First Aid-USMLE STEP 1 High Yield
QUESTIONS AND VERIFIED CORRECT
ANSWERS GRADED A+ LATEST 100%
GUARANTEED PASS
Hereditary nephritis, sensorineural hearing loss, cataracts - CORRECT ANSWER-Alport syndrome
(mutation in collagen IV)
Hyperphagia, hypersexuality, hyperorality, hyperdocility - CORRECT ANSWER-Klüver-Bucy
syndrome (bilateral amygdala lesion)
Hyperreflexia, hypertonia, Babinski sign present - CORRECT ANSWER-UMN damage
Hyporeflexia, hypotonia, atrophy, fasciculations - CORRECT ANSWER-LMN damage
Hypoxemia, polycythemia, hypercapnia - CORRECT ANSWER-"Blue bloater" (chronic bronchitis:
hyperplasia of mucous cells)
Indurated, ulcerated genital lesion - CORRECT ANSWER-Nonpainful: chancre (1° syphilis,
Treponema pallidum) Painful, with exudate: chancroid (Haemophilus ducreyi)
Infant with "cherry-red" spot on macula, hepatosplenomegaly, and neurodegeneration -
CORRECT ANSWER-Niemann-Pick disease (genetic sphingomyelinase deficiency)
,Infant with cleft lip/palate, microcephaly or holoprosencephaly, polydactyly, cutis aplasia -
CORRECT ANSWER-Patau syndrome (trisomy 13)
Infant with hypoglycemia, hepatomegaly - CORRECT ANSWER-Cori disease (debranching
enzyme deficiency) or Von Gierke disease (glucose-6-phosphatase deficiency, more severe)
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect -
CORRECT ANSWER-Edwards syndrome (trisomy 18)
Jaundice, palpable distended non-tender gallbladder - CORRECT ANSWER-Courvoisier sign
(distal obstruction of biliary tree)
Large rash with bull's-eye appearance - CORRECT ANSWER-Erythema chronicum migrans from
Ixodes tick bite (Lyme disease: Borrelia)
Lucid interval after traumatic brain injury - CORRECT ANSWER-Epidural hematoma (middle
meningeal artery rupture)
Male child, recurrent infections, no mature B cells - CORRECT ANSWER-Bruton disease (X-linked
agammaglobulinemia)
Mucosal bleeding and prolonged bleeding time - CORRECT ANSWER-Glanzmann
thrombasthenia (defect in platelet aggregation due to lack of GpIIb/IIIa)
Muffled heart sounds, distended neck veins, hypotension - CORRECT ANSWER-Beck triad of
cardiac tamponade
,Multiple colon polyps, osteomas/soft tissue tumors, impacted/ supernumerary teeth - CORRECT
ANSWER-Gardner syndrome (subtype of FAP)
Myopathy (infantile hypertrophic cardiomyopathy), exercise intolerance - CORRECT ANSWER-
Pompe disease (lysosomal α-1,4-glucosidase deficiency)
Neonate with arm paralysis following difficult birth - CORRECT ANSWER-Erb-Duchenne palsy
(superior trunk [C5-C6] brachial plexus injury: "waiter's tip")
No lactation postpartum, absent menstruation, cold intolerance - CORRECT ANSWER-Sheehan
syndrome (pituitary infarction)
Nystagmus, intention tremor, scanning speech, bilateral internuclear ophthalmoplegia -
CORRECT ANSWER-Multiple sclerosis
Painful blue fingers/toes, hemolytic anemia - CORRECT ANSWER-Cold agglutinin disease
(autoimmune hemolytic anemia caused by Mycoplasma pneumoniae, infectious
mononucleosis, CLL) [IgM]
Painful fingers/toes changing color from blue to white to red with cold or stress - CORRECT
ANSWER-Raynaud phenomenon (vasospasm in extremities)
Painful, raised red lesions on pads of fingers/toes - CORRECT ANSWER-Osler nodes (infective
endocarditis, immune complex deposition)
