Corticosteroi
ds
, History
• 1855 – Addison's disease
• 1856 – Adrenal glands essential for life
• 1930 – Cortex > medulla
• 1932 – Cushing’s syndrome
• 1949 – Hench et al (Steroids in rheumatoid arthritis)
• 1952 – Aldosterone
, Synthesis
Principal
Stimuli Part
product
Angiotensin Zona Aldosterone
II glomerulosa
Cortisol
Zona
Adrenal
ACTH fasiculata & androgens
reticularis Adrenaline
&
Sympathetic
Nor-
nervous adrenaline
Medulla
system
ds
, History
• 1855 – Addison's disease
• 1856 – Adrenal glands essential for life
• 1930 – Cortex > medulla
• 1932 – Cushing’s syndrome
• 1949 – Hench et al (Steroids in rheumatoid arthritis)
• 1952 – Aldosterone
, Synthesis
Principal
Stimuli Part
product
Angiotensin Zona Aldosterone
II glomerulosa
Cortisol
Zona
Adrenal
ACTH fasiculata & androgens
reticularis Adrenaline
&
Sympathetic
Nor-
nervous adrenaline
Medulla
system