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Pharmacology HESI Exam: Comprehensive Review & Practice Questions (2026/2027 Verified Solutions)

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Dominate your Pharmacology HESI Exam with this definitive study resource updated for the 2026/2027 cycle. This guide features 100% verified questions and answers covering high-yield nursing pharmacology topics. Master critical concepts such as insulin management (NPH vs. Regular), antibiotic protocols (Rifampin, Tetracycline, Vancomycin), and respiratory therapies for asthma and COPD. Gain deep insights into GI medications (PPIs, H2 Blockers), anaphylaxis first-line treatments, and essential patient teaching for medication safety and side effect monitoring. Perfect for nursing students seeking a straight-to-the-point review for a guaranteed pass.

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PHARMACOLOGY HESI EXAM WITH 100%
CORRECT ANSWERS 2026/2027

Which nursing action is the priority when administering chelation therapy for a toddler-
age client?
1 Assessing vital signs
2 Monitoring urine output
3 Conducting a behavioral assessment
4 Providing education to reduce lead exposure correct answers 2

A 67-year-old client has tested positive for influenza A. The client also has asthma.
Which drug would the nurse recommend be avoided in this client?
1 Ribavirin
2 Zanamivir
3 Oseltamivir
4 Amantadine correct answers 2

Which first line medication would the nurse state is used to treat anaphylactic reactions?
1 Epinephrine
2 Norepinephrine
3 Dexamethasone
4 Diphenhydramine correct answers 1

A mother complains that her child's teeth have become yellow in color. With prolonged
use, which medication may be responsible for the child's condition?
1 Tetracycline
2 Promethazine
3 Chloramphenicol
4 Fluoroquinolones correct answers 1

What are the desired outcomes that the nurse expects when administering a
nonsteroidal antiinflammatory drug (NSAID)? Select all that apply
1 Diuresis
2 Pain relief
3 Antipyresis
4 Bronchodilation
5 Anticoagulation
6 Reduced inflammation correct answers 2,3,6

,A client with tuberculosis is started on a chemotherapy protocol that includes rifampin.
The nurse evaluates that the teaching about rifampin is effective when the client makes
which statement?
1 "I need to drink a lot of fluid while I take this medication."
2 "I can expect my urine to turn orange from this medication."
3 "I should have my hearing tested while I take this medication."
4 "I might get a skin rash because it is an expected side effect of this medication.
correct answers 2

Which statement regarding treatment with interferon indicates that the client
understands the nurse's teaching?
1 "I will drink 2 to 3 quarts (2 to 3 liters) of fluid a day."
2 "Any reconstituted solution must be discarded in 1 week."
3 "I can continue driving my car as long as I have the stamina."
4 "While taking this medicine I should be able to continue my usual activity." correct
answers 1

A nurse administers the drug desmopressin acetate (DDAVP) to a client with diabetes
insipidus. What should the nurse monitor to evaluate the effectiveness of the drug? 1
Arterial blood pH
2 Intake and output
3 Fasting serum glucose
4 Pulse and respiratory rates correct answers 2

A client will be taking nitrofurantoin 50 mg orally every evening at home to manage
recurrent urinary tract infections. What instructions should the nurse give to the client?
1 Increase the intake of fluids.
2 Strain the urine for crystals and stones.
3 Stop the drug if urinary output increases.
4 Maintain the exact time schedule for taking the drug correct answers 1

A client admitted to the hospital with a diagnosis of chronic obstructive pulmonary
disease has received a prescription for a medication that is delivered via a nebulizer.
When teaching about use of the nebulizer, the nurse should teach the client to do what?
1 Hold the breath while spraying the medication into the mouth.
2 Position the lips loosely around the mouthpiece and take rapid, shallow breaths. 3
Seal the lips around the mouthpiece and breathe in and out, taking slow, deep
breaths.
4 Inhale the medication from the nebulizer, remove the mouthpiece from the mouth, and
then exhale. correct answers 3

A client is diagnosed with pulmonary tuberculosis, and the healthcare provider
prescribes a combination of rifampin and isoniazid. The nurse evaluates that the

, teaching regarding the drug is effective when the client reports which action as most
important?
1 "Report any changes in vision."
2 "Take the medicine with my meals."
3 "Call my doctor if my urine or tears turn red-orange."
4 "Continue taking the medicine even after I feel better. correct answers 4

A nurse administers beclomethasone by inhalation to a client with asthma, and the client
asks why this medication is necessary. What should the nurse explain is the purpose of
this pharmacologic therapy?
1 Promotes comfort
2 Decreases inflammation
3 Stimulates smooth muscle relaxation
4 Reduces bacteria in the respiratory tract correct answers 2

A nurse is caring for a female client who is receiving rifampin for tuberculosis. Which
statements indicate that the client understands the teaching about rifampin? Select all
that apply
1 "This drug may be hard on my liver so I must avoid alcoholic drinks while taking it."
2 "This drug may reduce the effectiveness of the oral contraceptive I am taking."
3 "I cannot take an antacid within 2 hours before taking my medicine."
4 "My healthcare provider must be called immediately if my eyes and skin become
yellow. correct answers 1,2,4

The nurse provides discharge teaching to a client with tuberculosis. Which treatment
measure does the nurse reinforce as the highest priority?
1 Getting sufficient rest
2 Getting plenty of fresh air
3 Changing the current lifestyle
4 Consistently taking prescribed medication correct answers 4

A client is diagnosed with tuberculosis associated with human immunodeficiency virus
infection. What crucial laboratory test results should the nurse review before
antitubercular pharmacotherapy is started?
1 Liver function studies
2 Pulmonary function studies
3 Electrocardiogram and echocardiogram
4 White blood cell (WBC) count and sedimentation rate correct answers 1

Pyridoxine (vitamin B6) and isoniazid (INH) are prescribed as part of the chemotherapy
protocol for a client with tuberculosis. Which response indicates to the nurse that
vitamin B6 is effective?
1 Weight gain

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