PHM 350 EXAM 1 QUESTIONS WITH ALL CORRECT &
100% VERIFIED ANSWERS |LATEST VERSION |ALREADY
GRADED A+
If the volume of distribution of a drug is calculated to be the same as plasma volume, then one
should conclude that:
A. The drug has been eliminated before plasma drug concentration was measured.
B. The drug did not leave the systemic circulation.
C. The drug is present in the blood and the extracellular extravascular space but is absent from
the intracellular space.
D. The drug is sequestered to cells of a single organ or to a specific organelle within cells.
E. None of the above ✔Correct Answer-B
The Therapeutic Range of a drug:
A. Is the range of plasma concentration of the drug in which the drug produces the desired
therapeutic without producing any toxic effects or adverse side effects also produced.
B. Can only be determined for antagonist drugs.
C. Can only be determined for agonist drugs.
D. Is the range of plasma concentration of the drug in which the drug produces the desired
therapeutic effect regardless of any toxic effects or adverse side effects also produced
✔Correct Answer-A
The bioavailability of a drug administered orally (and swallowed!!!) is 0.9. Given this
information, you conclude that for an orally administered dose of this drug:
A. This drug is rapidly eliminated.
B. This drug is slowly eliminated.
C. Most of an orally administered dose of this drug is absorbed into the blood.
D. This drug will likely have insignificant therapeutic benefits if those benefits require the drug
to enter the systemic ✔Correct Answer-C
The Kd for a drug is:
A. Defined as the concentration of drug necessary to product 50% of the maximum response
when receptors are activated
B. Defined as the concentration of drug at which 50% of the receptors in a given population will
each be bound by a molecule of the drug (with the remaining receptors being unoccupied by
drug)
C. Defined as the concentration of drug required to inhibit an agonist response by 50%
assuming sufficient agonist s present to produce a response that is 100% of the maximum
response
D. Defined as the concentration of drug necessary to inhibit agonist binding by 50% assuming
sufficient agonist is present to bind to 100% of the receptors ✔Correct Answer-B
,You are given the same oral dose of a drug every 24 hours. By the sixth day, the drug seems to
have a reduced effectiveness (compared to its effect on the first couple of days). This reduced
effectiveness could be the result of:
A. Increased rate of delivery of the drug from the plasma to its sites of action and increased
affinity of the drug for the receptors through which the response is induced.
B. Increased affinity of the drug for the receptors through which the response is induced.
C. Increased rate of delivery of the drug from the plasma to its sites of action.
D. Decreased absorption of drug from the gastrointestinal tract.
E. Decreased rate of elimination ✔Correct Answer-D
The liver enzyme Enzyme Z metabolizes Drug A. If Drug A is administered repeatedly, then the
amount of Enzyme Z in the liver is increased. Consequently....
A. The rate of metabolism of Drug A will not change.
B. The rate of metabolism of any drug metabolized by Enzyme Z is decreased.
C. The half-life of all drugs metabolized by Enzyme Z will be decreased
D. The half-life of Drug A will be increased.
E. The half-life of Drug B, also metabolized by Enzyme Z, will not be affected ✔Correct
Answer-C
When a drug is dissolved in an aqueous (water-based) solution, the concentration of ionized
form of the drug is dependent on:
A. The acidity (pH) of the aqueous solution.
B. The lipid solubility of the drug.
C. The pKa of the drug.
D. The amount of drug dissolved in the solution.
E. The acidity (pH) of the aqueous solution, and the pKa of the drug, and the amount of the
drug dissolved in the solution ✔Correct Answer-E
Drug A is administered repeatedly with a constant interval between consecutive doses and with
a constant dose. The mean plasma concentration of Drug A is measured. The concentration:
A. Is independent on the route of administration but is dependent on the dose and the interval
between consecutive doses.
B. Is independent of the clearance volume for the drug.
C. Is independent of the route of administration
D. Is independent of the dose of drug administered but not of the interval between consecutive
doses
E. Is dependent on the dose and the interval between consecutive doses ✔Correct Answer-E
The therapeutic threshold concentration (aka minimal effective concentration) of a drug:
A. Determines the pharmacological and clinical (or physiological) efficacies of the drug.
B. Is affected by the ability of the body to eliminate (metabolize and/or excrete) the drug and
depends on the rate of absorption of the drug.