Painless erythematous lesions on palms and soles - CORRECT ANSWER-Janeway lesions
(infective endocarditis, septic emboli/ microabscesses)
-The emboli are fragments of infected intracardiac vegetations
-In CONTRAST to Janeway lesions, Osler nodes are painful, papulopustules found in the pulps of
the fingers and toes
, Painless jaundice - CORRECT ANSWER-Cancer of the pancreatic head obstructing bile duct
Palpable purpura on buttocks/legs, joint pain, abdominal pain (child), hematuria - CORRECT
ANSWER-Henoch-Schönlein purpura (IgA vasculitis affecting skin and kidneys)
Pancreatic, pituitary, parathyroid tumors - CORRECT ANSWER-MEN 1 (autosomal dominant)
Periorbital and/or peripheral edema, proteinuria, hypoalbuminemia, hypercholesterolemia -
CORRECT ANSWER-Nephrotic syndrome
Pink complexion, dyspnea, hyperventilation - CORRECT ANSWER-"Pink puffer" (emphysema:
centriacinar [smoking], panacinar [α1-antitrypsin deficiency])
-α1-antitrypsin deficiency: uninhibited elastase in alveoli --> Decrease in elastic tissue -->
panacina emphysema
-Increase in elastase activity --> loss of elastic fibers -->Increase in Lung compliance
-Barrel Shaped Chest
Polyuria, renal tubular acidosis type II, growth failure, electrolyte imbalances,
hypophosphatemic rickets - CORRECT ANSWER-Fanconi syndrome (multiple combined
dysfunction of the PCT)
Pruritic, purple, polygonal planar papules and plaques (6 P's) - CORRECT ANSWER-Lichen planus
Ptosis, miosis, anhidrosis - CORRECT ANSWER-Horner syndrome (sympathetic chain lesion)
Pupil accommodates but doesn't react - CORRECT ANSWER-Argyll Robertson pupil
(neurosyphilis)
QUESTIONS AND VERIFIED CORRECT
ANSWERS GRADED A+ LATEST 100%
GUARANTEED PASS
Hereditary nephritis, sensorineural hearing loss, cataracts - CORRECT ANSWER-Alport syndrome
(mutation in collagen IV)
Hyperphagia, hypersexuality, hyperorality, hyperdocility - CORRECT ANSWER-Klüver-Bucy
syndrome (bilateral amygdala lesion)
Hyperreflexia, hypertonia, Babinski sign present - CORRECT ANSWER-UMN damage
Hyporeflexia, hypotonia, atrophy, fasciculations - CORRECT ANSWER-LMN damage
Hypoxemia, polycythemia, hypercapnia - CORRECT ANSWER-"Blue bloater" (chronic bronchitis:
hyperplasia of mucous cells)
Indurated, ulcerated genital lesion - CORRECT ANSWER-Nonpainful: chancre (1° syphilis,
Treponema pallidum) Painful, with exudate: chancroid (Haemophilus ducreyi)
Infant with "cherry-red" spot on macula, hepatosplenomegaly, and neurodegeneration -
CORRECT ANSWER-Niemann-Pick disease (genetic sphingomyelinase deficiency)
,Infant with cleft lip/palate, microcephaly or holoprosencephaly, polydactyly, cutis aplasia -
CORRECT ANSWER-Patau syndrome (trisomy 13)
Infant with hypoglycemia, hepatomegaly - CORRECT ANSWER-Cori disease (debranching
enzyme deficiency) or Von Gierke disease (glucose-6-phosphatase deficiency, more severe)
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect -
CORRECT ANSWER-Edwards syndrome (trisomy 18)
Jaundice, palpable distended non-tender gallbladder - CORRECT ANSWER-Courvoisier sign
(distal obstruction of biliary tree)
Large rash with bull's-eye appearance - CORRECT ANSWER-Erythema chronicum migrans from
Ixodes tick bite (Lyme disease: Borrelia)
