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Lecture notes Medical Genetics (MM108)

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This lecture covers the fundamental concepts of gene expression, tracking how genetic information flows from DNA to functional products, primarily proteins.

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,Types of RNA
} mRNA
Ø Carries information from DNA to the ribosome
Ø The coding sequence of mRNA determines the
amino acids sequence in the protein that is
produced

} tRNA
Ø Transfers a specific amino acid to a growing
polypeptide chain at the ribosome
Ø It has sites for amino acid attachment and a codon
recognition site that binds to a specific sequence on
the mRNA
3

,Types of RNA
} rRNA
Ø rRNA and protein combine in the
cytoplasm to form ribosome
Ø Is the catalytic component of
ribosomes
Ø Eukaryotic ribosomes contain 4
different rRNA molecules: 18S, 5.8S,
28S, 5S
Ø Ribosome binds to mRNA and
carries out protein synthesis



4

, Telomere shortening



} Because of the 5’-3’ direction
of the DNA polymerase, the
lagging strand cannot be
replicated to the end
Ø This will results in
Telomere shortening

} If the telomeres become too
short, the cell will undergo
apoptosis

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