Answers
Other name for Restless Legs Syndrome = Willis-Ekbom disease.
A neurologic condition characterized by an irresistible [RLS]: Definition of Restless Legs Syndrome
urge to move the legs, often accompanied by
unpleasant sensations like tugging or pulling.
[RLS]: Primary vs. Secondary RLS Primary RLS is hereditary or idiopathic;
Secondary RLS stems from underlying medical conditions (e.g., iron deficiency,
diabetes, ESRD) or medications.
[RLS]: Common timing for symptoms Symptoms usually occur or worsen in the evening or at night.
[RLS]: Description of RLS sensations Patients describe them as burning, nagging, aching, electric-current, creepy-
crawly, or "itching-bones".
[RLS]: Symmetry of symptoms Commonly bilateral, though they can be unilateral on occasion.
[RLS]: Effect of activity on symptoms Symptoms worsen during rest/inactivity and improve with movement.
, Risk Factors and Secondary Causes[RLS]: General risk = Family history, female gender, and increasing age.
factors
RLS: Clinical Presentation - Overview
[RLS]: Associated medical conditions Diabetes mellitus, end-stage renal disease (ESRD), iron deficiency, multiple
sclerosis (MS), Parkinson's disease, and venous insufficiency.
[RLS]: Pregnancy and RLS Symptoms often peak in the third trimester and usually resolve after giving
birth.
[RLS]: Lifestyle factors that worsen symptoms Alcohol, caffeine, and nicotine.
[RLS]: Medications that can worsen symptoms Antidepressants (except Bupropion), antipsychotics (e.g., quetiapine,
olanzapine), antiemetics (e.g., metoclopramide), antiepileptics (e.g., topiramate),
and 1st generation antihistamines.
Diagnosis and Classification[RLS]: Number of criteria = All 5 specific criteria must be met.
required for diagnosis