NURS 660 EXAM 1 QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS)
5HT1A action - correct answer- Antidepressant;
anxiolytic; potentiation of serotonin levels in the presence of
SRI.
5HT1A drugs - correct answer- Brexpiprazole,
Cariprazine, Lurasidone, Iloperidone.
5HT1a partial agonist - correct answer- Buspirone
(Buspar) may mitigate weight effects of 5HT2C antagonism by
decreasing carb craving.
5HT1B/D - correct answer- Detects 5HT at
presynapse and blocks 5HT release; has antidepressant effects.
5HT1B/D blocking drugs - correct answer-
Iloperidone, Ziprasidone, Asenapine.
5HT2A receptors benefit - correct answer-
Decreased EPS
,5HT2C action - correct answer- Regulates both
dopamine and norepinephrine release; blocking increases
dopamine and norepinephrine from prefrontal cortex.
5HT2C antagonism - correct answer- Causes weight
gain via distribution of hypothalamic neuropeptide Y neurons
and inhibition of pro-opiomelanocortin neurons.
5HT2C benefit - correct answer- unknown
5HT3 action - correct answer- Regulates inhibiting
GABA interneuron; blocking increases serotonin, dopamine,
norepinephrine, acetylcholine, histamine, and is associated with
nausea/vomiting.
5HT6 - correct answer- Key regulator of release of
acetylcholine and cognitive processes; blocking improves
learning and memory in experimental animals.
5HT7 - correct answer- Regulates serotonin release;
blocking disinhibits serotonin release and affects circadian
rhythm.
,Activation - correct answer- The process of making
something active or operational.
Administration of Asenapine - correct answer-
Sublingual; no food or drink for 10 minutes.
Administration of Lurasidone - correct answer- At
least 300 calories of food (book states 500); give at night to
decrease EPS risk.
Administration of Ziprasidone - correct answer-
Twice a day; must take with 500 calories of food; less food
intake lowers absorption by 50%.
Adverse response of alpha 1 adrenergic receptors in aripiprazole
- correct answer- Dizziness, sedation, hypotension
Affective Disturbance Contribution - correct answer-
Affective disturbance can lead to treatment resistance and
violence by attaining 60% occupancy but no response,
necessitating augmentation with mood stabilizers.
, Affective side effects - correct answer- Side effects
that impact emotional states and mood.
Affinity of Low Potency Drugs - correct answer- Low
potency drugs do not have affinity to bind to D2 receptors; they
have more affinity to H1 and M1, leading to more sedation and
dry mouth with less EPS.
Agitation - correct answer- A state of anxiety or
nervousness.
Agranulocytosis - correct answer- A potentially
severe side effect of certain medications, characterized by a
dangerously low level of neutrophils.
Akathesia treatment - correct answer- Includes
benzodiazepines (diazepam, clonazepam, and lorazepam),
propranolol (for orthostatic hypotension and bradycardia), and
mirtazapine (serotonergic treatment).
Akathisia - correct answer- A movement disorder
characterized by a feeling of inner restlessness and an
uncontrollable need to be in constant motion.
DETAILED ANSWERS (VERIFIED ANSWERS)
5HT1A action - correct answer- Antidepressant;
anxiolytic; potentiation of serotonin levels in the presence of
SRI.
5HT1A drugs - correct answer- Brexpiprazole,
Cariprazine, Lurasidone, Iloperidone.
5HT1a partial agonist - correct answer- Buspirone
(Buspar) may mitigate weight effects of 5HT2C antagonism by
decreasing carb craving.
5HT1B/D - correct answer- Detects 5HT at
presynapse and blocks 5HT release; has antidepressant effects.
5HT1B/D blocking drugs - correct answer-
Iloperidone, Ziprasidone, Asenapine.
5HT2A receptors benefit - correct answer-
Decreased EPS
,5HT2C action - correct answer- Regulates both
dopamine and norepinephrine release; blocking increases
dopamine and norepinephrine from prefrontal cortex.
5HT2C antagonism - correct answer- Causes weight
gain via distribution of hypothalamic neuropeptide Y neurons
and inhibition of pro-opiomelanocortin neurons.
5HT2C benefit - correct answer- unknown
5HT3 action - correct answer- Regulates inhibiting
GABA interneuron; blocking increases serotonin, dopamine,
norepinephrine, acetylcholine, histamine, and is associated with
nausea/vomiting.
5HT6 - correct answer- Key regulator of release of
acetylcholine and cognitive processes; blocking improves
learning and memory in experimental animals.
5HT7 - correct answer- Regulates serotonin release;
blocking disinhibits serotonin release and affects circadian
rhythm.
,Activation - correct answer- The process of making
something active or operational.
Administration of Asenapine - correct answer-
Sublingual; no food or drink for 10 minutes.
Administration of Lurasidone - correct answer- At
least 300 calories of food (book states 500); give at night to
decrease EPS risk.
Administration of Ziprasidone - correct answer-
Twice a day; must take with 500 calories of food; less food
intake lowers absorption by 50%.
Adverse response of alpha 1 adrenergic receptors in aripiprazole
- correct answer- Dizziness, sedation, hypotension
Affective Disturbance Contribution - correct answer-
Affective disturbance can lead to treatment resistance and
violence by attaining 60% occupancy but no response,
necessitating augmentation with mood stabilizers.
, Affective side effects - correct answer- Side effects
that impact emotional states and mood.
Affinity of Low Potency Drugs - correct answer- Low
potency drugs do not have affinity to bind to D2 receptors; they
have more affinity to H1 and M1, leading to more sedation and
dry mouth with less EPS.
Agitation - correct answer- A state of anxiety or
nervousness.
Agranulocytosis - correct answer- A potentially
severe side effect of certain medications, characterized by a
dangerously low level of neutrophils.
Akathesia treatment - correct answer- Includes
benzodiazepines (diazepam, clonazepam, and lorazepam),
propranolol (for orthostatic hypotension and bradycardia), and
mirtazapine (serotonergic treatment).
Akathisia - correct answer- A movement disorder
characterized by a feeling of inner restlessness and an
uncontrollable need to be in constant motion.
