NURS 5461 / NURS5461 Adult Gerontology Management Across the Continuum of Care – Latest Update | 150+ Practice Exam Questions & Verified ฀ANSWERs with Clinical Rationales | UTA Grade A 100% Correct | Geriatric Pharmacokinetics, Pharmacodynami

NURS 5461 / NURS5461 Adult Gerontology Management Across the Continuum of Care
– Latest 2026 2027 Update | 150+ Practice Exam Questions & Verified ฀🎓✓ANSWERs
with Clinical Rationales | UTA Grade A 100% Correct | Geriatric Pharmacokinetics,
Pharmacodynamics, Comprehensive Geriatric Assessment, Cardiovascular Disease



SECTION 1: PHARMACOLOGY AND AGING (Questions 1-20)
Question 1: With age, which of the following changes occurs in body composition that
affects drug distribution?
A. Decreased body fat and increased lean body mass
B. Increased body fat and decreased lean body mass
C. Increased total body water and decreased body fat
D. Decreased body fat and decreased lean body mass

฀🎓✓ANSWER: B

Rationale: With aging, there is increased body fat and decreased lean body mass. This
alters drug distribution so that fat-soluble drugs are distributed more widely and water-
soluble drugs less widely. Increased distribution of fat-soluble drugs can prolong
elimination and increase duration of action, particularly affecting hypnotics and
analgesics.

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Question 2: How does aging affect the volume of distribution for water-soluble drugs?
A. The volume of distribution increases significantly
B. The volume of distribution remains unchanged
C. The volume of distribution is less in the elderly
D. The volume of distribution becomes unpredictable

฀🎓✓ANSWER: C

Rationale: The volume of distribution for water-soluble drugs is less in the elderly due to
decreased total body water and lean body mass. This means water-soluble drugs like
digoxin will have higher serum concentrations in older adults, requiring dose
adjustments.

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