C. Depends on the rate of absorption of the drug.
, D. Is affected by the ability of the body to eliminate (metabolize and/or excrete) the drug.
E. Is the minimum plasma concentration of the drug which is required to induce the desired
therapeutic response ✔Correct Answer-E
Clearance Volume of a drug:
A. Indicated whether the drug is preferentially distributed to the brain and spinal cord
B. Is a measured quantity
C. Indicates whether the drug is preferentially distributed to different body compartments
D. Is the volume of blood from which a drug is completely removed in a set time (usually 1
minute) ✔Correct Answer-D
Two compartments filled with aqueous (water based) solution are separated by a lipid
membrane. In one compartment, the pH is 6; in the other compartment, the pH is 7. A weak
acid drug, pKa 5, is added to one compartment and sufficient time is allowed for equilibrium to
be achieved. At equilibrium:
A. The total concentration of ionized and non ionized drug is the same in both compartments
B. The total concentration of ionized and non ionized drug is greater in the more acidic
compartment
C. The concentration of non ionized drug is the same in both compartments and the total
concentration of ionized and non ionized drug is greater in the more basic compartment
D. The total concentration of ionized and non ionized drug is greater in the more basic
compartment
E. The concentration of non ionized drug is the same in both compartments ✔Correct
Answer-C
The affinity of a drug:
A. Will be predictive of the (agonist) potency of the drug if it is established that the drug is a full
agonist at those receptors.
B. Is the same for all types of receptor.
C. Is a measure of the clinical safety of the drug.
D. Predicts whether the drug will be agonist or antagonist at a particular type of receptor.
✔Correct Answer-A
Drug A has a t1/2 value which is twice the t1/2 value of Drug B. In comparing the use of these
drugs, it is likely that Drug A:
A. Is more likely than Drug B to cause adverse side effects.
B. Will be given more frequently than Drug B (to achieve the same steady state plasma
concentration).
C. Will be given less frequently than Drug B (to achieve the same steady state plasma
concentration).
D. Is more toxic than Drug B and will be given less frequently than Drug B (to achieve the same
steady state plasma concentration).
E. None of the above ✔Correct Answer-C
100% VERIFIED ANSWERS |LATEST VERSION |ALREADY
GRADED A+
If the volume of distribution of a drug is calculated to be the same as plasma volume, then one
should conclude that:
A. The drug has been eliminated before plasma drug concentration was measured.
B. The drug did not leave the systemic circulation.
C. The drug is present in the blood and the extracellular extravascular space but is absent from
the intracellular space.
D. The drug is sequestered to cells of a single organ or to a specific organelle within cells.
E. None of the above ✔Correct Answer-B
The Therapeutic Range of a drug:
A. Is the range of plasma concentration of the drug in which the drug produces the desired
therapeutic without producing any toxic effects or adverse side effects also produced.
B. Can only be determined for antagonist drugs.
C. Can only be determined for agonist drugs.
D. Is the range of plasma concentration of the drug in which the drug produces the desired
therapeutic effect regardless of any toxic effects or adverse side effects also produced
✔Correct Answer-A
The bioavailability of a drug administered orally (and swallowed!!!) is 0.9. Given this
information, you conclude that for an orally administered dose of this drug:
A. This drug is rapidly eliminated.
B. This drug is slowly eliminated.
C. Most of an orally administered dose of this drug is absorbed into the blood.
D. This drug will likely have insignificant therapeutic benefits if those benefits require the drug
to enter the systemic ✔Correct Answer-C
The Kd for a drug is:
A. Defined as the concentration of drug necessary to product 50% of the maximum response
when receptors are activated
B. Defined as the concentration of drug at which 50% of the receptors in a given population will
each be bound by a molecule of the drug (with the remaining receptors being unoccupied by
drug)
C. Defined as the concentration of drug required to inhibit an agonist response by 50%
assuming sufficient agonist s present to produce a response that is 100% of the maximum
response
D. Defined as the concentration of drug necessary to inhibit agonist binding by 50% assuming
sufficient agonist is present to bind to 100% of the receptors ✔Correct Answer-B
,You are given the same oral dose of a drug every 24 hours. By the sixth day, the drug seems to
have a reduced effectiveness (compared to its effect on the first couple of days). This reduced
effectiveness could be the result of:
A. Increased rate of delivery of the drug from the plasma to its sites of action and increased
affinity of the drug for the receptors through which the response is induced.
