Comprehensive Basic Science Exam (CBSE) Review Set I
Latest Update 2026 | Exam Prep | High-Yield Study Guide
1. What are adverse drug reactions?
Intended effects of drugs on patients
Effects of drugs on the environment
Unintended effects of drugs on patients
Effects of drugs on animals
2. What is the mechanism of action of teniposide?
It acts as an antimetabolite to prevent DNA synthesis
It inhibits TOPO I and causes accumulation of DNA damage
It acts as an alkylating agent to cause alkylation of DNA
It inhibits TOPO II and causes accumulation of DNA damage
It acts as a DNA damaging agent to cause double strand DNA break
3. The function(s) of monocytes is to ___ _.
phagocytize pathogens, especially bacteria
attack abnormal body cells
phagocytize antigen-antibody complexes and allergens
coordinate immune responses
phagocytize pathogens, cellular debris, and dead cells
,4. An endocrine tumor syndrome that predisposes the patient to the
development of tumors of the parathyroid glands, anterior pituitary, and
pancreatic cells:
diabetes mellitus
MEN1
MEN2
metabolic syndrome
5. A patient is experiencing severe gastroesophageal reflux disease (GERD)
symptoms. Which medication would be most appropriate to prescribe for
reducing their stomach acid production?
Metoprolol
Diphenhydramine
Pantoprazole
Amoxicillin
6. Mutation of voltage-gated potassium channel. Autosomal dominant. No
hearing loss. Prolonged QT.
Brugada syndrome.
Jervell and Lange-Nielsen syndrome.
Romano-Ward syndrome.
7. What is the primary function of topoisomerase during DNA replication?
Unwind the DNA double helix
Relieve strain in the double helix ahead of the replication fork
Repair damaged DNA
, Synthesize new DNA strands
8. Which of the following is TRUE for scalded skin syndrome?
It is produced by Staphylococcus aureus
Large sections of skin exfoliate
It heals without scarring with antibiotic treatment
It may show a positive Nikolsky sign
All of the other answers are true
9. What is the primary viral infection that cidofovir is indicated for?
Herpes simplex virus infections
Hepatitis B virus infections
Influenza virus infections
HIV infections
10. In what way is Flexeril (cyclobenzaprine) somewhat unique among muscle
relaxants that affect the central nervous system?
Flexeril acts at the acetylcholine (Ach) receptors, producing
neuromuscular blockade.
Flexeril shares pharmacologic characteristics with the tricyclic
antidepressant agents.
Flexeril has more peripheral effect.
Flexeril is a GABA-agonist similar to barbiturates.
11. Zollinger-Ellison (Z-E) syndrome, hypersecretion of gastric HCl that causes
ulcers, is characterized by a great elevation of the level of the hormone:
, Gastrin
Cholecystokinin
Pepsin
Glucagon
12. If a patient presents with a severe herpes simplex virus infection and is not
responding to standard treatments, what role could cidofovir play in their
management?
Cidofovir would not be appropriate as it is only used for bacterial
infections.
Cidofovir could be used as an alternative antiviral treatment for the
herpes simplex virus infection.
Cidofovir would be used to treat fungal infections instead.
Cidofovir could be used to prevent future infections.
13. Describe the transmission method of Chagas disease and its implications for
public health.
Chagas disease is transmitted through the bite of triatomine bugs,
which poses a risk for public health in endemic areas.
Chagas disease is transmitted via respiratory droplets, similar to
influenza.
Chagas disease is spread through contaminated water, affecting
urban populations.
Chagas disease is spread through sexual contact, increasing its
prevalence among adults.
14. What is the MOA for Clomiphene to restore ovulation?
Latest Update 2026 | Exam Prep | High-Yield Study Guide
1. What are adverse drug reactions?
Intended effects of drugs on patients
Effects of drugs on the environment
Unintended effects of drugs on patients
Effects of drugs on animals
2. What is the mechanism of action of teniposide?
It acts as an antimetabolite to prevent DNA synthesis
It inhibits TOPO I and causes accumulation of DNA damage
It acts as an alkylating agent to cause alkylation of DNA
It inhibits TOPO II and causes accumulation of DNA damage
It acts as a DNA damaging agent to cause double strand DNA break
3. The function(s) of monocytes is to ___ _.
phagocytize pathogens, especially bacteria
attack abnormal body cells
phagocytize antigen-antibody complexes and allergens
coordinate immune responses
phagocytize pathogens, cellular debris, and dead cells
,4. An endocrine tumor syndrome that predisposes the patient to the
development of tumors of the parathyroid glands, anterior pituitary, and
pancreatic cells:
diabetes mellitus
MEN1
MEN2
metabolic syndrome
5. A patient is experiencing severe gastroesophageal reflux disease (GERD)
symptoms. Which medication would be most appropriate to prescribe for
reducing their stomach acid production?
Metoprolol
Diphenhydramine
Pantoprazole
Amoxicillin
6. Mutation of voltage-gated potassium channel. Autosomal dominant. No
hearing loss. Prolonged QT.
Brugada syndrome.
Jervell and Lange-Nielsen syndrome.
Romano-Ward syndrome.
7. What is the primary function of topoisomerase during DNA replication?
Unwind the DNA double helix
Relieve strain in the double helix ahead of the replication fork
Repair damaged DNA
, Synthesize new DNA strands
8. Which of the following is TRUE for scalded skin syndrome?
It is produced by Staphylococcus aureus
Large sections of skin exfoliate
It heals without scarring with antibiotic treatment
It may show a positive Nikolsky sign
All of the other answers are true
9. What is the primary viral infection that cidofovir is indicated for?
Herpes simplex virus infections
Hepatitis B virus infections
Influenza virus infections
HIV infections
10. In what way is Flexeril (cyclobenzaprine) somewhat unique among muscle
relaxants that affect the central nervous system?
Flexeril acts at the acetylcholine (Ach) receptors, producing
neuromuscular blockade.
Flexeril shares pharmacologic characteristics with the tricyclic
antidepressant agents.
Flexeril has more peripheral effect.
Flexeril is a GABA-agonist similar to barbiturates.
11. Zollinger-Ellison (Z-E) syndrome, hypersecretion of gastric HCl that causes
ulcers, is characterized by a great elevation of the level of the hormone:
, Gastrin
Cholecystokinin
Pepsin
Glucagon
12. If a patient presents with a severe herpes simplex virus infection and is not
responding to standard treatments, what role could cidofovir play in their
management?
Cidofovir would not be appropriate as it is only used for bacterial
infections.
Cidofovir could be used as an alternative antiviral treatment for the
herpes simplex virus infection.
Cidofovir would be used to treat fungal infections instead.
Cidofovir could be used to prevent future infections.
13. Describe the transmission method of Chagas disease and its implications for
public health.
Chagas disease is transmitted through the bite of triatomine bugs,
which poses a risk for public health in endemic areas.
Chagas disease is transmitted via respiratory droplets, similar to
influenza.
Chagas disease is spread through contaminated water, affecting
urban populations.
Chagas disease is spread through sexual contact, increasing its
prevalence among adults.
14. What is the MOA for Clomiphene to restore ovulation?
