Management (Latest 2026/2027 Update) | Q&A | Grade A | 100%
Correct (Verified Answers) – Nursing Program
Subject: NUR 206 Exam 3 – Diabetes Pathophysiology & Management, GI Disorders (GERD,
PUD, IBS), Respiratory (COPD, Asthma), GU (UTI, BPH, Cancer), Pain Physiology &
Pharmacology
Source: Medical-Surgical Nursing / Pathophysiology / Pharmacology
Format: Q&A Guide with Clinical & Physiological Rationale | 100% Verified
1: What is the pathophysiology of Type 1 Diabetes?
Correct Answer: Autoimmune destruction of pancreatic beta cells → no insulin production →
hyperglycemia
1. T-cell mediated attack on islet cells; absolute insulin deficiency.
2. Requires lifelong exogenous insulin; ketosis-prone.
2: What are the 3 P's of Type 1 Diabetes?
Correct Answer: Polyuria (osmotic diuresis), Polydipsia, Polyphagia
1. Hyperglycemia exceeds renal threshold → glucosuria → osmotic diuresis.
2. Dehydration triggers thirst; cellular starvation triggers hunger.
3: What are symptoms of hypoglycemia?
Correct Answer: Tremor, tachycardia, diaphoresis, confusion, irritability, seizures
1. Sympathetic response: tremor, tachycardia, sweating.
2. Neuroglycopenia: confusion, seizures, coma; treat with rapid glucose.
4: What are acute complications of diabetes?
Correct Answer: Hypoglycemia, DKA (diabetic ketoacidosis), HHS (hyperglycemic hyperosmolar
state)
1. DKA more common in Type 1; HHS more common in Type 2.
2. Both are life-threatening emergencies.
5: What are microvascular complications of diabetes?
Correct Answer: Retinopathy, nephropathy, neuropathy
1. Chronic hyperglycemia damages small vessels.
2. Leading causes of blindness, ESRD, and amputations.
6: What are macrovascular complications of diabetes?
Correct Answer: Cardiovascular disease, cerebrovascular disease, peripheral vascular disease
1. Accelerated atherosclerosis affects large arteries.
2. MI and stroke are leading causes of death in diabetes.
, 7: What is the mechanism of action of sulfonylureas?
Correct Answer: Used to treat Type 2 diabetes; stimulates pancreas to release more insulin; closes K-
ATP channels in pancreatic beta cells → ↑ insulin secretion
1. Examples: glipizide, glyburide.
2. Risk of hypoglycemia, weight gain.
8: What are the onset, peak, and duration of rapid-acting insulin (Lispro)?
Correct Answer: Onset: ~15 min; Peak: ~1 hour; Duration: 2-4 hours; Give with meals
1. Rapid-acting analogs (Lispro, Aspart) mimic physiologic prandial insulin.
2. Inject just before or with meals.
9: What are the onset, peak, and duration of short-acting insulin (Regular)?
Correct Answer: Onset: 30-60 min; Peak: 2-6 hours; Duration: 3-8 hours; Give 30 min before meals;
ONLY insulin you can give IV
1. Regular insulin is the only form approved for intravenous administration.
2. Used for DKA treatment via IV drip.
10: What are the onset, peak, and duration of intermediate insulin (NPH)?
Correct Answer: Onset: 2-4 hours; Peak: 4-10 hours; Duration: 10-20 hours; Cloudy insulin; Has a
PEAK
1. NPH provides basal coverage with a pronounced peak.
2. Must shake/rotate to resuspend; monitor for peak hypoglycemia.
11: What are the characteristics of long-acting insulin Glargine (Lantus)?
Correct Answer: Long acting; provides steady basal insulin all day; Onset: ~1 hour; NO PEAK;
Duration: ~24 hours
1. Clear solution; do not mix in same syringe with other insulins.
2. Neutral pH prevents precipitation when mixed.
12: What is the insulin mixing rule?
Correct Answer: Draw clear (regular) before cloudy (NPH)
1. Prevents contamination of clear insulin vial with cloudy insulin.
2. "Clear to cloudy" mnemonic.
13: What does Hemoglobin A1C measure?
Correct Answer: Average blood glucose over 2-3 months; based on irreversible glycosylation of RBCs
1. Goal for most diabetics: A1C <7%.
2. RBC lifespan ~120 days; reflects glycemic control.
14: What is the Somogyi Effect?
Correct Answer: Morning hyperglycemia caused by nighttime hypoglycemia (too much insulin)
1. Counterregulatory hormones (glucagon, cortisol) cause rebound hyperglycemia.
2. Treatment: decrease evening insulin or add bedtime snack.