2026/2027 | AC-HPAT Health Program
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Section 1: Reading Comprehension
Passage 1: Informational (Sleep and Health)
Chronic sleep deprivation is increasingly recognized as a public health epidemic. While individual sleep
needs vary, adults generally require between 7 and 9 hours of sleep per night. Failing to meet this
threshold has been linked to a myriad of health issues, including obesity, diabetes, and cardiovascular
disease. The mechanism is partly hormonal; sleep deprivation increases levels of ghrelin, the "hunger
hormone," while decreasing leptin, which signals satiety. This hormonal imbalance leads to increased
appetite and potential weight gain. Furthermore, during deep sleep stages, blood pressure drops, giving
the heart and blood vessels a chance to rest. Consequently, those who sleep less than six hours a night
have a significantly higher risk of coronary heart disease.
Q1: What is the main idea of the passage?
A. Ghrelin and leptin are the primary causes of obesity.
B. Chronic sleep deprivation has severe negative consequences for physical health. [CORRECT]
C. Adults need at least six hours of sleep to function.
D. Cardiovascular disease is the most dangerous result of sleep loss.
Correct Answer: B
Rationale: [CORRECT] The passage broadly discusses the various negative health outcomes (obesity,
diabetes, heart disease) resulting from not getting enough sleep. A – This focuses only on the
mechanism for obesity, ignoring the cardiovascular points. C – The passage states adults need 7-9 hours,
and implies less than 6 is risky, but this is a detail. D – The passage lists several risks; it does not rank
cardiovascular disease as the "most dangerous."
,Q2: According to the text, how does sleep deprivation contribute to weight gain?
A. It slows down the metabolism significantly.
B. It increases ghrelin and decreases leptin. [CORRECT]
C. It prevents the body from absorbing nutrients.
D. It causes fluid retention.
Correct Answer: B
Rationale: [CORRECT] The text explicitly states that deprivation "increases levels of ghrelin... while
decreasing leptin," leading to increased appetite. A/C/D – These mechanisms are not mentioned in the
passage.
Q3: Which of the following is NOT mentioned as a consequence of sleep deprivation in the passage?
A. Diabetes
B. Cardiovascular disease
C. Compromised immune function [CORRECT]
D. Obesity
Correct Answer: C
Rationale: [CORRECT] While a known fact, compromised immune function is not explicitly listed in the
text; the text lists obesity, diabetes, and cardiovascular disease. A/B/D – These are explicitly mentioned.
Q4: The author’s primary purpose in writing this passage is to:
A. Persuade employers to let workers nap.
B. Inform the reader about the health risks associated with insufficient sleep. [CORRECT]
C. Argue that obesity is caused by hormones, not diet.
D. Describe the stages of sleep.
Correct Answer: B
,Rationale: [CORRECT] The tone is factual and educational, outlining the risks. A – No solution for
employers is proposed. C – This misrepresents the text's nuance. D – Sleep stages are mentioned only
briefly in relation to blood pressure.
Q5: Based on the passage, which individual is likely at the highest risk for the heart-related issues
described?
A. Someone who sleeps 8 hours a night.
B. Someone who sleeps 5 hours a night. [CORRECT]
C. Someone who takes naps during the day.
D. Someone who has high leptin levels.
Correct Answer: B
Rationale: [CORRECT] The text states those who sleep "less than six hours a night have a significantly
higher risk." 5 hours fits this criterion. A – This is within the healthy range. D – High leptin signals satiety;
the text associates risk with low leptin.
Passage 2: Scientific (The Immune System)
The human immune system is a complex network of cells, tissues, and organs that work together to
defend the body against attacks by "foreign" invaders. These invaders are primarily microbes—tiny
organisms such as bacteria, parasites, and fungi. The key to a healthy immune system is its ability to
distinguish between the body’s own cells (self) and foreign cells (non-self). When the immune system
mistakenly targets the body's own cells, it results in an autoimmune disease, such as rheumatoid
arthritis. The system comprises two main subsystems: innate immunity, which provides a rapid, non-
specific response, and adaptive immunity, which provides a specific response involving memory cells
that remember past invaders.
Q6: What distinguishes adaptive immunity from innate immunity?
A. Adaptive immunity provides a rapid response; innate is slower.
B. Adaptive immunity involves memory cells and is specific; innate is non-specific. [CORRECT]
C. Innate immunity targets bacteria; adaptive targets viruses.
D. Innate immunity is found in humans; adaptive is found in animals.
, Correct Answer: B
Rationale: [CORRECT] The passage explicitly contrasts the two: innate is "rapid, non-specific," while
adaptive is "specific" and involves "memory cells." A – The speed relationship is reversed; innate is the
rapid one. C – Both target microbes generally. D – Incorrect distinction.
Q7: What happens when the immune system fails to distinguish between "self" and "non-self"?
A. The body becomes more susceptible to infection.
B. An autoimmune disease may develop. [CORRECT]
C. The innate immune system shuts down.
D. The body develops a rapid, non-specific response.
Correct Answer: B
Rationale: [CORRECT] The text defines autoimmune disease as the result of the immune system
mistakenly targeting the body's own cells. A – This describes a weak immune system, not a confused
one. C – This is not stated.
Q8: Which of the following is an example of an autoimmune disease mentioned in the text?
A. Diabetes
B. Rheumatoid arthritis [CORRECT]
C. Influenza
D. Bacterial infection
Correct Answer: B
Rationale: [CORRECT] The text specifically lists rheumatoid arthritis as an example. C/D – These are
invaders/infections, not autoimmune conditions.
Q9: The word "invaders" in the second sentence refers to:
A. The immune system cells.
B. Microbes such as bacteria, parasites, and fungi. [CORRECT]