PHM FINAL EXAM WITH ALL CORRECT & 100% VERIFIED ANSWERS |
LATEST VERSION |ALREADY GRADED A+
1. mtx
antidote = LEUCOVORIN*
(methotrex-
(MTX needs Leu)
ate)
AD= Crystalluria, bad for kidneys
-Anti-metabolite
-treat leukemia
-s-phase specific
-5dump, inhibits thymidine synthase
2. 5-FLU (Fluo-
rouracil) -Anti-metabolite
-treat leukemia
-s-phase specific
3. Bleomycin anti-tumor antibiotic
-cell specific
-ad = bleomycin lung, bad for pulmonary and hyper pigmentation
-g2 phase target
4. Doxorubicin anti-tumor antibiotic
-ad = cardio-toxic
-inhibit dan repair and stimulate free radicals
-non specific
-iv, turn veins red
5. anti-tumor -bleomycin (G2, break strands, bleomycin lung)
an-tibiotics -doxrubicin (unwind/break, free radicals, red veins, cardio-toxic)
6. Anti-metabolites -mtx (crystalluria, Leukemia, leucovorin antidote, s-phase)
-5-fu (inhibit thymidine, leukemia, s-phase)
7. Alkylating agents -Ifosfamide & cyclophosamide (bladder toxic)
1/
34
,PHM FINAL EXAM WITH ALL CORRECT & 100% VERIFIED ANSWERS |
LATEST VERSION |ALREADY GRADED A+
-bulsalfan (pulmonary issue_
2/
34
, PHM FINAL EXAM WITH ALL CORRECT & 100% VERIFIED ANSWERS |
LATEST VERSION |ALREADY GRADED A+
-nitrosoureas: Carmustine & Lomustine (most toxic)
-Dacarpazine (DTIC dome, Hodgkins)
*cause DNA alteration due to alkylation, more aggressive since its non-
specific, cause 2nd tumors and malignancy
-cross BBB
8. Ifosfamide & *ad = bladder toxicity
cy-
clophosamide Alkylating agents
-mutagenic, non-specific, alter dna
(ifosfamide is IV Verison, cyclopgasmide is oral route)
9. bulsalfan ad= *Bulsalfan lung, bad for lung
-alkylating agent, alter DNA
-treat myles. leukemia
10. nitrosoureas: most TOXIC alkylating agent,
Carmustine & Lo- ad= *CNS toxicity, Hepatic-toxicity, pulmonary toxicity,
mustine
-inhibit dna replication, dna cross links
-treat = brain tumors
11. Dacarpazine *DTIC dome, requires bio-activation to methylate DNA
-cause infertility
-treat Hodgkins lymphoma
12. Steroidal -Tamoxifen (1st line SERM)
Hor-mones -Prednisone (Anti-inflam, hypergly,immunosup)
-Raloxifene (SERM, better for bones)
-Fulverstrant (estrogen inhibitor injection)
13. Tamoxifen
3/
34
, PHM FINAL EXAM WITH ALL CORRECT & 100% VERIFIED ANSWERS |
LATEST VERSION |ALREADY GRADED A+
-1st line of therapy for breast cancer
-SERM, block estrogen activity
-AD = postmenopausal symptoms and hyperCa+
14. Prednisone -anti-inflammatory
-ad= Hyperglycemia, immunosupr., infections
15. Raloxifene SERM, like tamoxifen, but allows more estrogen activity in uterine/breast,
prevent bone reabsorption
ad= hot flashes and myalgias
16. Fulverstant -IM Injection
-Estrogen inhibitor
-down regulation for tumors: Breast cancer
17. Aromatase -Anastrozole & Letrozole
In-hibitors -Exemestane
(remember aromatase = androgen -> estrogen)
18. Anastrozole -Aromatase Inhibitors
& Letrozole -blocks Aromatase. the only enzyme that can create Estrogen in
Post-Menopausal women
*does not cause secondary tumors
19. Exemastane Irreversible aromatase inhibitor
-block androgen -> estrogen
20. GNRH Goserelin)
