NURS 611 Advanced Pathophysiology Week 4 Quiz: Hematology 2026
|Maryville
1. Which hormone, primarily synthesized in the peritubular cells of the kidney,
is the main regulator of erythropoiesis?
A. Thrombopoietin
B. Aldosterone
C. Erythropoietin
D. Somatotropin
Answer: C
Rationale: Erythropoietin is secreted by the kidneys in response to tissue hypoxia,
stimulating the bone marrow to produce red blood cells.
2. In Pernicious Anemia, the underlying pathophysiology involves a lack of
which substance?
A. Hydrochloric acid
B. Folic acid
C. Intrinsic factor
D. Ferritin
Answer: C
Rationale: Pernicious anemia is caused by an autoimmune-mediated deficiency of intrinsic
factor, which is required for Vitamin B12 absorption in the ileum.
,3. Which of the following describes the morphological classification of Iron
Deficiency Anemia?
A. Microcytic-Hypochromic
B. Macrocytic-Normochromic
C. Normocytic-Normochromic
D. Microcytic-Hyperchromic
Answer: A
Rationale: Iron deficiency leads to smaller (microcytic) and paler (hypochromic) red blood
cells due to reduced hemoglobin synthesis.
4. Which genetic translocation is the hallmark of Chronic Myeloid Leukemia
(CML)?
A. t(8;14)
B. t(15;17)
C. t(9;22)
D. t(11;14)
Answer: C
Rationale: The Philadelphia chromosome, a translocation between chromosomes 9 and 22,
creates the BCR-ABL fusion gene seen in CML.
5. Reed-Sternberg cells are a diagnostic marker for which condition?
A. Non-Hodgkin Lymphoma
B. Multiple Myeloma
C. Acute Myeloid Leukemia
D. Hodgkin Lymphoma
Answer: D
Rationale: Reed-Sternberg cells are large, multinucleated malignant B-cells characteristic
of Hodgkin Lymphoma.
, 6. What is the primary function of the Von Willebrand factor (vWF)?
A. Platelet adhesion to damaged endothelium
B. Activating Protein C
C. Converting Fibrinogen to Fibrin
D. Inhibiting Antithrombin III
Answer: A
Rationale: vWF acts as a bridge between the subendothelial collagen and the platelet
surface glycoprotein Ib, facilitating adhesion.
7. In Disseminated Intravascular Coagulation (DIC), what is the primary cause of
widespread hemorrhage?
A. Overproduction of Heparin
B. Inhibition of the fibrinolytic system
C. Excessive Vitamin K production
D. Depletion of clotting factors and platelets
Answer: D
Rationale: DIC involves systemic activation of coagulation which consumes platelets and
clotting factors, leading to a secondary bleeding state.
8. Which protein is the primary storage form of iron in the liver?
A. Ferritin
B. Hemosiderin
C. Transferrin
D. Albumin
Answer: A
Rationale: Ferritin is the intracellular protein that stores iron and releases it in a
controlled fashion.
|Maryville
1. Which hormone, primarily synthesized in the peritubular cells of the kidney,
is the main regulator of erythropoiesis?
A. Thrombopoietin
B. Aldosterone
C. Erythropoietin
D. Somatotropin
Answer: C
Rationale: Erythropoietin is secreted by the kidneys in response to tissue hypoxia,
stimulating the bone marrow to produce red blood cells.
2. In Pernicious Anemia, the underlying pathophysiology involves a lack of
which substance?
A. Hydrochloric acid
B. Folic acid
C. Intrinsic factor
D. Ferritin
Answer: C
Rationale: Pernicious anemia is caused by an autoimmune-mediated deficiency of intrinsic
factor, which is required for Vitamin B12 absorption in the ileum.
,3. Which of the following describes the morphological classification of Iron
Deficiency Anemia?
A. Microcytic-Hypochromic
B. Macrocytic-Normochromic
C. Normocytic-Normochromic
D. Microcytic-Hyperchromic
Answer: A
Rationale: Iron deficiency leads to smaller (microcytic) and paler (hypochromic) red blood
cells due to reduced hemoglobin synthesis.
4. Which genetic translocation is the hallmark of Chronic Myeloid Leukemia
(CML)?
A. t(8;14)
B. t(15;17)
C. t(9;22)
D. t(11;14)
Answer: C
Rationale: The Philadelphia chromosome, a translocation between chromosomes 9 and 22,
creates the BCR-ABL fusion gene seen in CML.
5. Reed-Sternberg cells are a diagnostic marker for which condition?
A. Non-Hodgkin Lymphoma
B. Multiple Myeloma
C. Acute Myeloid Leukemia
D. Hodgkin Lymphoma
Answer: D
Rationale: Reed-Sternberg cells are large, multinucleated malignant B-cells characteristic
of Hodgkin Lymphoma.
, 6. What is the primary function of the Von Willebrand factor (vWF)?
A. Platelet adhesion to damaged endothelium
B. Activating Protein C
C. Converting Fibrinogen to Fibrin
D. Inhibiting Antithrombin III
Answer: A
Rationale: vWF acts as a bridge between the subendothelial collagen and the platelet
surface glycoprotein Ib, facilitating adhesion.
7. In Disseminated Intravascular Coagulation (DIC), what is the primary cause of
widespread hemorrhage?
A. Overproduction of Heparin
B. Inhibition of the fibrinolytic system
C. Excessive Vitamin K production
D. Depletion of clotting factors and platelets
Answer: D
Rationale: DIC involves systemic activation of coagulation which consumes platelets and
clotting factors, leading to a secondary bleeding state.
8. Which protein is the primary storage form of iron in the liver?
A. Ferritin
B. Hemosiderin
C. Transferrin
D. Albumin
Answer: A
Rationale: Ferritin is the intracellular protein that stores iron and releases it in a
controlled fashion.
