University of St. Augustine for Health Sciences NUR 7560
Pathophysiology Exam 2 Review
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Terms in this set (126) Hide definitions
Where does red blood cell (RBC) In the bone marrow.
production occur?
What stimulates the release of Hypoxia.
erythropoietin (EPO)?
What is the sequence of RBC Hematopoietic stem cell → Myeloid progenitor →
development starting from Proerythroblast → Reticulocyte → Mature
hematopoietic stem cells? erythrocyte.
What are the requirements for Iron for hemoglobin synthesis, Vitamin B12 and
erythropoiesis? Folate for DNA synthesis, and EPO for proliferation
signal.
What does a high reticulocyte count Hemolysis or blood loss.
indicate?
What does a low reticulocyte count Bone marrow suppression or deficiency.
indicate?
, What is the classification of anemia <80 = microcytic, 80-100 = normocytic, >100 =
based on MCV? macrocytic.
What are common causes of Iron deficiency, Thalassemia, Anemia of chronic
microcytic anemia? disease (late).
What are common causes of Vitamin B12 deficiency, Folate deficiency, Alcohol
macrocytic anemia? use, Liver disease.
What is Polycythemia Vera? A myeloproliferative neoplasm caused by JAK2
mutation leading to autonomous RBC production.
What are the symptoms of Headache, dizziness, pruritus (especially after
Polycythemia Vera? warm showers), splenomegaly.
What is the role of Vitamin B12 in the DNA synthesis and myelin formation.
body?
What are the neurologic signs of Paresthesia, loss of vibration sense, ataxia.
Vitamin B12 deficiency?
What is the mechanism of Anemia of Inflammation leads to increased IL-6, which
Chronic Disease (ACD)? increases Hepcidin, blocking iron release from
macrophages.
What are Reed-Sternberg cells? Large, bilobed 'owl-eye' cells seen in Hodgkin
lymphoma, which are malignant B cells.
What causes Sickle Cell Crisis? A mutation in the beta-globin gene leading to HbS
polymerization under hypoxia.
What are the complications of Sickle Stroke, organ infarction, infection (functional
Cell Crisis? asplenia).
Pathophysiology Exam 2 Review
(1 review)
Save
Terms in this set (126) Hide definitions
Where does red blood cell (RBC) In the bone marrow.
production occur?
What stimulates the release of Hypoxia.
erythropoietin (EPO)?
What is the sequence of RBC Hematopoietic stem cell → Myeloid progenitor →
development starting from Proerythroblast → Reticulocyte → Mature
hematopoietic stem cells? erythrocyte.
What are the requirements for Iron for hemoglobin synthesis, Vitamin B12 and
erythropoiesis? Folate for DNA synthesis, and EPO for proliferation
signal.
What does a high reticulocyte count Hemolysis or blood loss.
indicate?
What does a low reticulocyte count Bone marrow suppression or deficiency.
indicate?
, What is the classification of anemia <80 = microcytic, 80-100 = normocytic, >100 =
based on MCV? macrocytic.
What are common causes of Iron deficiency, Thalassemia, Anemia of chronic
microcytic anemia? disease (late).
What are common causes of Vitamin B12 deficiency, Folate deficiency, Alcohol
macrocytic anemia? use, Liver disease.
What is Polycythemia Vera? A myeloproliferative neoplasm caused by JAK2
mutation leading to autonomous RBC production.
What are the symptoms of Headache, dizziness, pruritus (especially after
Polycythemia Vera? warm showers), splenomegaly.
What is the role of Vitamin B12 in the DNA synthesis and myelin formation.
body?
What are the neurologic signs of Paresthesia, loss of vibration sense, ataxia.
Vitamin B12 deficiency?
What is the mechanism of Anemia of Inflammation leads to increased IL-6, which
Chronic Disease (ACD)? increases Hepcidin, blocking iron release from
macrophages.
What are Reed-Sternberg cells? Large, bilobed 'owl-eye' cells seen in Hodgkin
lymphoma, which are malignant B cells.
What causes Sickle Cell Crisis? A mutation in the beta-globin gene leading to HbS
polymerization under hypoxia.
What are the complications of Sickle Stroke, organ infarction, infection (functional
Cell Crisis? asplenia).