B. Increased affinity of the drug for the receptors through which the response is induced.
C. Increased rate of delivery of the drug from the plasma to its sites of action.
D. Decreased absorption of drug from the gastrointestinal tract.
E. Decreased rate of elimination ✔Correct Answer-D
The liver enzyme Enzyme Z metabolizes Drug A. If Drug A is administered repeatedly, then the
amount of Enzyme Z in the liver is increased. Consequently....
A. The rate of metabolism of Drug A will not change.
B. The rate of metabolism of any drug metabolized by Enzyme Z is decreased.
C. The half-life of all drugs metabolized by Enzyme Z will be decreased
D. The half-life of Drug A will be increased.
E. The half-life of Drug B, also metabolized by Enzyme Z, will not be affected ✔Correct
Answer-C
When a drug is dissolved in an aqueous (water-based) solution, the concentration of ionized
form of the drug is dependent on:
A. The acidity (pH) of the aqueous solution.
B. The lipid solubility of the drug.
C. The pKa of the drug.
D. The amount of drug dissolved in the solution.
E. The acidity (pH) of the aqueous solution, and the pKa of the drug, and the amount of the
drug dissolved in the solution ✔Correct Answer-E
Drug A is administered repeatedly with a constant interval between consecutive doses and with
a constant dose. The mean plasma concentration of Drug A is measured. The concentration:
A. Is independent on the route of administration but is dependent on the dose and the interval
between consecutive doses.
B. Is independent of the clearance volume for the drug.
C. Is independent of the route of administration
D. Is independent of the dose of drug administered but not of the interval between consecutive
doses
E. Is dependent on the dose and the interval between consecutive doses ✔Correct Answer-E
The therapeutic threshold concentration (aka minimal effective concentration) of a drug:
A. Determines the pharmacological and clinical (or physiological) efficacies of the drug.
B. Is affected by the ability of the body to eliminate (metabolize and/or excrete) the drug and
depends on the rate of absorption of the drug.
C. Depends on the rate of absorption of the drug.
, D. Is affected by the ability of the body to eliminate (metabolize and/or excrete) the drug.
E. Is the minimum plasma concentration of the drug which is required to induce the desired
therapeutic response ✔Correct Answer-E
Clearance Volume of a drug:
A. Indicated whether the drug is preferentially distributed to the brain and spinal cord
B. Is a measured quantity
C. Indicates whether the drug is preferentially distributed to different body compartments
D. Is the volume of blood from which a drug is completely removed in a set time (usually 1
minute) ✔Correct Answer-D
Two compartments filled with aqueous (water based) solution are separated by a lipid
membrane. In one compartment, the pH is 6; in the other compartment, the pH is 7. A weak
acid drug, pKa 5, is added to one compartment and sufficient time is allowed for equilibrium to
be achieved. At equilibrium:
A. The total concentration of ionized and non ionized drug is the same in both compartments
B. The total concentration of ionized and non ionized drug is greater in the more acidic
compartment
C. The concentration of non ionized drug is the same in both compartments and the total
concentration of ionized and non ionized drug is greater in the more basic compartment
D. The total concentration of ionized and non ionized drug is greater in the more basic
compartment
E. The concentration of non ionized drug is the same in both compartments ✔Correct
Answer-C
The affinity of a drug:
A. Will be predictive of the (agonist) potency of the drug if it is established that the drug is a full
agonist at those receptors.
B. Is the same for all types of receptor.
C. Is a measure of the clinical safety of the drug.
D. Predicts whether the drug will be agonist or antagonist at a particular type of receptor.
✔Correct Answer-A
Drug A has a t1/2 value which is twice the t1/2 value of Drug B. In comparing the use of these
drugs, it is likely that Drug A:
A. Is more likely than Drug B to cause adverse side effects.
B. Will be given more frequently than Drug B (to achieve the same steady state plasma
concentration).
C. Will be given less frequently than Drug B (to achieve the same steady state plasma
concentration).
D. Is more toxic than Drug B and will be given less frequently than Drug B (to achieve the same
steady state plasma concentration).
E. None of the above ✔Correct Answer-C