Analog
(Leuoprolid
e,
4/
34
LATEST VERSION |ALREADY GRADED A+
1. mtx
antidote = LEUCOVORIN*
(methotrex-
(MTX needs Leu)
ate)
AD= Crystalluria, bad for kidneys
-Anti-metabolite
-treat leukemia
-s-phase specific
-5dump, inhibits thymidine synthase
2. 5-FLU (Fluo-
rouracil) -Anti-metabolite
-treat leukemia
-s-phase specific
3. Bleomycin anti-tumor antibiotic
-cell specific
-ad = bleomycin lung, bad for pulmonary and hyper pigmentation
-g2 phase target
4. Doxorubicin anti-tumor antibiotic
-ad = cardio-toxic
-inhibit dan repair and stimulate free radicals
-non specific
-iv, turn veins red
5. anti-tumor -bleomycin (G2, break strands, bleomycin lung)
an-tibiotics -doxrubicin (unwind/break, free radicals, red veins, cardio-toxic)
6. Anti-metabolites -mtx (crystalluria, Leukemia, leucovorin antidote, s-phase)
-5-fu (inhibit thymidine, leukemia, s-phase)
7. Alkylating agents -Ifosfamide & cyclophosamide (bladder toxic)
1/
34
,PHM FINAL EXAM WITH ALL CORRECT & 100% VERIFIED ANSWERS |
LATEST VERSION |ALREADY GRADED A+
-bulsalfan (pulmonary issue_
2/
34
, PHM FINAL EXAM WITH ALL CORRECT & 100% VERIFIED ANSWERS |
LATEST VERSION |ALREADY GRADED A+
-nitrosoureas: Carmustine & Lomustine (most toxic)
-Dacarpazine (DTIC dome, Hodgkins)
*cause DNA alteration due to alkylation, more aggressive since its non-
specific, cause 2nd tumors and malignancy
-cross BBB
8. Ifosfamide & *ad = bladder toxicity
cy-
clophosamide Alkylating agents
-mutagenic, non-specific, alter dna
(ifosfamide is IV Verison, cyclopgasmide is oral route)
9. bulsalfan ad= *Bulsalfan lung, bad for lung
-alkylating agent, alter DNA
-treat myles. leukemia
10. nitrosoureas: most TOXIC alkylating agent,
Carmustine & Lo- ad= *CNS toxicity, Hepatic-toxicity, pulmonary toxicity,
mustine
-inhibit dna replication, dna cross links
-treat = brain tumors
11. Dacarpazine *DTIC dome, requires bio-activation to methylate DNA
-cause infertility
-treat Hodgkins lymphoma
12. Steroidal -Tamoxifen (1st line SERM)
Hor-mones -Prednisone (Anti-inflam, hypergly,immunosup)
-Raloxifene (SERM, better for bones)
-Fulverstrant (estrogen inhibitor injection)
13. Tamoxifen
3/
34
, PHM FINAL EXAM WITH ALL CORRECT & 100% VERIFIED ANSWERS |
LATEST VERSION |ALREADY GRADED A+
-1st line of therapy for breast cancer
-SERM, block estrogen activity
-AD = postmenopausal symptoms and hyperCa+
14. Prednisone -anti-inflammatory
-ad= Hyperglycemia, immunosupr., infections
15. Raloxifene SERM, like tamoxifen, but allows more estrogen activity in uterine/breast,
prevent bone reabsorption
ad= hot flashes and myalgias
16. Fulverstant -IM Injection
-Estrogen inhibitor
-down regulation for tumors: Breast cancer
17. Aromatase -Anastrozole & Letrozole
In-hibitors -Exemestane
(remember aromatase = androgen -> estrogen)
18. Anastrozole -Aromatase Inhibitors
& Letrozole -blocks Aromatase. the only enzyme that can create Estrogen in
Post-Menopausal women
*does not cause secondary tumors
19. Exemastane Irreversible aromatase inhibitor
-block androgen -> estrogen
20. GNRH Goserelin)
Analog
(Leuoprolid
e,
4/
34
