NR 566 Advanced Pharmacology
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
for the care of the family week 1 ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
antifungal agents exam with ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
correct answers ||\\||\\
Amphotericin B is a _________ antibiotic ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
is it well absorbed in the GI tract?
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
polyene
no; poorly absorbed. PO therapy won't work. must be
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
given IV! ||\\||\\
undergoes binding to sterol-containing membranes of ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
tissues
Amphotericin B must be given __ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
IV
Amphotericin B should be used in _______ ___________ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
________
_________ impairment occurs in all pts ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
,life threatening infections
||\\||\\ ||\\||\\
Renal
when it comes to ____________ _, kidney damage = total ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
dose in tx ||\\||\\ ||\\||\\
amphotericin B ||\\||\\
highly nephrotoxic ||\\||\\
if Amphotericin B dose > _ g, permanent damage is likely
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
to occur, can be decreased by infusing 1 L of saline
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
4
if plasma creatinine is > ____, decrease dose
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
3.5
high levels of Itraconazole can cause fatal __________
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
____________
if taking ____________ and ____________: monitor
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
levels!
ventricular dysrhythmias ||\\||\\
digoxin, cyclosporine ||\\||\\
, if taking Itraconazole with __________: PT time should be
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
monitored! can be _______ by azoles ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
if taking Itraconazole with _____________: check blood
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
sugar can be ________ by azoles, causing severe
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
hypoglocemia
warfarin; increased ||\\||\\
sulfonylureas; increased ||\\||\\
itraconazole is a ______ spectrum ____________ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
Azoles are often used as alternatives to _____________ _
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
for most systemic fungal infections, systemic and
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
superficial mycoses ||\\||\\
broad
antifungal
Amphotericin B ||\\||\\
old people have higher risk for ___________, decreasing
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
ability to absorb antifungal meds. ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
achlorhydria (no gastric acid in stomach) ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
Do not take Itraconazole with meds that raise gastric pH:
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
__________, __ ________, ____ ||\\||\\ ||\\||\\ ||\\||\\
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
for the care of the family week 1 ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
antifungal agents exam with ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
correct answers ||\\||\\
Amphotericin B is a _________ antibiotic ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
is it well absorbed in the GI tract?
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
polyene
no; poorly absorbed. PO therapy won't work. must be
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
given IV! ||\\||\\
undergoes binding to sterol-containing membranes of ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
tissues
Amphotericin B must be given __ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
IV
Amphotericin B should be used in _______ ___________ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
________
_________ impairment occurs in all pts ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
,life threatening infections
||\\||\\ ||\\||\\
Renal
when it comes to ____________ _, kidney damage = total ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
dose in tx ||\\||\\ ||\\||\\
amphotericin B ||\\||\\
highly nephrotoxic ||\\||\\
if Amphotericin B dose > _ g, permanent damage is likely
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
to occur, can be decreased by infusing 1 L of saline
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
4
if plasma creatinine is > ____, decrease dose
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
3.5
high levels of Itraconazole can cause fatal __________
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
____________
if taking ____________ and ____________: monitor
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
levels!
ventricular dysrhythmias ||\\||\\
digoxin, cyclosporine ||\\||\\
, if taking Itraconazole with __________: PT time should be
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
monitored! can be _______ by azoles ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
if taking Itraconazole with _____________: check blood
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
sugar can be ________ by azoles, causing severe
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
hypoglocemia
warfarin; increased ||\\||\\
sulfonylureas; increased ||\\||\\
itraconazole is a ______ spectrum ____________ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
Azoles are often used as alternatives to _____________ _
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
for most systemic fungal infections, systemic and
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
superficial mycoses ||\\||\\
broad
antifungal
Amphotericin B ||\\||\\
old people have higher risk for ___________, decreasing
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
ability to absorb antifungal meds. ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
achlorhydria (no gastric acid in stomach) ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
Do not take Itraconazole with meds that raise gastric pH:
||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\ ||\\||\\
__________, __ ________, ____ ||\\||\\ ||\\||\\ ||\\||\\
