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• Physicians Desk Reference (PDR) -✓✓Most common reference book in dental
office
• Harrison Narcotic Act -✓✓Regulations governing the use of opium, opiates, and
cocaine
• Trade name -✓✓Brand name, capitalized, many names
• Generic name -✓✓Lower cased, only one name
• Food and Drug Administration (FDA) -✓✓Determines what drugs may be sold
by Rx and OTC and regulates advertising of Rx drugs
• Federal Trade Commission (FTC) -✓✓Regulates the trade practices of drug
companies and prohibits false advertising
• Drug Enforcement Administration (DEA) -✓✓Dept of Justice; administers the
Controlled Substances Act of 1970; regulates manufacture and distribution of
substances that have potential for abuse including opioids, narcotics, stimulants,
and sedatives
• Omnibus Budget Reconciliation Act of 1990 (OBRA) -✓✓Mandates that by Jan.
1, 1993, pharmacists must provide patient counseling and a prospective drug
utilization review (DUR) for Medicaid patients; now must be for ALL patients
, • Potency -✓✓Function of amount of drug required to produce effect
• Efficacy -✓✓Maximum intensity effect or response that can be produced by a
drug
• Median Effective Dose (ED50) -✓✓Dose of drug required to produce specific
effect in 50% of subjects
• Median Lethal Dose (LD50) -✓✓Dose when 50% of subjects die
• Neurotransmitters -✓✓Chemicals responsible for transmitting a wide variety of
messages across a synapse
• Synapse -✓✓Space b/w nerve and receptor
• Fast/5/Ion Channel -✓✓Consists of 5 transmembrane regions; faster than G-
protein linked
• Slow/7/G-protein/2nd messenger -✓✓Consists of 7 transmembrane regions that
all use G-protein and 2nd messenger
• Ligand-bonding domain -✓✓Location where drug binds to receptor; key
• Lipophilic membrane-spanning segments -✓✓Opens path into cell membrane;
door