USMLE Step 1 Rapid Review
QUESTIONS AND VERIFIED CORRECT
ANSWERS GRADED A+ LATEST 100%
GUARANTEED PASS
Green-yellow rings around peripheral iris - CORRECT ANSWER-Kayser-Fleischer rings (copper
accumulation from Wilson's disease)
Hamartomatous GI polyps, hyperpigmentation of mouth, feet and hands - CORRECT ANSWER-
Peutz-Jeghers syndrome
Hepatosplenomegaly, osteoporosis, neurologic symptoms, crinkled cytoplasm - CORRECT
ANSWER-Gaucher's disease (glucocerebrosidase deficiency)
Hereditary nephritis, sensorineural hearing loss, cataracts - CORRECT ANSWER-Alport's
syndrome (type IV collagen)
Hypercoagulability leading to thrombophlebitis - CORRECT ANSWER-Trousseau's sign
(adenocarcinoma of pancreas or lung)
Hyperphagia, hypersexuality, hyperorality, hyperdocility - CORRECT ANSWER-Kluver-Bucy
syndrome (bilateral amygdala)
HTN, hypoK, metabolic alkalosis - CORRECT ANSWER-Conn's (1* hyperaldosterone)
,Hypoxemia, polycythemia, hypercapnia - CORRECT ANSWER-Blue bloater (chronic bronchitis)
Indurated, ulcerated genital lesion - CORRECT ANSWER-Nonpainful = syphillis. Painful with
exudate = chancroid
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration - CORRECT ANSWER-
Niemann-Pick disease (genetic sphingomyelinase deficiency)
Infant with hypoglycemia, failure to thrive, and hepatomegaly - CORRECT ANSWER-Cori's
disease (debranching enzyme deficiency, no glycogenolysis) or Von Gierke's
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect -
CORRECT ANSWER-Edward's syndrome (Trisomy 18)
Jaundice, RUQ pain, fever - CORRECT ANSWER-Charcot's triad (ascending cholangitis)
Keratin pearls - CORRECT ANSWER-Squamous cell carcinoma
Large rash with bull's eye appearance - CORRECT ANSWER-Erythema chronicum migrans from
Ixodes tick bite (Lyme)
Lucid interval after TBI - CORRECT ANSWER-Epidural hematoma (middle meningeal artery)
Male child, recurrent infections, no mature B cells - CORRECT ANSWER-Bruton's disease (X-
linked agammaglobulinemia)
Mucosal bleeding and prolonged bleeding time - CORRECT ANSWER-Glanzmann's
thrombasthenia (defect in platelet aggregation due to lack of GpIIb/IIIa)
, Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumary teeth - CORRECT
ANSWER-Gardner's syndrome
Necrotizing vasculitis (lungs) and necrotizing GN - CORRECT ANSWER-Wegner's (c-ANCA) and
Goodpasture's (anti-GBM). Wegner's can also have upper airway involvement
Neonate with arm paralysis following difficult birth. Possible clavicle fx, probably large for
gestational age - CORRECT ANSWER-Erb-Duchenne palsy
No lactation postpartum, absent menstruation, cold intolerance - CORRECT ANSWER-Sheehan's
syndrome
Nystagmus, intention tremor, scanning speech, also bilateral internuclear ophthalmoplegia -
CORRECT ANSWER-MS (Charcot's)
Oscillating slow / fast breathing - CORRECT ANSWER-Cheyne-Stokes (central apnea from CHF or
increased ICP)
Painful blue fingers / toes, hemolytic anemia - CORRECT ANSWER-Cold agglutinin disease
(autoimmune from Mp or mono, from IgM)
Painful, pale, cold fingers / toes - CORRECT ANSWER-Raynaud's syndrome (vasospasm)
Painful, raised red lesions on palms and soles - CORRECT ANSWER-Osler's node (infective
endocarditis)
Painless erythematous lesions on palms and soles - CORRECT ANSWER-Janeway lesions
