1. Which of the following antifungal agents is MOST likely to cause neurotoxicity?
A. Fluconazole. B. Amphotericin B. C. Itraconazole. D. Posaconazole
2. Which of the following antifungal agents should be avoided in patients with evidence of
ventricular dysfunction?
A. Micafungin. B. Itraconazole. C. Terbinafine. D. Posaconazole
3. Which of the following is the drug of choice for aspergillosis
A. Voriconazole. B. Fluconazole. C. Flucytosine. D. Ketoconazole.
4. Which of the following is the most appropriate choice for treating onchomycosis?
A. Terbinafine. B. Micafungin. C. Itraconazole. D. Griseofulvin
5. Which class of antifungal drugs inhibits the enzyme 14-alpha-demethylase?
a) Azoles b) Polyenes c) Echinocandins d) Allylamines
6. Which antifungal drug is often used topically to treat superficial fungal infections such as
athlete's foot?
a) Fluconazole b) Amphotericin B c) Terbinafine d) Caspofungin
7. Which antifungal drug can cause nephrotoxicity and electrolyte imbalances as significant
adverse effects?
a) Amphotericin B b) Fluconazole c) Griseofulvin d) Voriconazole
8. Which antifungal drug is commonly used for the treatment of systemic fungal infections like
cryptococcal meningitis and candidiasis?
a) Nystatin b) Terbinafine c) Itraconazole d) Caspofungin
9. Which class of antifungal drugs disrupts fungal cell wall synthesis?
a) Azoles b) Echinocandins c) Polyenes d) Allylamines
10. What is the primary target of antifungal drugs?
a) Bacterial cell wall b) Fungal cell membrane
c) Fungal DNA d) Fungal ribosomes
Short questions ( 2x5= 10 marks)
Qno1: classify Antifungal drugs
Qno2: Write a note on Azoles