TEST BANK PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE NURSE 4TH EDITION TERI
MOSER WOO (CHAPTER 1-52) QUESTIONS AND
CORRECT ANSWERS (VERIFIED ANSWERS) Q&A
2026 |INSTANT DOWNLOAD PDF
1. Pharmacokinetics: Absorption
Which factor most significantly increases oral drug absorption
in the small intestine?
A. Low blood flow to the gut
B. Increased surface area of villi
C. Presence of food in the stomach
D. Reduced gastric pH
Rationale: The small intestine has villi and microvilli that greatly
increase surface area, enhancing drug absorption.
Correct answer: B. Increased surface area of villi
2. Drug Metabolism
Which organ is primarily responsible for Phase I drug
metabolism?
A. Kidney
B. Liver
,C. Pancreas
D. Lung
Rationale: The liver contains cytochrome P450 enzymes
responsible for most Phase I reactions.
Correct answer: B. Liver
3. Adverse Drug Reactions
A predictable, dose-dependent adverse drug reaction is
classified as:
A. Type B reaction
B. Idiosyncratic reaction
C. Type A reaction
D. Allergic reaction
Rationale: Type A reactions are predictable and related to drug
dose.
Correct answer: C. Type A reaction
4. Antibiotic Mechanisms
Penicillins exert their antibacterial effect by:
A. Inhibiting protein synthesis
B. Disrupting DNA replication
C. Inhibiting cell wall synthesis
D. Blocking folic acid metabolism
,Rationale: Penicillins inhibit bacterial cell wall synthesis by
binding to PBPs.
Correct answer: C. Inhibiting cell wall synthesis
5. Antihypertensive Therapy
Which drug class is first-line for uncomplicated hypertension
in most guidelines?
A. Beta-blockers
B. ACE inhibitors
C. Loop diuretics
D. Vasodilators
Rationale: ACE inhibitors are commonly recommended first-line
due to renal and cardiovascular benefits.
Correct answer: B. ACE inhibitors
6. Drug Interactions
Warfarin interacts most significantly with drugs that:
A. Increase vitamin K intake
B. Induce or inhibit CYP450 enzymes
C. Reduce gastric acid secretion
D. Increase renal clearance
Rationale: CYP450 interactions alter warfarin metabolism and
INR levels.
Correct answer: B. Induce or inhibit CYP450 enzymes
, 7. Diabetes Management
Which medication increases insulin sensitivity in type 2
diabetes?
A. Metformin
B. Glipizide
C. Insulin glargine
D. Acarbose
Rationale: Metformin improves peripheral insulin sensitivity
and reduces hepatic glucose production.
Correct answer: A. Metformin
8. Pharmacodynamics
The term "efficacy" refers to a drug’s:
A. Safety profile
B. Maximum effect achievable
C. Absorption rate
D. Half-life
Rationale: Efficacy is the maximum response a drug can
produce.
Correct answer: B. Maximum effect achievable
9. Opioid Effects
ADVANCED PRACTICE NURSE 4TH EDITION TERI
MOSER WOO (CHAPTER 1-52) QUESTIONS AND
CORRECT ANSWERS (VERIFIED ANSWERS) Q&A
2026 |INSTANT DOWNLOAD PDF
1. Pharmacokinetics: Absorption
Which factor most significantly increases oral drug absorption
in the small intestine?
A. Low blood flow to the gut
B. Increased surface area of villi
C. Presence of food in the stomach
D. Reduced gastric pH
Rationale: The small intestine has villi and microvilli that greatly
increase surface area, enhancing drug absorption.
Correct answer: B. Increased surface area of villi
2. Drug Metabolism
Which organ is primarily responsible for Phase I drug
metabolism?
A. Kidney
B. Liver
,C. Pancreas
D. Lung
Rationale: The liver contains cytochrome P450 enzymes
responsible for most Phase I reactions.
Correct answer: B. Liver
3. Adverse Drug Reactions
A predictable, dose-dependent adverse drug reaction is
classified as:
A. Type B reaction
B. Idiosyncratic reaction
C. Type A reaction
D. Allergic reaction
Rationale: Type A reactions are predictable and related to drug
dose.
Correct answer: C. Type A reaction
4. Antibiotic Mechanisms
Penicillins exert their antibacterial effect by:
A. Inhibiting protein synthesis
B. Disrupting DNA replication
C. Inhibiting cell wall synthesis
D. Blocking folic acid metabolism
,Rationale: Penicillins inhibit bacterial cell wall synthesis by
binding to PBPs.
Correct answer: C. Inhibiting cell wall synthesis
5. Antihypertensive Therapy
Which drug class is first-line for uncomplicated hypertension
in most guidelines?
A. Beta-blockers
B. ACE inhibitors
C. Loop diuretics
D. Vasodilators
Rationale: ACE inhibitors are commonly recommended first-line
due to renal and cardiovascular benefits.
Correct answer: B. ACE inhibitors
6. Drug Interactions
Warfarin interacts most significantly with drugs that:
A. Increase vitamin K intake
B. Induce or inhibit CYP450 enzymes
C. Reduce gastric acid secretion
D. Increase renal clearance
Rationale: CYP450 interactions alter warfarin metabolism and
INR levels.
Correct answer: B. Induce or inhibit CYP450 enzymes
, 7. Diabetes Management
Which medication increases insulin sensitivity in type 2
diabetes?
A. Metformin
B. Glipizide
C. Insulin glargine
D. Acarbose
Rationale: Metformin improves peripheral insulin sensitivity
and reduces hepatic glucose production.
Correct answer: A. Metformin
8. Pharmacodynamics
The term "efficacy" refers to a drug’s:
A. Safety profile
B. Maximum effect achievable
C. Absorption rate
D. Half-life
Rationale: Efficacy is the maximum response a drug can
produce.
Correct answer: B. Maximum effect achievable
9. Opioid Effects
