WGU D027 Advanced Pathopharmacological Foundations
Mock Exam 2026 | Trusted Questions & Answers
1. Kallie is a 35-year-old female who complains of widespread musculoskeletal
pain and fatigue for the last year. After ruling out other possible diagnoses,
she is diagnosed with fibromyalgia. You are educating her on her diagnosis.
Which information is correct teaching for fibromyalgia?
She will need to have her ANA level checked every three months to
predict exacerbations
She should avoid sulfa antibiotics going forward to prevent
exacerbations
Opioid medications are first-line treatment for pain control
Adequate sleep and exercise are often first-line treatment
2. A patient presents with symptoms of fatigue, weight gain, and constipation.
Which diagnostic tests would be most appropriate to confirm a suspicion of
hypothyroidism?
Measuring blood glucose levels and lipid profile.
Testing for anti-TPO and anti-Tg antibodies along with TSH levels.
Assessing vitamin D levels and calcium levels.
Performing a complete blood count and liver function tests.
3. What does an ejection fraction of 42% indicate in a patient with heart failure?
Severe arrhythmia
Increased cardiac output
Reduced cardiac function
, Normal cardiac function
4. What is the primary medication that should not be taken with red yeast rice
due to potential interactions?
Lisinopril (Zestril)
Lovastatin (Mevacor)
Ibuprofen (Motrin)
Sildenafil (Viagra)
5. What is the probability that future children of parents, one of whom is a
carrier of alpha thalassemia, will inherit the condition if their current child has
it?
50%
100%
0%
25%
6. Which of the following is the most appropriate recommendation for initial
lipid lowering therapy to lower his ASCVD risk?
Fenofibrate 135 mg daily
Rosuvastatin 20 mg
Atorvastatin 10 mg
Ezetimibe 10 mg daily
7. Describe how hypothyroidism can lead to constipation as a clinical
manifestation.
Hypothyroidism has no effect on gastrointestinal function.
, Hypothyroidism causes diarrhea due to increased hormone levels.
Hypothyroidism slows down metabolism, which can lead to
decreased gastrointestinal motility and constipation.
Hypothyroidism increases metabolism, causing increased bowel
movements.
8. What medication should be stopped according to the 2017 heart failure
guidelines for a patient with systolic CHF?
Nifedipine (Procardia)
Lisinopril (Zestril)
Amlodipine (Norvasc)
Angiotensin receptor blockers (ARB)
9. A 60-year-old male patient with chronic pain is currently prescribed
morphine and duloxetine. If he develops increased pain and the physician
considers adding a new medication, which option should be avoided due to
potential interactions?
Acetaminophen (Tylenol)
Lidocaine patches (Lidoderm)
Naproxen (Aleve)
Tramadol (Ultram)
10. A 60-year-old patient presents with elevated blood pressure readings
during a routine check-up but claims to feel fine. How should a nurse
proceed to ensure an accurate diagnosis?
Advise the patient to monitor their blood pressure at home without
further assessment.
Mock Exam 2026 | Trusted Questions & Answers
1. Kallie is a 35-year-old female who complains of widespread musculoskeletal
pain and fatigue for the last year. After ruling out other possible diagnoses,
she is diagnosed with fibromyalgia. You are educating her on her diagnosis.
Which information is correct teaching for fibromyalgia?
She will need to have her ANA level checked every three months to
predict exacerbations
She should avoid sulfa antibiotics going forward to prevent
exacerbations
Opioid medications are first-line treatment for pain control
Adequate sleep and exercise are often first-line treatment
2. A patient presents with symptoms of fatigue, weight gain, and constipation.
Which diagnostic tests would be most appropriate to confirm a suspicion of
hypothyroidism?
Measuring blood glucose levels and lipid profile.
Testing for anti-TPO and anti-Tg antibodies along with TSH levels.
Assessing vitamin D levels and calcium levels.
Performing a complete blood count and liver function tests.
3. What does an ejection fraction of 42% indicate in a patient with heart failure?
Severe arrhythmia
Increased cardiac output
Reduced cardiac function
, Normal cardiac function
4. What is the primary medication that should not be taken with red yeast rice
due to potential interactions?
Lisinopril (Zestril)
Lovastatin (Mevacor)
Ibuprofen (Motrin)
Sildenafil (Viagra)
5. What is the probability that future children of parents, one of whom is a
carrier of alpha thalassemia, will inherit the condition if their current child has
it?
50%
100%
0%
25%
6. Which of the following is the most appropriate recommendation for initial
lipid lowering therapy to lower his ASCVD risk?
Fenofibrate 135 mg daily
Rosuvastatin 20 mg
Atorvastatin 10 mg
Ezetimibe 10 mg daily
7. Describe how hypothyroidism can lead to constipation as a clinical
manifestation.
Hypothyroidism has no effect on gastrointestinal function.
, Hypothyroidism causes diarrhea due to increased hormone levels.
Hypothyroidism slows down metabolism, which can lead to
decreased gastrointestinal motility and constipation.
Hypothyroidism increases metabolism, causing increased bowel
movements.
8. What medication should be stopped according to the 2017 heart failure
guidelines for a patient with systolic CHF?
Nifedipine (Procardia)
Lisinopril (Zestril)
Amlodipine (Norvasc)
Angiotensin receptor blockers (ARB)
9. A 60-year-old male patient with chronic pain is currently prescribed
morphine and duloxetine. If he develops increased pain and the physician
considers adding a new medication, which option should be avoided due to
potential interactions?
Acetaminophen (Tylenol)
Lidocaine patches (Lidoderm)
Naproxen (Aleve)
Tramadol (Ultram)
10. A 60-year-old patient presents with elevated blood pressure readings
during a routine check-up but claims to feel fine. How should a nurse
proceed to ensure an accurate diagnosis?
Advise the patient to monitor their blood pressure at home without
further assessment.
