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1. heparin anticoagulant, indirect thrombin inhibitor
2. heparin actions prolong coagulation time, prevent
excessive clotting with blood vessels, CAN'T DISSOLVE CLOTS
3. heparin admin use dose with appropriate weight, aPTT
value, clinical indication do not massage site no IM injection
4. heparin adverse ef- abnormal bleeding, heparin-induced
thrombocytopenia, may experience fects life-threatening thrombosis
5. heparin black box epidural/spinal hematomas could occur,
permanent paralysis
, 6. heparin con- active internal bleeding, bleeding disorders,
severe hypertension, recent trautraindications ma, intracranial
hemorrhage or bacterial endocarditis
7. heparin drug-drug warfarin, aspirin, indomethacin, ibuprofen,
nicotine, digoxin, tetracyclines, antihistamines
8. heparin herbal ginger, garlic, green tea, feverfew, gingko
9. heparin tx of over- protamine sulfate IV dose
10. warfarin anticoagulant, vitamin K antagonist
11. warfarin action prevention of stroke, MI, DVT, pulmonary
embolism when in hip/knee surgery, given to prevent
thromboembolic events, can take several days to reach maximum
effect
1-10mcg/mL
, 1. warfarin admin effects can be reduced by IM or
subcutaneous
2. abnormal bleeding, stays in system up to 10 days
warfarin adverse effects
3. warfarin black box fatal bleeding, regular monitoring of INR
4. warfarin con- recent trauma, active internal bleeding,
bleeding disorders, intracranial hemtraindications orrhage, severe
HTN, bacterial endocarditis, liver or kidney disease
5. warfarin alcohol, NSAIDs, SSRI, antidepressants, steroids,
antibiotics, vaccines, vitamins drug-drug
6. warfarin herbal green tea, gingko, feverfew, garlic,
cranberry, chamomile, ginger, foods rich in vitamin K