MURPHY BIOCHEM RUTGERS EXAM 2
Questions and Answers
1. Acetyl CoA that is consumed by the CAC is produced from
which of the following biochemical pathways?
a. glycolysis
b. fatty acid oxidation
c. purine catabolism
d. urea cycle
e. both A and B are correct
Answer both A and B are correct
2. Which of the following is the strongest reducing agent?
a. FADH2 (+ 0.22 V)
b. H2 (+ 0.424 V)
c. cytochrome a * Fe 2+ (-0.29 V)
d. lactate (+0.19 V)
e. H2O (-0.82 V)
Answer H2
3. Place the following reaction intermediates of the CAC in
chronological order
,i. malate
ii. fumarate
iii. succinyl CoA
iv. citrate
v. a-ketoglutarate
Answer iv, v, iii, ii, i
4. Oxalosuccinate is a transient intermediate formed during which of
the follow- ing reactions?
Answer isocitrate to a-ketoglutarate
5. FADH2 is a product of which of the following reactions?
Answer succinate to fumarate
6. NADH is produced in which of the following reactions?
Answer a-ketoglutarate to succinyl CoA
7. Which of the following reactions can be described as anaplerotic?
Answer pyruvate + co2 to oxaloacetate
8. The
enzymes that are unique to the glyoxylate cycle include
Answer isoci- trate lyase
,9. The regulated enzyme of
the CAC include
Answer a-ketoglutarate dehydrogenase
10. The enzymes involved in citrate metabolism include all of the
following except
Answer malate synthase
11. Redox potential is best defined as
Answer the tendency of a species to gain or lose electrons
12. In order to determine the standard voltage of a reaction
Answer the standard cells must be written as they occur in the reaction and the
voltages are added
13. Which of the following reactions is an oxidation reaction?
a. NaOH + HCl -> NaCl + H2O
b. CH3COOH -> CH3COO- + H+
c. CH3CHO -> CH3CH2OH
d. CH3CH2OH -> CH3CHO
e. CH2=CH2 + H2O -> CH3CH2OH
Answer CH3CH2OH -> CH3CHO
, 14. Which of the following reactions has an oxidized product?
a. carboxylic acid -> aldehyde
b. R-SH + R-SH -> R-S-S-R
c. alcohol -> ketone
d. glutamate -> a-ketoglutarate
e. none of the above
Answer none of the above
15. In any redox reaction, an electron donor is
Answer the reducing agent
16. In an redox reaction, an electron acceptor is
Answer converted to an electron donor with the gain of one or more electrons
17. Each turn of the CAC produces how many moles of CO2?
Answer 2
18. Which of the following reacts with the acetyl-CoA to form
citrate?
Answer oxaloacetate
19. The redox reaction in which succinate is converted to
fumarate uses FAD rather than NAD+ because?
Questions and Answers
1. Acetyl CoA that is consumed by the CAC is produced from
which of the following biochemical pathways?
a. glycolysis
b. fatty acid oxidation
c. purine catabolism
d. urea cycle
e. both A and B are correct
Answer both A and B are correct
2. Which of the following is the strongest reducing agent?
a. FADH2 (+ 0.22 V)
b. H2 (+ 0.424 V)
c. cytochrome a * Fe 2+ (-0.29 V)
d. lactate (+0.19 V)
e. H2O (-0.82 V)
Answer H2
3. Place the following reaction intermediates of the CAC in
chronological order
,i. malate
ii. fumarate
iii. succinyl CoA
iv. citrate
v. a-ketoglutarate
Answer iv, v, iii, ii, i
4. Oxalosuccinate is a transient intermediate formed during which of
the follow- ing reactions?
Answer isocitrate to a-ketoglutarate
5. FADH2 is a product of which of the following reactions?
Answer succinate to fumarate
6. NADH is produced in which of the following reactions?
Answer a-ketoglutarate to succinyl CoA
7. Which of the following reactions can be described as anaplerotic?
Answer pyruvate + co2 to oxaloacetate
8. The
enzymes that are unique to the glyoxylate cycle include
Answer isoci- trate lyase
,9. The regulated enzyme of
the CAC include
Answer a-ketoglutarate dehydrogenase
10. The enzymes involved in citrate metabolism include all of the
following except
Answer malate synthase
11. Redox potential is best defined as
Answer the tendency of a species to gain or lose electrons
12. In order to determine the standard voltage of a reaction
Answer the standard cells must be written as they occur in the reaction and the
voltages are added
13. Which of the following reactions is an oxidation reaction?
a. NaOH + HCl -> NaCl + H2O
b. CH3COOH -> CH3COO- + H+
c. CH3CHO -> CH3CH2OH
d. CH3CH2OH -> CH3CHO
e. CH2=CH2 + H2O -> CH3CH2OH
Answer CH3CH2OH -> CH3CHO
, 14. Which of the following reactions has an oxidized product?
a. carboxylic acid -> aldehyde
b. R-SH + R-SH -> R-S-S-R
c. alcohol -> ketone
d. glutamate -> a-ketoglutarate
e. none of the above
Answer none of the above
15. In any redox reaction, an electron donor is
Answer the reducing agent
16. In an redox reaction, an electron acceptor is
Answer converted to an electron donor with the gain of one or more electrons
17. Each turn of the CAC produces how many moles of CO2?
Answer 2
18. Which of the following reacts with the acetyl-CoA to form
citrate?
Answer oxaloacetate
19. The redox reaction in which succinate is converted to
fumarate uses FAD rather than NAD+ because?