Lucid interval after traumatic brain injury - CORRECT ANSWER-Epidural hematoma (middle
meningeal artery rupture)
Male child, recurrent infections, no mature B cells - CORRECT ANSWER-Bruton disease (X-linked
agammaglobulinemia)
Mucosal bleeding and prolonged bleeding time - CORRECT ANSWER-Glanzmann
thrombasthenia (defect in platelet aggregation due to lack of GpIIb/IIIa)
Muffled heart sounds, distended neck veins, hypotension - CORRECT ANSWER-Beck triad of
cardiac tamponade
,Multiple colon polyps, osteomas/soft tissue tumors, impacted/ supernumerary teeth - CORRECT
ANSWER-Gardner syndrome (subtype of FAP)
Myopathy (infantile hypertrophic cardiomyopathy), exercise intolerance - CORRECT ANSWER-
Pompe disease (lysosomal α-1,4-glucosidase deficiency)
Neonate with arm paralysis following difficult birth - CORRECT ANSWER-Erb-Duchenne palsy
(superior trunk [C5-C6] brachial plexus injury: "waiter's tip")
No lactation postpartum, absent menstruation, cold intolerance - CORRECT ANSWER-Sheehan
syndrome (pituitary infarction)
Nystagmus, intention tremor, scanning speech, bilateral internuclear ophthalmoplegia -
CORRECT ANSWER-Multiple sclerosis
Painful blue fingers/toes, hemolytic anemia - CORRECT ANSWER-Cold agglutinin disease
(autoimmune hemolytic anemia caused by Mycoplasma pneumoniae, infectious
mononucleosis, CLL) [IgM]
Painful fingers/toes changing color from blue to white to red with cold or stress - CORRECT
ANSWER-Raynaud phenomenon (vasospasm in extremities)
Painful, raised red lesions on pads of fingers/toes - CORRECT ANSWER-Osler nodes (infective
endocarditis, immune complex deposition)
Painless erythematous lesions on palms and soles - CORRECT ANSWER-Janeway lesions
(infective endocarditis, septic emboli/ microabscesses)
-The emboli are fragments of infected intracardiac vegetations
-In CONTRAST to Janeway lesions, Osler nodes are painful, papulopustules found in the pulps of
the fingers and toes
, Painless jaundice - CORRECT ANSWER-Cancer of the pancreatic head obstructing bile duct
Palpable purpura on buttocks/legs, joint pain, abdominal pain (child), hematuria - CORRECT
ANSWER-Henoch-Schönlein purpura (IgA vasculitis affecting skin and kidneys)
Pancreatic, pituitary, parathyroid tumors - CORRECT ANSWER-MEN 1 (autosomal dominant)
Periorbital and/or peripheral edema, proteinuria, hypoalbuminemia, hypercholesterolemia -
CORRECT ANSWER-Nephrotic syndrome
Pink complexion, dyspnea, hyperventilation - CORRECT ANSWER-"Pink puffer" (emphysema:
centriacinar [smoking], panacinar [α1-antitrypsin deficiency])
-α1-antitrypsin deficiency: uninhibited elastase in alveoli --> Decrease in elastic tissue -->
panacina emphysema
-Increase in elastase activity --> loss of elastic fibers -->Increase in Lung compliance
-Barrel Shaped Chest
Polyuria, renal tubular acidosis type II, growth failure, electrolyte imbalances,
hypophosphatemic rickets - CORRECT ANSWER-Fanconi syndrome (multiple combined
dysfunction of the PCT)
Pruritic, purple, polygonal planar papules and plaques (6 P's) - CORRECT ANSWER-Lichen planus
Ptosis, miosis, anhidrosis - CORRECT ANSWER-Horner syndrome (sympathetic chain lesion)
Pupil accommodates but doesn't react - CORRECT ANSWER-Argyll Robertson pupil
(neurosyphilis)
