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First Aid for Psychiatry
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Treatment for panic disorder
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Treatment for panic disorder
Acute: BenzodiazepinesLong term: SSRI/SNRI + CBT
Psychosis (definition)
any of :- disordered thought (content/process)- delusions (paranoid, ideas of reference, thought broadcasting, grandeur, guilt)-
Perceptual disturbances (illusions, hallucinations: visual, auditory, olfactory, tactile)
SchizophreniaDiagnosis, DSM IV criteria
Any of the following present for 6 months and longer:1. Delusions2. Hallucinations3. Disorganized speech4. grossly
disorganized/catatonic behavior5. Negative symptoms (flat affect)Must cause significant social/ocupatoinal functional deterioration
Schizophrenia: phases of presentation of symptoms (w/ description)
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1. prodrome: decline in functioning prior to first psychotic episode2. psychotic3. residual: b/w psychotic episodes (marked by negative
symptoms)
Patient with schizophrenia:- onset at later age- frequent auditory hallucinations- preoccupation with 1/+ delusions (I'm a spy for the
CIA)- minimal disorganized speech/thought, behavior
Paranoid typePatient description for this type of schizophrenia
Patient with schizophrenia:- early age of onset- disorganized speech- disorganized behavior- flat/inappropriate affect
Disorganized typePatient description in schizophrenia
Patient with schizophrenia:Two of--motor immobility- purposeless motor activity- negativism/mutism- peculiar voluntary
movements/posturing- Echolalia, echopraxia
Catatonic typePatient description with schizophrenia
Patient with schizophrenia:-mainly negative symptoms
Residual typePatient description with schizophrenia
Seasonal effect on incidence of schizophrenia
People born in winter and early spring have higher incidence, for unknown reasons.
Dopamine hypothesis of schizophrenia and evidence for this?
increased DA in neuronal tracts - evidence: DA antagonists are effective treatment
DA pathways affected in schizophrenia, what symptoms does each produce
Prefrontal cortical: negative symptomsMesolimbic: positive symptoms
What (2) drugs mimic chizophrenic-like symptoms ?
cocaine and amphetamines by increasing DAThese drugs mimic what disorder?
Effect of neuroleptics:producing hyperprolactinemiaWhich pathway is affected?
Tuberoinfundibular pathway blocked by neuroleptics, antagonizes DA receptors and removes the inhibition on prolactin
CT findings in patients with schizophrenia
enlargement of ventricles and diffuse cortical atrophy
NT abnormalities in schizophrenia
Elevated DopamineElevated 5-HTElevated NorepiDecreased GABA: d/t loss of neurons in hippocampus
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Characteristics associated with better prognosis in schizophrenia
Later onset, female sex, positive symptoms, acute onsetGood or bad prognosis?
Characteristics for worse prognosis in schizophrenia
early onset, male sex, negative symptoms, family history, gradual onsetGood or bad Px
Side effects of neuroleptics: EPSwhat pathway is involved?
nigrostriatal pathway: bloackade of DA causes Extrapyramidal symptoms
Typical neuroleptics Name 2 high potency and 2 low potency
High potency: Haloperidol, trifluoperazineLow potency: Chlorpromazine, thioridazine
Typical neuroleptics:mechanism of action +S/E
Dopamine (mostly D2) antagonists. Treat positive symptoms betterS/E: EPS, NMS, TDWhat class of drugs
Atypical neurolepticsName some
OlanzapineClozapineQuietiapineRisperidoneAripiprezolZiprasidone
Mechanism of action of Atypical neuroleptics
Antagonists of Dopamine D2 and 5-HT2 receptorsTreat negative symptoms
Antipsychotic medication side effects treatmentEPS
Antiparkinsonian agents: Benztropine, Amantadine, BZs
Antipsychotic medication side effectsAnticholinergic symptoms: caused by?
Low potency typical antipsychotics : chlorpromazine and thioridazineSymptomatic treatment of S/E
Antipsychotic medication side effects treatmentTD (high potency traditionals)
Discontinue offending agent, substitute with atypicalBZs, Beta-blockers, cholinomimetics
Antipsychotic medication side effectsNMS - high potency antipsychotics- presentation?
confusion, high fever, elevated BP, tachycardia, "lead pipe" rigidity, sweating, elevated CPK
Antipsychotic medication side effectsAgranulocytosis- caused by?
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