AMERICAN ASSOCIATION OF NURSE PRACTITIONERS
(AANP) PRACTICE EXAMINATION 2026
Advanced Clinical Knowledge, Diagnosis, Pharmacology, and Primary
Care Decision-Making Assessment
Examination Level: Nurse Practitioner Certification Readiness
SPRING SEMESTER EXAM 2026
The most commonly prescribed medication for mild systemic lupus erythematosus (SLE) is:
1. azathioprine (AZA).
2. belimumab (Benlysta).
3. ibuprofen (Advil).
4. cyclophosphamide (Cytoxan).
ibuprofen (advil)
The most common sign of cervical cancer is:
1. postcoital bleeding.
2. strong odor from vaginal discharge.
3. itching in the vaginal area.
4. molluscum contagiosum.
1
postcoital bleeding
Page
1|Page
, The nurse practitioner prescribes amitriptyline (Elavil) for a patient with neuropathic pain
secondary to diabetes mellitus. On follow-up, the patient complains of urine retention and dry
mouth. The practitioner would:
1. discontinue amitriptyline and begin ibuprofen (Motrin).
2. refer to physical therapy.
3. start methocarbamol (Robaxin).
4. discontinue amitriptyline and begin gabapentin (Neurontin).
discontinue amitriptyline and begin gabapentin (neurontin)
A 17-year-old male with rheumatoid arthritis is being treated with an NSAID and omeprazole
(Prilosec). The patient complains of headache, abdominal pain, and gas. These symptoms are
most likely:
1. associated with the omeprazole.
2. related to the underlying condition.
3. the result of the NSAID.
4. caused by viral gastroenteritis.
associated with the omeprazole
The medication of choice for the initial treatment of juvenile rheumatoid arthritis is:
2
1. acetaminophen.
Page
2|Page
, 2. prednisone.
3. aspirin.
4. ibuprofen.
ibuprofen
A 12-year-old with sickle cell anemia has recently experienced a sickle cell crisis and presents for
a follow-up examination after a recent hospitalization. It is most important to continue
monitoring growth, development, and:
1. white blood cell levels.
2. fecal occult blood test.
3. hemoglobin levels.
4. urine dipsticks.
hemoglobin levels
A 90-year-old female is brought to the clinic by her neighbor. She states that everything is fine,
but the nurse practitioner notes that she has poor hygiene and bruises on her trunk. The
neighbor is concerned that the patient often has no money to buy food, despite income from
social security and a coal miner's pension. The nurse practitioner suspects abuse. Which of the
following is the nurse practitioner obligated to do next?
1. Report the case to the proper authorities.
2. Tell the neighbor to check on the woman daily and report back.
3. Document the data and report the information to risk management.
4. Call the patient's family and inquire about the concerns.
report the case to proper authorities
3
Page
3|Page
(AANP) PRACTICE EXAMINATION 2026
Advanced Clinical Knowledge, Diagnosis, Pharmacology, and Primary
Care Decision-Making Assessment
Examination Level: Nurse Practitioner Certification Readiness
SPRING SEMESTER EXAM 2026
The most commonly prescribed medication for mild systemic lupus erythematosus (SLE) is:
1. azathioprine (AZA).
2. belimumab (Benlysta).
3. ibuprofen (Advil).
4. cyclophosphamide (Cytoxan).
ibuprofen (advil)
The most common sign of cervical cancer is:
1. postcoital bleeding.
2. strong odor from vaginal discharge.
3. itching in the vaginal area.
4. molluscum contagiosum.
1
postcoital bleeding
Page
1|Page
, The nurse practitioner prescribes amitriptyline (Elavil) for a patient with neuropathic pain
secondary to diabetes mellitus. On follow-up, the patient complains of urine retention and dry
mouth. The practitioner would:
1. discontinue amitriptyline and begin ibuprofen (Motrin).
2. refer to physical therapy.
3. start methocarbamol (Robaxin).
4. discontinue amitriptyline and begin gabapentin (Neurontin).
discontinue amitriptyline and begin gabapentin (neurontin)
A 17-year-old male with rheumatoid arthritis is being treated with an NSAID and omeprazole
(Prilosec). The patient complains of headache, abdominal pain, and gas. These symptoms are
most likely:
1. associated with the omeprazole.
2. related to the underlying condition.
3. the result of the NSAID.
4. caused by viral gastroenteritis.
associated with the omeprazole
The medication of choice for the initial treatment of juvenile rheumatoid arthritis is:
2
1. acetaminophen.
Page
2|Page
, 2. prednisone.
3. aspirin.
4. ibuprofen.
ibuprofen
A 12-year-old with sickle cell anemia has recently experienced a sickle cell crisis and presents for
a follow-up examination after a recent hospitalization. It is most important to continue
monitoring growth, development, and:
1. white blood cell levels.
2. fecal occult blood test.
3. hemoglobin levels.
4. urine dipsticks.
hemoglobin levels
A 90-year-old female is brought to the clinic by her neighbor. She states that everything is fine,
but the nurse practitioner notes that she has poor hygiene and bruises on her trunk. The
neighbor is concerned that the patient often has no money to buy food, despite income from
social security and a coal miner's pension. The nurse practitioner suspects abuse. Which of the
following is the nurse practitioner obligated to do next?
1. Report the case to the proper authorities.
2. Tell the neighbor to check on the woman daily and report back.
3. Document the data and report the information to risk management.
4. Call the patient's family and inquire about the concerns.
report the case to proper authorities
3
Page
3|Page
