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What is the difference between metaplasia and dysplasia?
Metaplasia is replacement of one mature cell type by another, whereas
dysplasia is disordered abnormal growth and maturation.
What is the difference between dysplasia and neoplasia?
Dysplasia is abnormal disordered growth that may be premalignant,
whereas neoplasia is autonomous uncontrolled new growth.
What is the difference between physiologic and pathologic adaptation?
Physiologic adaptation occurs as a normal response, whereas pathologic
adaptation occurs in response to disease or harmful stress.
What is cellular injury?
Cellular injury is damage to cell structure or function caused by stress that
exceeds the cell's adaptive capacity.
,What are the two major outcomes of cellular injury?
Cellular injury may be reversible or irreversible.
What is reversible cell injury?
Reversible cell injury is cell damage that can return to normal if the harmful
stimulus is removed.
What is irreversible cell injury?
Irreversible cell injury is cell damage so severe that the cell cannot
recover and dies.
What is cell death?
Cell death is the irreversible loss of cell viability and function.
What are the two major types of cell death students should know first?
Apoptosis and necrosis are the two major types.
What is apoptosis?
Apoptosis is programmed, regulated cell death in which the cell is removed in
an orderly manner.
,What is necrosis?
Necrosis is uncontrolled pathologic cell death caused by severe injury, usually
with membrane breakdown and inflammation.
What is the main difference between apoptosis and necrosis?
Apoptosis is regulated and orderly, whereas necrosis is uncontrolled and
injurious to surrounding tissue.
What is degeneration in a cell or tissue?
Degeneration is deterioration of cell or tissue structure and function,
often due to injury or abnormal metabolism.
What is fatty change, or steatosis?
Fatty change is abnormal accumulation of triglycerides within cells, especially
parenchymal cells.
What is cellular swelling?
Cellular swelling is an increase in cell volume due to failure of ion and
water balance, often seen in reversible injury.
What is hydropic change?
Hydropic change is cellular swelling caused by water accumulation within
the cell.
, What is vacuolar degeneration?
Vacuolar degeneration is the appearance of cytoplasmic vacuoles, often
reflecting cell injury and disturbed water or organelle balance.
What is intracellular accumulation?
Intracellular accumulation is abnormal buildup of substances such as
lipids, proteins, pigments, glycogen, or water inside cells.
What is calcification?
Calcification is abnormal deposition of calcium salts in tissues.
What is dystrophic calcification?
Dystrophic calcification is calcium deposition in damaged or necrotic tissue
despite normal serum calcium levels.
What is metastatic calcification?
Metastatic calcification is calcium deposition in otherwise normal tissue
due to elevated serum calcium levels.
What is inflammation?
Inflammation is the tissue response to injury or infection characterized by
vascular, cellular, and molecular reactions.