(infective endocarditis)
QUESTIONS AND VERIFIED CORRECT
ANSWERS GRADED A+ LATEST 100%
GUARANTEED PASS
Green-yellow rings around peripheral iris - CORRECT ANSWER-Kayser-Fleischer rings (copper
accumulation from Wilson's disease)
Hamartomatous GI polyps, hyperpigmentation of mouth, feet and hands - CORRECT ANSWER-
Peutz-Jeghers syndrome
Hepatosplenomegaly, osteoporosis, neurologic symptoms, crinkled cytoplasm - CORRECT
ANSWER-Gaucher's disease (glucocerebrosidase deficiency)
Hereditary nephritis, sensorineural hearing loss, cataracts - CORRECT ANSWER-Alport's
syndrome (type IV collagen)
Hypercoagulability leading to thrombophlebitis - CORRECT ANSWER-Trousseau's sign
(adenocarcinoma of pancreas or lung)
Hyperphagia, hypersexuality, hyperorality, hyperdocility - CORRECT ANSWER-Kluver-Bucy
syndrome (bilateral amygdala)
HTN, hypoK, metabolic alkalosis - CORRECT ANSWER-Conn's (1* hyperaldosterone)
,Hypoxemia, polycythemia, hypercapnia - CORRECT ANSWER-Blue bloater (chronic bronchitis)
Indurated, ulcerated genital lesion - CORRECT ANSWER-Nonpainful = syphillis. Painful with
exudate = chancroid
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration - CORRECT ANSWER-
Niemann-Pick disease (genetic sphingomyelinase deficiency)
Infant with hypoglycemia, failure to thrive, and hepatomegaly - CORRECT ANSWER-Cori's
disease (debranching enzyme deficiency, no glycogenolysis) or Von Gierke's
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect -
CORRECT ANSWER-Edward's syndrome (Trisomy 18)
Jaundice, RUQ pain, fever - CORRECT ANSWER-Charcot's triad (ascending cholangitis)
Keratin pearls - CORRECT ANSWER-Squamous cell carcinoma
Large rash with bull's eye appearance - CORRECT ANSWER-Erythema chronicum migrans from
Ixodes tick bite (Lyme)
Lucid interval after TBI - CORRECT ANSWER-Epidural hematoma (middle meningeal artery)
Male child, recurrent infections, no mature B cells - CORRECT ANSWER-Bruton's disease (X-
linked agammaglobulinemia)
Mucosal bleeding and prolonged bleeding time - CORRECT ANSWER-Glanzmann's
thrombasthenia (defect in platelet aggregation due to lack of GpIIb/IIIa)
, Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumary teeth - CORRECT
ANSWER-Gardner's syndrome
Necrotizing vasculitis (lungs) and necrotizing GN - CORRECT ANSWER-Wegner's (c-ANCA) and
Goodpasture's (anti-GBM). Wegner's can also have upper airway involvement
Neonate with arm paralysis following difficult birth. Possible clavicle fx, probably large for
gestational age - CORRECT ANSWER-Erb-Duchenne palsy
No lactation postpartum, absent menstruation, cold intolerance - CORRECT ANSWER-Sheehan's
syndrome
Nystagmus, intention tremor, scanning speech, also bilateral internuclear ophthalmoplegia -
CORRECT ANSWER-MS (Charcot's)
Oscillating slow / fast breathing - CORRECT ANSWER-Cheyne-Stokes (central apnea from CHF or
increased ICP)
Painful blue fingers / toes, hemolytic anemia - CORRECT ANSWER-Cold agglutinin disease
(autoimmune from Mp or mono, from IgM)
Painful, pale, cold fingers / toes - CORRECT ANSWER-Raynaud's syndrome (vasospasm)
Painful, raised red lesions on palms and soles - CORRECT ANSWER-Osler's node (infective
endocarditis)
Painless erythematous lesions on palms and soles - CORRECT ANSWER-Janeway lesions
(infective endocarditis)
