PHARMACOLOGY TEST BANK
2026||For Nursing & Medical
Students--questions and answers
with rationales/graded A+/2026
update/100% correct /instant
download
Verified Questions with Rationales*
SECTION 1: GENERAL PHARMACOLOGY PRINCIPLES
(50 Questions)
1. A drug with a half-life of 4 hours is administered intravenously.
Approximately how long will it take to reach steady state?
A) 8 hours
B) 12 hour
C) 20 hours
D) 24 hours
Correct Answer: C) 20 hours
*Rationale: Steady state is achieved after 4–5 half-lives (4 × 5 = 20 hours).*
2. Which phase of drug metabolism primarily involves conjugation reactions?
A) Phase I
B) Phase II
C) Absorption phase
D) Distribution phase
, Correct Answer: B) Phase II
Rationale: Phase II reactions (glucuronidation, sulfation, acetylation) increase
water solubility for excretion.
3. A patient with liver cirrhosis is prescribed a drug with high first-pass
metabolism. The nurse expects:
A) Decreased bioavailability
B) Increased bioavailability
C) No change in bioavailability
D) Faster renal excretion
Correct Answer: B) Increased bioavailability
Rationale: Impaired liver function reduces first-pass metabolism, increasing oral
drug bioavailability.
4. The therapeutic index (TI) of a drug is 2.5. This indicates:
A) Wide safety margin
B) Narrow safety margin
C) Drug is 100% bioavailable
D) Drug is renally cleared
Correct Answer: B) Narrow safety margin
*Rationale: TI = TD50/ED50. A low TI (<3) means small difference between
effective and toxic doses.*
5. Which receptor type is directly linked to ion channels?
A) G-protein coupled receptors
B) Tyrosine kinase receptors
C) Ligand-gated ion channels
D) Intracellular receptors
Correct Answer: C) Ligand-gated ion channels
Rationale: These receptors (e.g., nicotinic, GABA-A) open ion channels directly
upon agonist binding.
(Questions 6–50 follow same format; samples shown for brevity. Full 50 available
on request.)
SECTION 2: AUTONOMIC NERVOUS SYSTEM DRUGS
2026||For Nursing & Medical
Students--questions and answers
with rationales/graded A+/2026
update/100% correct /instant
download
Verified Questions with Rationales*
SECTION 1: GENERAL PHARMACOLOGY PRINCIPLES
(50 Questions)
1. A drug with a half-life of 4 hours is administered intravenously.
Approximately how long will it take to reach steady state?
A) 8 hours
B) 12 hour
C) 20 hours
D) 24 hours
Correct Answer: C) 20 hours
*Rationale: Steady state is achieved after 4–5 half-lives (4 × 5 = 20 hours).*
2. Which phase of drug metabolism primarily involves conjugation reactions?
A) Phase I
B) Phase II
C) Absorption phase
D) Distribution phase
, Correct Answer: B) Phase II
Rationale: Phase II reactions (glucuronidation, sulfation, acetylation) increase
water solubility for excretion.
3. A patient with liver cirrhosis is prescribed a drug with high first-pass
metabolism. The nurse expects:
A) Decreased bioavailability
B) Increased bioavailability
C) No change in bioavailability
D) Faster renal excretion
Correct Answer: B) Increased bioavailability
Rationale: Impaired liver function reduces first-pass metabolism, increasing oral
drug bioavailability.
4. The therapeutic index (TI) of a drug is 2.5. This indicates:
A) Wide safety margin
B) Narrow safety margin
C) Drug is 100% bioavailable
D) Drug is renally cleared
Correct Answer: B) Narrow safety margin
*Rationale: TI = TD50/ED50. A low TI (<3) means small difference between
effective and toxic doses.*
5. Which receptor type is directly linked to ion channels?
A) G-protein coupled receptors
B) Tyrosine kinase receptors
C) Ligand-gated ion channels
D) Intracellular receptors
Correct Answer: C) Ligand-gated ion channels
Rationale: These receptors (e.g., nicotinic, GABA-A) open ion channels directly
upon agonist binding.
(Questions 6–50 follow same format; samples shown for brevity. Full 50 available
on request.)
SECTION 2: AUTONOMIC NERVOUS SYSTEM DRUGS
