Review
Cushing Syndrome - correct answer ✔✔Pathophysiology/Etiology:
-Excess corticosteroids especially glucocorticoids
-Most common cause is corticosteroid (prednisone) medication therapy
Other causes:
-Pituitary, adrenal, lung, pancreatic cancers
-Most common in women 20-40 YOA
Cushing Syndrome - correct answer ✔✔Clinical Manifestations:
-Weight gain
-Abnormal adipose tissue deposits with peripheral muscle wasting
-Skin and hair changes
-Risk of infection and slow wound healing
Cushing Syndrome - correct answer ✔✔Diagnostic Studies:
-Testing for increased plasma cortisol levels
-Late night salivary cortisol level
-24-hour urine cortisol
-Plasma cortisol level after dexamethasone administration
-Radiological studies of pituitary and adrenal glands
-Adherence to the timing and procedures for sample collection ensures accurate results related
to ___ diagnosis
Cushing Syndrome - correct answer ✔✔Interprofessional Care
-Goal of care is to normalize adrenal gland hormone secretion
, -Treatment plan based on causation
-Pituitary tumor surgery or medication suppression
-Adrenalectomy
-Control of hyperglycemia and other manifestations
-Changing corticosteroid (prednisone) dosage and/or schedule
-Decrease daily dose or change to every-other-day
Cushing Syndrome - correct answer ✔✔Goals of Care:
-Relief of symptoms, Avoidance of serious complications,
-Regain/maintain positive self-image, Facilitate adherence to treatment plan
-Assessment & planning for known & potential effects of disease including hyperglycemia,
immunosuppression, coping problems
-Perioperative care as appropriate
Cushing Syndrome - correct answer ✔✔Discharge teaching:
-How to self-assess for therapeutic effects & adverse outcomes of treatment interventions;
when/how to contact provider
-Avoid physiological and emotional stressors
-Medical alert jewelry or card describing ongoing problems or medications
Addison Disease - correct answer ✔✔-Adrenocortical Insufficiency
-Most common cause is an autoimmune destruction of adrenal cortex
-Results in deficiency of all 3 types of adrenal corticosteroids
-Most likely to be diagnosed in adults, independent of gender, under 60
Addison Disease
Addisonian - correct answer ✔✔Clinical Manifestations