CIH Toxicology (15-35 questions & answers)Updated 2026

CIH Toxicology (15-35
questions &
answers)Updated 2026
EpoxiesBcanBcauseB-BAnswerBHypersensitivityBpneumonitis



FlourBDustB-BAnswerBAsthmagen,

sensitization,

allergicBrhinitis



FEV1B-BAnswerBAsbestosBlungBfunctionBtest



AnthraceneB-BAnswerB*Photosensitization*Birritation,

componentBofBcoalBtar,BnotBcarcinogen,

*Route*:BInhalation,BSkin,

*Industry*:BCoalBminersBandBAsphalt,

ItsBaBPAHB(3Bring)



AtaxiaB-BAnswerBLossBofBfullBcontrolBofBbodyBmovements,

[Organophosphates]



DoseBResponseBCurve:BSteepBvs.BGradualBCurveB-BAnswerBSteepBSlopeB-
BhigherBriskBasBdoseBincreases,BallBsubjectsBreactBsimiliarly

ShallowBCurveB-BincreaseBinBdoseBhasBminimalBeffect,BvariableBresponse



2BGeneralBHydrocarbon/SolventBRulesB-
BAnswerBIncreaseBinBcarbonBChainB=BIncreaseBinBCNSBeffect,

HalogensBincreaseBCNSBeffect

,CarbonBTetrachlorideB-BAnswerB*FattyBLiver*

AcuteB-BCNS,Bnarcosis,Bdizziness,B*OliguriaB(decreaseBurine)*,

ChronicB-B*liverBandBkidney*Bdamage,

ExposureBRouteB-BInhalation,Bingestion,Bskin,

PossibleBCarcinogen



RadiumB-
BAnswerBAnemia,BCataracts,BFracturedBteeth,BCancer/death,BRadiumBjawB(necrosisBofB
jawBbone),

*SequesteredBinBbones*



Degreaser'sBFlushB-BAnswerBChlorinatedBaliphaticBandBalcohol,

B-BskinBwelts/reactions



3BExamplesBforBInhibitionBofBOxygenBTransferB-BAnswerBCO,BH2S,BHCN



BlocksBHemoglobinBOxygenBTransportB-BAnswerBCarbonBMonoxide,

bindsBwithBhemoglobinBatBsameBsiteBofBoxygenBandBbindsBmoreBreadilyBthanBoxygen



MetabolismB-BAnswerBBIOTRANSFORMATION

MakesBchemicalsBmoreBwaterBsolubleBforBexcretion



CYPBP450B-BAnswerBLiverB*enzyme*BthatBdetoxifiesBsubstances,

MakesBthemBeasierBtoBbeBexcreted.



ToxicokineticsB-BAnswerBMovementBandBdistributionBofBtoxicantsBinBtheBbody,

(whatBhappensBwhenBitBentersBtheBbody?)

, Zero-OrderBvsBFirst-OrderBKineticsB-BAnswerB*Zero-Order*B-
BMetabolismBconstant;BdetoxBrateBisBunaffectedBbyBexposureBrate.

*First-Order*B-BMetabolismBincreasesBwithBlevelBofBexposure



ToxicokinteticBModelB-BAnswerBExposureBlevelBorder:B

PassiveBelimination,

DetoxificationB(bioactivation)B,

SignificantBburden



3BToxicokineticBRulesB-
BAnswerB1)BWaterBsolubleBgoBdirectlyBfromBsmallBintestineBtoBliverBviaBblood.

2)BNon-solubleBusuallyBlessBtoxic.

3)BChemicalsBtendBtoBbeBmostBtoxicBthruBtheBhighestBentryBexposureBrouteB(usuallyB
lungs)



CommonBContactBDermatitisBOccupationsB-BAnswerBMagazineBprinters,

AgricultureB(pesticides),

Artists,

Auto/aircraftBmanufacturers,

MechanicsB(solvents)



SkinBPhotosensitizationB-BAnswerBTarBPitch,

Anthracene,

St.BJohnsBWart,

HorseBBrush,

Tetracycline,



UrticariaB-BAnswerB*SkinBDisorder*B-

Smooth,BelecatedBpatchesBthatBareBredderBorBpalerBthanBsurroundingBskin