NR 565 - advanced pharmacology midterm -
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Terms in this set (244)
During what trimester is a pregnant 1st trimester (fetus most at risk d/t rapid growth)
woman most at risk for adverse drug
reactions with potential long term
consequences?
What is BEERS criteria? Recommendations of medications inappropriate for
elderly (65 and older), prescriber ultimately
decides
What is the CYP450 (cytochrome liver enzyme system where medications are
P450) metabolized, can either be inducers or inhibitors
and create drug-drug interactions
CYP450 inducers Speed up metabolism of drugs (drug is cleared
faster), drug has lesser effect (decrease blood
levels of drug), elevate CYP450 enzymes
CYP450 inducers pneumonic "Bullshit Crap GPS INDUCES rage"
,CYP450 inducer drug names Barbituates, St John wort, Carbamazepine, rifampin,
alcohol, phenytoin, griseofulvin, phenobarbital,
sulfonylureas
CYP450 inhibitors inhibit metabolism, increase blood levels of
medications
CYP450 pneumonic "VISA credit card debt INHIBITS spending on
designers like CK to look GQ"
CYP450 inhibitors drug names Valproate, isoniazid, sulfonamides, amiodarone,
chloramphenicol, ketoconazole, grapefruit juice,
quinidine
Physiological changes during increase glomerular filtration rate leads to increase
pregnancy that impact durg excretion
pharmacodynamics and increase hepatic metabolism
pharmacokinetic properties of decrease tone and motility of bowel
drugs? increase drug absorption
Examples of medications that can be Antiepileptic drugs, antimicrobials such as
teratogenic tetracyclines and fluoroquinolones, vitamin A in
large doses, some anticoagulants, and hormonal
medications such as diethylstilbestrol (DES).
How is absorption of intramuscular slow and erratic due to low blood flow in muscles
medications different in neonates? first few days of life
Why is absorption of medication in delayed gastric emptying
the stomach increased in infancy?
, Some medications that should be glucocorticoids, discoloration of developing teeth
avoided in the pediatric patient? with tetracyclines, and kernicterus with
sulfonamides, levofloxacin (antibiotics)
aspirin (Severe intoxication from acute overdose)
what should be included in dosage size and timing
medication administration patient route and technique of administration
education? duration of treatment
drug storage
nature and time course of desired responses
nature and time course of adverse responses
finish taking antibiotic
What are some things that put the reduced renal function
elderly patient at higher risk for polypharmacy (the use of five or more medications
adverse drug reactions? daily)
greater severity of illness
presence of comorbidities
use of drugs that have a low therapeutic index (e.g.,
digoxin)
increased individual variation secondary to altered
pharmacokinetics
inadequate supervision of long-term therapy
poor patient adherence
Chamberlain | questions and Answers | LATEST
UPDATE
Save
Terms in this set (244)
During what trimester is a pregnant 1st trimester (fetus most at risk d/t rapid growth)
woman most at risk for adverse drug
reactions with potential long term
consequences?
What is BEERS criteria? Recommendations of medications inappropriate for
elderly (65 and older), prescriber ultimately
decides
What is the CYP450 (cytochrome liver enzyme system where medications are
P450) metabolized, can either be inducers or inhibitors
and create drug-drug interactions
CYP450 inducers Speed up metabolism of drugs (drug is cleared
faster), drug has lesser effect (decrease blood
levels of drug), elevate CYP450 enzymes
CYP450 inducers pneumonic "Bullshit Crap GPS INDUCES rage"
,CYP450 inducer drug names Barbituates, St John wort, Carbamazepine, rifampin,
alcohol, phenytoin, griseofulvin, phenobarbital,
sulfonylureas
CYP450 inhibitors inhibit metabolism, increase blood levels of
medications
CYP450 pneumonic "VISA credit card debt INHIBITS spending on
designers like CK to look GQ"
CYP450 inhibitors drug names Valproate, isoniazid, sulfonamides, amiodarone,
chloramphenicol, ketoconazole, grapefruit juice,
quinidine
Physiological changes during increase glomerular filtration rate leads to increase
pregnancy that impact durg excretion
pharmacodynamics and increase hepatic metabolism
pharmacokinetic properties of decrease tone and motility of bowel
drugs? increase drug absorption
Examples of medications that can be Antiepileptic drugs, antimicrobials such as
teratogenic tetracyclines and fluoroquinolones, vitamin A in
large doses, some anticoagulants, and hormonal
medications such as diethylstilbestrol (DES).
How is absorption of intramuscular slow and erratic due to low blood flow in muscles
medications different in neonates? first few days of life
Why is absorption of medication in delayed gastric emptying
the stomach increased in infancy?
, Some medications that should be glucocorticoids, discoloration of developing teeth
avoided in the pediatric patient? with tetracyclines, and kernicterus with
sulfonamides, levofloxacin (antibiotics)
aspirin (Severe intoxication from acute overdose)
what should be included in dosage size and timing
medication administration patient route and technique of administration
education? duration of treatment
drug storage
nature and time course of desired responses
nature and time course of adverse responses
finish taking antibiotic
What are some things that put the reduced renal function
elderly patient at higher risk for polypharmacy (the use of five or more medications
adverse drug reactions? daily)
greater severity of illness
presence of comorbidities
use of drugs that have a low therapeutic index (e.g.,
digoxin)
increased individual variation secondary to altered
pharmacokinetics
inadequate supervision of long-term therapy
poor patient adherence
