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A patient's nutritional intake and laboratory results reflect hypoalbuminemia. This is
critical to prescribing because: -ANSWERS-Distribution of drugs to target tissue may be
affected.
Drugs that have a significant first-pass effect: -ANSWERS-Are rapidly metabolized by
the liver and may have little if any desired action
The route of excretion of a volatile drug will likely be the: -ANSWERS-Lungs
Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose
of both of these types of reactions is to: -ANSWERS-Change drug molecules to a form
that an excretory organ can excrete
Once they have been metabolized by the liver, the metabolites may be: -ANSWERS-
More active than the parent drug
Less active than the parent drug
Totally "deactivated" so they are excreted without any effect
All drugs continue to act in the body until they are changed or excreted. The ability of
the body to excrete drugs via the renal system would be increased by: -ANSWERS-
Unbinding a nonvolatile drug from plasma proteins
Steady state is: -ANSWERS-When the amount of drug in the body remains constant
, Two different pain medications are given together for pain relief. The drug—drug
interaction is: -ANSWERS-Additive
Actions taken to reduce drug—drug interaction problems include all of the following
EXCEPT:
1. Reducing the dosage of one of the drugs
2. Scheduling their administration at different times
3. Prescribing a third drug to counteract the adverse reaction of the combination
4. Reducing the dosage of both drugs -ANSWERS-3. Prescribing a third drug to
counteract the adverse reaction of the combination
Phase I oxidative-reductive processes of drug metabolism require certain nutritional
elements. Which of the following would reduce or inhibit this process?
1. Protein malnutrition
2. Iron-deficiency anemia
3. Both 1 and 2
4. Neither 1 nor 2 -ANSWERS-4. Neither 1 nor 2
The time required for the amount of drug in the body to decrease by 50% is called: -
ANSWERS-Half-life
An agonist activates a receptor and stimulates a response. When given frequently over
time, the body may: -ANSWERS-Downregulate the numbers of that specific receptor
Drug antagonism is best defined as an effect of a drug that: -ANSWERS-Is modified by
the concurrent administration of another drug
Instructions to a client regarding self-administration of oral enteric-coated tablets should
include which of the following statements? -ANSWERS-"To achieve best effect, take the
tablet with at least 8 ounces of fluid."