ATI MEDICATION ADMINISTRATION EXAM
PREP QUESTIONS AND ANSWERS 2026
STUDY GUIDE FULL SOLUTION VIEW
AHEAD
●● __________________ is the study of the absorption, distribution,
metabolism, and excretion (ADME) of medications in the human body..
Answer: Pharmacokinetics
●● How will the medication get into the body?.
Answer: Absorption
●● How will the body break the medication down?.
Answer: Metabolism
●● How will the medication leave the body?.
Answer: Excretion
●● Route of administration:.
Answer: The point where the medication enters the body.
●● Ionization:.
,Answer: The pH of the medication and the site of absorption.
●● Dissolution:.
Answer: The medication must be dissolved before absorption takes
place.
●● Blood flow:.
Answer: Medications are absorbed more rapidly where this is high.
●● Lipid solubility:.
Answer: The medication's formulation can have either high solubility or
low solubility.
●● Surface area of the absorptive site:.
Answer: The size of the area where the medication will be absorbed.
●● Client-specific factors:.
Answer: Pathophysiological processes, diseases or injury, age, and so
on.
●● ____________ _________ tablets readily dissolve when placed on
the tongue, allowing for faster absorption..
Answer: Orally Disintegrating
,●● Many medications are administered by the oral or _________ route,
which provides for a much slower rate of absorption..
Answer: Enteral
●● Medications administered ___________ or ___________ have
variable rates of absorption that reflects the blood flow to the site of
injection..
Answer: -Subcutaneously
-Intramuscularly
●● The ________________ route of administration provides the most
rapid rate of absorption because the medication is directly injected into
the circulatory system through the client's vein. In consequence,
intravenous medications are not affected by the same factors that affect
absorption of medications administered through the other routes..
Answer: Intravenous
●● ______________ medications are applied directly to the area being
treated (e.g., skin, eye, ear, nose), as are transdermal patches. In both
cases, the medication is absorbed through the mucous membranes or
skin in the area of application and moves into the blood through the
capillaries in that area..
Answer: Topical
, ●● The nurse recently administered oral medications to a client who
notified the assistive personnel (AP) that they just vomited. Which of the
following actions should the nurse take first?
A. Notify the provider and obtain further direction
B. Inspect the vomitus for any presence of the medication
C. Document that the client vomited after medication administration
D. Instruct the AP to provide mouth care to the client.
Answer: B. Inspect the vomitus for any presence of the medication
Rationale: It is most important for the nurse to inspect the vomitus for
any evidence of the medication.
●● _____________ is the process of medication delivery to the target
organ or tissues following absorption into the circulatory system..
Answer: Distribution
●● The ____________ and ___________ barriers are protective barriers
that prevent substances, including specific medications, from crossing
them..
Answer: -Blood-brain
-Fetal-placental
●● ___________________ medications cross the barriers more readily..
PREP QUESTIONS AND ANSWERS 2026
STUDY GUIDE FULL SOLUTION VIEW
AHEAD
●● __________________ is the study of the absorption, distribution,
metabolism, and excretion (ADME) of medications in the human body..
Answer: Pharmacokinetics
●● How will the medication get into the body?.
Answer: Absorption
●● How will the body break the medication down?.
Answer: Metabolism
●● How will the medication leave the body?.
Answer: Excretion
●● Route of administration:.
Answer: The point where the medication enters the body.
●● Ionization:.
,Answer: The pH of the medication and the site of absorption.
●● Dissolution:.
Answer: The medication must be dissolved before absorption takes
place.
●● Blood flow:.
Answer: Medications are absorbed more rapidly where this is high.
●● Lipid solubility:.
Answer: The medication's formulation can have either high solubility or
low solubility.
●● Surface area of the absorptive site:.
Answer: The size of the area where the medication will be absorbed.
●● Client-specific factors:.
Answer: Pathophysiological processes, diseases or injury, age, and so
on.
●● ____________ _________ tablets readily dissolve when placed on
the tongue, allowing for faster absorption..
Answer: Orally Disintegrating
,●● Many medications are administered by the oral or _________ route,
which provides for a much slower rate of absorption..
Answer: Enteral
●● Medications administered ___________ or ___________ have
variable rates of absorption that reflects the blood flow to the site of
injection..
Answer: -Subcutaneously
-Intramuscularly
●● The ________________ route of administration provides the most
rapid rate of absorption because the medication is directly injected into
the circulatory system through the client's vein. In consequence,
intravenous medications are not affected by the same factors that affect
absorption of medications administered through the other routes..
Answer: Intravenous
●● ______________ medications are applied directly to the area being
treated (e.g., skin, eye, ear, nose), as are transdermal patches. In both
cases, the medication is absorbed through the mucous membranes or
skin in the area of application and moves into the blood through the
capillaries in that area..
Answer: Topical
, ●● The nurse recently administered oral medications to a client who
notified the assistive personnel (AP) that they just vomited. Which of the
following actions should the nurse take first?
A. Notify the provider and obtain further direction
B. Inspect the vomitus for any presence of the medication
C. Document that the client vomited after medication administration
D. Instruct the AP to provide mouth care to the client.
Answer: B. Inspect the vomitus for any presence of the medication
Rationale: It is most important for the nurse to inspect the vomitus for
any evidence of the medication.
●● _____________ is the process of medication delivery to the target
organ or tissues following absorption into the circulatory system..
Answer: Distribution
●● The ____________ and ___________ barriers are protective barriers
that prevent substances, including specific medications, from crossing
them..
Answer: -Blood-brain
-Fetal-placental
●● ___________________ medications cross the barriers more readily..
