem
C Habitat
D Species
Your answer [1]
© OCR 2025 Turn over
OCR
OCR
GCSE
GCSE
OCR
(9–1)
GCSE
(9–1)
Combined
(9–1)
Combined
Combined
Science
Science
A Science
(Gateway
A (Gateway
A (Gateway
Science)
Science)
J250-08
Science)
J250-08
Biology
J250-08
Biology
Higher
Biology
Higher
TierHigher
Tier
––
June
Tier
June
2025
–2025
June
Morning
Morning
2025Complete
Morning
Complete
Complete
Question
Question
Paper
Question
Paper
& Marking
&
Paper
Marking
&Scheme
Marking
Scheme.pdf
Schem
, GCSE
OCR GCSE
(9–1)
OCR
Page GCSE
(9–1)
Combined
4TITLE (9–1)
TITLECombined
Science
2025
2025 Combined
TITLE
OCRScience
OCR AGCSE
(Gateway
2025
GCSE Science
APackage
OCR (Gateway
Science)
PackageA (Gateway
GCSE Science)
Deal |J250-08
Package
Deal Science)
J250-08
Biology
Complete
| Complete
Deal J250-08
| ExamBiology
Higher
Complete
Exam Biology
Higher
TierPapers
Question
Question
Exam –
Higher
Tier
June
–
Question
Papers 2025
Tier
with June
with –
PapersMorning
2025
MarkingJune
Marking
with Morning
2025
Complete
Schemes,Morning
Schemes,
Marking Complete
Question
Complete
Foundation
Schemes,
FoundationQuestion
Paper
Question
Foundation
&&Higher
Higher&
Paper
Marking
Tier
&
Tier &
Paper
Marking
Higher
BundleScheme.pdf
Bundle & Bundle
Tier Marking
Scheme.pdf
Schem
4
4 Water is recycled in the environment.
Which process increases the level of water in the atmosphere?
A Condensation
B Precipitation
C Translocation
D Transpiration
Your answer [1]
5 New drugs are tested in clinical trials.
A placebo looks like the drug being tested but has no medical effect.
Which row is the correct description for a double-blind placebo trial?
All patients receive the Patient and doctors know
drug who takes the drug
A no yes
B no no
C yes yes
D yes no
Your answer [1]
© OCR 2025
OCR
OCR
GCSE
GCSE
OCR
(9–1)
GCSE
(9–1)
Combined
(9–1)
Combined
Combined
Science
Science
A Science
(Gateway
A (Gateway
A (Gateway
Science)
Science)
J250-08
Science)
J250-08
Biology
J250-08
Biology
Higher
Biology
Higher
TierHigher
Tier
––
June
Tier
June
2025
–2025
June
Morning
Morning
2025Complete
Morning
Complete
Complete
Question
Question
Paper
Question
Paper
& Marking
&
Paper
Marking
&Scheme
Marking
Scheme.pdf
Schem
